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Database: UniProt
Entry: A1CP46_ASPCL
LinkDB: A1CP46_ASPCL
Original site: A1CP46_ASPCL 
ID   A1CP46_ASPCL            Unreviewed;      1018 AA.
AC   A1CP46;
DT   23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   23-JAN-2007, sequence version 1.
DT   16-JAN-2019, entry version 75.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   ORFNames=ACLA_021260 {ECO:0000313|EMBL:EAW07417.1};
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 /
OS   NCTC 3887 / NRRL 1).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW07417.1, ECO:0000313|Proteomes:UP000006701};
RN   [1] {ECO:0000313|EMBL:EAW07417.1, ECO:0000313|Proteomes:UP000006701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC   {ECO:0000313|Proteomes:UP000006701};
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675,
CC         ECO:0000256|SAAS:SAAS01116863};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; DS027059; EAW07417.1; -; Genomic_DNA.
DR   RefSeq; XP_001268843.1; XM_001268842.1.
DR   ProteinModelPortal; A1CP46; -.
DR   STRING; 5057.CADACLAP00001914; -.
DR   EnsemblFungi; EAW07417; EAW07417; ACLA_021260.
DR   GeneID; 4700672; -.
DR   KEGG; act:ACLA_021260; -.
DR   EuPathDB; FungiDB:ACLA_021260; -.
DR   HOGENOM; HOG000181922; -.
DR   OMA; GGEDYVD; -.
DR   OrthoDB; 179316at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.102.20.10; -; 1.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.390.10; -; 1.
DR   InterPro; IPR018954; Betagal_dom2.
DR   InterPro; IPR037110; Betagal_dom2_sf.
DR   InterPro; IPR025972; BetaGal_dom3.
DR   InterPro; IPR036833; BetaGal_dom3_sf.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF10435; BetaGal_dom2; 1.
DR   Pfam; PF13363; BetaGal_dom3; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 2.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SMART; SM01029; BetaGal_dom2; 1.
DR   SUPFAM; SSF117100; SSF117100; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006701};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20   1018       Beta-galactosidase. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5002633756.
FT   DOMAIN      406    584       BetaGal_dom2. {ECO:0000259|SMART:
FT                                SM01029}.
SQ   SEQUENCE   1018 AA;  111215 MW;  A7BBB182EF6E7519 CRC64;
     MKLLSVCAVA LLATQAASAS IRHKLNGFTL TEHADPAKRE LLQKHVAWDD KSLFINGERI
     MIFSGEFHPF RLPVPSLWID ILQKIKALGF NCVSFYIDWA LLEGKPGEYT AEGNFALEPF
     FDAAKKAGIY LLARPGPYIN AEVSGGGFPG WLQRVNGTLR SADPAFLKAT DNYISNVAKT
     IAKAQITNGG PVILYQPENE YSGACCDQKF PDPDYMQYVI DQARDAGIVV PMISNDAYAG
     GHNAPGTGNG EVDIYGHDSY PEIQACGQKV ACLPISGRIT LRKAPTPRTL SLRWASPDPL
     CCRSLNITQF QAGAFDPWGG PGFAACAALV DHEFERVFYK NDLSFGSAIL NLYMTFGGTN
     WGNLGHPGGY SSYDYGSPLT ESRNITREKY SELKLIGNFL KASPSYLVAT PGSLSTTGYA
     DTAELIVTPL LGNGTGSYFV VRHTDYTSQK STSYKLTLPT SAGKVTIPQL GGTLSLNGRD
     SKVHVADYKV AGTNILYSTA EVFTWKKFAD GKVLVLYGGP GEHHEFAISS TSDVKIVEGS
     KSGIESKNIS GAVVVAWDVS ATRRIVQIDD LKVLLLDRNS AYNYWVPQLD EDGSSTGYST
     EKTTASSIIV KAGYLVRTAY TKGSGLYLTA DFNATTPLEV IGAPETAKHL FINGKKTQVN
     VDKNGFWSTK VEYSPPKIQL PNLKNLDWRY LDTLPEIQSS YDDSAWTAAD LKTTPNTLRP
     LTTPTSLYSS DYGFHAGYLI YRGHFVADGS ETTFDVRTQG GSVFGSSIWL NRTFLGSWTG
     LNADADYNST YKLPKVESGK PYVFTVVVDT MGLDENWVVG TDEMKNPRGI LSYKLSGRDS
     DAITWRLTGN LGGEDYQDKI RGPLNEGGLY AERQGFHQPQ PPSTRWESAS PLDGLTKPGI
     GFYSARFDLD IPRGWDVPLY LNFGNSTTSA AYRVQLYVNG YQYGKLVSNI GPQTSFPVPE
     GILNYRGTNW IALTLWALES AGAKLESFEL ANTTPVLTAL SEVEASKQPK YSPRKGAY
//
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