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Database: UniProt
Entry: A1CH78
LinkDB: A1CH78
Original site: A1CH78 
ID   DED1_ASPCL              Reviewed;         681 AA.
AC   A1CH78;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   31-JUL-2019, entry version 65.
DE   RecName: Full=ATP-dependent RNA helicase ded1;
DE            EC=3.6.4.13;
GN   Name=ded1; ORFNames=ACLA_046980;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC
OS   3887 / NRRL 1).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in translation
CC       initiation. Remodels RNA in response to ADP and ATP concentrations
CC       by facilitating disruption, but also formation of RNA duplexes (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX3/DED1
CC       subfamily. {ECO:0000305}.
DR   EMBL; DS027054; EAW10233.1; -; Genomic_DNA.
DR   RefSeq; XP_001271659.1; XM_001271658.1.
DR   SMR; A1CH78; -.
DR   STRING; 5057.CADACLAP00004486; -.
DR   PRIDE; A1CH78; -.
DR   EnsemblFungi; EAW10233; EAW10233; ACLA_046980.
DR   GeneID; 4704355; -.
DR   KEGG; act:ACLA_046980; -.
DR   EuPathDB; FungiDB:ACLA_046980; -.
DR   HOGENOM; HOG000268804; -.
DR   KO; K11594; -.
DR   OMA; CYRSWVR; -.
DR   OrthoDB; 595675at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase;
KW   Initiation factor; Nucleotide-binding; Protein biosynthesis;
KW   Reference proteome; RNA-binding.
FT   CHAIN         1    681       ATP-dependent RNA helicase ded1.
FT                                /FTId=PRO_0000281686.
FT   DOMAIN      220    413       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      424    585       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     233    240       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       189    217       Q motif.
FT   MOTIF       357    360       DEAD box.
FT   COMPBIAS    588    676       Gly-rich.
SQ   SEQUENCE   681 AA;  72165 MW;  0605F9D822DA46FD CRC64;
     MADGLNMGNL SLNDSQHAPA GPGNTGRAAY IPPHLRGRAG GANVDAAAAA APPPGPAAWN
     GPRQGAPPRG GNWANANASD FSPRAPSGPN GNNSWTPSEG QRRPFDPHAY GHPGHGGSYG
     GSQGASTRGS GDGQWRDGKH IPGPANARLE RELFGVPNDP TKQSTGINFA NYDDIPVEAS
     GQDVPEPVNA FTNPPLDDHL ISNIKLARYQ TPTPVQKYSI PIVMNGRDLM ACAQTGSGKT
     GGFLFPILSQ AFQKGPSAVP AQASGQMSYG RQRKAYPTSL ILAPTRELVS QIFDEARKFA
     YRSWVRPCVV YGGADIGSQL RQIERGCDLL VATPGRLVDL IERGRISLVN INYLVLDEAD
     RMLDMGFEPQ IRRIVEGEDM PSVNERQTLM FSATFPRDIQ MLARDFLKDY VFLSVGRVGS
     TSENITQKVE YVEDVDKRSV LLDILHTHGT SGLTLIFVET KRMADALSDF LINQRFPATA
     IHGDRTQRER ERALEMFRSA RCPILVATAV AARGLDIPNV THVINYDLPT DIDDYVHRIG
     RTGRAGNTGI ATAFFNRGNR GVVRELIDLL KEAHQEVPSF LESIAREGSG YGGRGGRGGR
     GRGGNANRDV RRMGGAMGGG APSFGGGSYG GPGGSYGGGS YGGGAAAPSY GGGYGGASGG
     GGSYGGSYGN PSGPTGPSSW W
//
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