ID A1CH95_ASPCL Unreviewed; 574 AA.
AC A1CH95;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
GN ORFNames=ACLA_047190 {ECO:0000313|EMBL:EAW10250.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW10250.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW10250.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363039}.
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DR EMBL; DS027054; EAW10250.1; -; Genomic_DNA.
DR RefSeq; XP_001271676.1; XM_001271675.1.
DR AlphaFoldDB; A1CH95; -.
DR STRING; 344612.A1CH95; -.
DR EnsemblFungi; EAW10250; EAW10250; ACLA_047190.
DR GeneID; 4704357; -.
DR KEGG; act:ACLA_047190; -.
DR VEuPathDB; FungiDB:ACLA_047190; -.
DR eggNOG; KOG0436; Eukaryota.
DR HOGENOM; CLU_009710_9_0_1; -.
DR OMA; MDTQAFC; -.
DR OrthoDB; 166496at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07957; Anticodon_Ia_Met; 1.
DR CDD; cd00814; MetRS_core; 1.
DR Gene3D; 2.170.220.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR041872; Anticodon_Met.
DR InterPro; IPR014758; Met-tRNA_synth.
DR InterPro; IPR023457; Met-tRNA_synth_2.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR033911; MetRS_core.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00398; metG; 1.
DR PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR01041; TRNASYNTHMET.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701}.
FT DOMAIN 55..421
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
SQ SEQUENCE 574 AA; 64917 MW; 148512C41A5CAC24 CRC64;
MAPYRGGFRA LSWAGQFLGH KRPAWRCASC RTATGTIPPR RYVTTTSEKV SKKPYYVTTP
IFYVNAAPHV GHFYTMVIAD ILKRWQVLLG NKNAQLLTGT DEHGMKIQQA ALAAGMDTQA
FCDMNCKTFE ALAKAANIDN DHFIRTTDPA HKEAVQYFWE ILNHRGYIYT SKHEGWYSVS
DETFYPPTQV QNSLDPSTGR KRMVSTETGK EVEWSSETNY HFRLSAFQDR LLEFYSSTDF
IAPGNYKTDI VKSVSSGLSD LSISRPVERL TWGIPVPGDE TQTIYVWLDA LVNYLTRAGY
PFVPGQESRL GWPADVHVVG KDIVRFHCVY WPAFLMALDL PLPRRVLVHG HWTMNREKMS
KSTGNVVNPF FAIDRFGVDT MRFFLAYQGG LVGDADYDNS FIIRDYKKML QWGIGNLAHR
TIGCAKGKLR SYIQDAAADK LPPATPADQE HQSLLEHTPG KVAEQMEKLN PRAALQDIMT
IIERTNKYFH AAEPWSNPAE SQRVLYNVAE SLRISGILLQ PFMPSKSNEL LDILRVDSAD
PSKRSFPAAT FGRDPDYGED VKKSVLFPPL IIEE
//
