ID A1CID7_ASPCL Unreviewed; 480 AA.
AC A1CID7;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=RNA methylase family protein {ECO:0000313|EMBL:EAW10642.1};
GN ORFNames=ACLA_051140 {ECO:0000313|EMBL:EAW10642.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW10642.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW10642.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
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DR EMBL; DS027054; EAW10642.1; -; Genomic_DNA.
DR RefSeq; XP_001272068.1; XM_001272067.1.
DR AlphaFoldDB; A1CID7; -.
DR STRING; 344612.A1CID7; -.
DR EnsemblFungi; EAW10642; EAW10642; ACLA_051140.
DR GeneID; 4703729; -.
DR KEGG; act:ACLA_051140; -.
DR VEuPathDB; FungiDB:ACLA_051140; -.
DR eggNOG; KOG2671; Eukaryota.
DR HOGENOM; CLU_029646_3_0_1; -.
DR OMA; QAFNKWS; -.
DR OrthoDB; 5488599at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR GO; GO:0043528; C:tRNA (m2G10) methyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0160102; F:tRNA (guanine(10)-N2)-methyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0030488; P:tRNA methylation; IEA:EnsemblFungi.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EAW10642.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 193..310
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
SQ SEQUENCE 480 AA; 54614 MW; 0D4385B6A60089F6 CRC64;
MEYLIRFAQV HESFRQPEIQ ALAALKGIDL EILSYNEFSP YCLVKLKNEE TARDLISRSI
LAKDIFELWG QGTNYDEVHE EVRRRTQHRW NDYKEVSFRF TIESFAGKRS NEVKRDIIQS
FAYLDFQGPI RMKNPDEDFW VLEEYVSDVA VSKTAPSPGS AQPVEPQHPQ KIYFGRWVAN
SSRDVVNKYD LKKRRYISTT SMDAELSLVT ANMAHAAPGK LFFDPFVGTG SFCVTAAHFG
ALTLGSDIDG RSFRGKEMDK GKPMGVLSNF QQYGTMGKFM DVFTSDLTNT PLRSSQFLDG
IVCDPPYGVR EGLRVLGTRD GRGKEELLIN GVPAHYLPGY IAPKKPYGFE AMLNDILEFA
SRSLVTNGRL AMWMPTSSDE EGELAIPMHP NLEVLSISVQ PFNNWSRRLI TYRRLPEGET
SDVSLGRRKG DAEGVYADDL NAFRRKVHLS LLTDFYGKSM ADSNIVFQEE PKHEDHIRYK
//
