ID A1CH65_ASPCL Unreviewed; 534 AA.
AC A1CH65;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|RuleBase:RU369096};
GN ORFNames=ACLA_046860 {ECO:0000313|EMBL:EAW10220.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW10220.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW10220.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Involved in spliceosome maturation and the first step of pre-
CC mRNA splicing. {ECO:0000256|RuleBase:RU369096}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU369096}.
CC -!- SIMILARITY: Belongs to the SPP2 family. {ECO:0000256|ARBA:ARBA00008576,
CC ECO:0000256|RuleBase:RU369096}.
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DR EMBL; DS027054; EAW10220.1; -; Genomic_DNA.
DR RefSeq; XP_001271646.1; XM_001271645.1.
DR AlphaFoldDB; A1CH65; -.
DR STRING; 344612.A1CH65; -.
DR EnsemblFungi; EAW10220; EAW10220; ACLA_046860.
DR GeneID; 4704432; -.
DR KEGG; act:ACLA_046860; -.
DR VEuPathDB; FungiDB:ACLA_046860; -.
DR eggNOG; ENOG502RZY8; Eukaryota.
DR HOGENOM; CLU_033338_0_1_1; -.
DR OMA; AWGKSAM; -.
DR OrthoDB; 55448at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR045166; Spp2-like.
DR InterPro; IPR026822; Spp2/MOS2_G-patch.
DR PANTHER; PTHR15818; G PATCH AND KOW-CONTAINING; 1.
DR PANTHER; PTHR15818:SF2; G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN; 1.
DR Pfam; PF12656; G-patch_2; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|RuleBase:RU369096};
KW mRNA splicing {ECO:0000256|RuleBase:RU369096};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU369096};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Spliceosome {ECO:0000256|RuleBase:RU369096}.
FT DOMAIN 263..288
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 60313 MW; A1C6A1C9C8881355 CRC64;
MSPSQSLDDG KPSSKPFSLS LSGSSTPNGQ SKKTAFNLQP SRGPPPPSRS LARRPHHLHD
DESDEEERPP AFETVSGFDT LTGTALAADG RAVDNMKREL VIPVTSKNNW RDRPGTNTRP
RGKNLLPKEV QAMQEAEKRG QTVGENHETD RPNMSYGLSF AKPAAVVEEG KAGEDQTMKD
AGPLVPPVTD ERKPMTQDEI ALQALIRESN GDTERRSDLV IESAPGQAGT ESGGRYDETG
SFRADVASRP ESASLDQYNA IPVEEFGAAL LRGMGWKEGQ SIGRGKYGTS ATDDRSQKAR
IPERRPGFLG IGAKDASGGK GAEAELGAWG KAAMRKGARK AGENQGGEGN TEGVYMPVLM
RNKQTGEYIT EEELAALKKE ARTKKDDDDW RERRDRNLEK SGRDKDRDRE HRRRDYDDVD
SSDRYGRRRT GASRRERSSS TSDRHSRRRK YEDEDGSARD DLYYRERDRD RDRRDRDWEK
ERDRDRSRDR SSKHRDDDRY NSRHSSSHTS SRHGRDRDRE SDRDSHRRRR RDDR
//
