ID   A1CP98_ASPCL            Unreviewed;       865 AA.
AC   A1CP98;
DT   23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   23-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   RecName: Full=MHD domain-containing protein {ECO:0000259|PROSITE:PS51072};
GN   ORFNames=ACLA_021830 {ECO:0000313|EMBL:EAW07469.1};
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW07469.1, ECO:0000313|Proteomes:UP000006701};
RN   [1] {ECO:0000313|EMBL:EAW07469.1, ECO:0000313|Proteomes:UP000006701}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC   {ECO:0000313|Proteomes:UP000006701};
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
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DR   EMBL; DS027059; EAW07469.1; -; Genomic_DNA.
DR   RefSeq; XP_001268895.1; XM_001268894.1.
DR   AlphaFoldDB; A1CP98; -.
DR   STRING; 344612.A1CP98; -.
DR   EnsemblFungi; EAW07469; EAW07469; ACLA_021830.
DR   GeneID; 4701495; -.
DR   KEGG; act:ACLA_021830; -.
DR   VEuPathDB; FungiDB:ACLA_021830; -.
DR   eggNOG; ENOG502QQAW; Eukaryota.
DR   HOGENOM; CLU_011037_0_0_1; -.
DR   OMA; FQTHEVD; -.
DR   OrthoDB; 2056337at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   CDD; cd09264; AP_Syp1_MHD; 1.
DR   CDD; cd07650; F-BAR_Syp1p_like; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR028565; MHD.
DR   InterPro; IPR018808; Muniscin_C.
DR   InterPro; IPR049609; Syp1-like_MHD.
DR   PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR23065:SF54; SUPPRESSOR OF YEAST PROFILIN DELETION; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF10291; muHD; 1.
DR   SMART; SM00055; FCH; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006701}.
FT   DOMAIN          574..843
FT                   /note="MHD"
FT                   /evidence="ECO:0000259|PROSITE:PS51072"
FT   REGION          240..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          307..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          499..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          818..841
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..342
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        513..563
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   865 AA;  94378 MW;  CC3D6B8FB671A234 CRC64;
     MDLSRQEYPA LLASLQPSQA INVLNDRIRV INKINADIAD WLQERRRVEE AYAQGLRKLA
     HRPQLDNGAA LGIFQLPWQR IINATETVAS SHEIFAQKIE EDVERPLREY SSKNRELSSM
     PGVERDLAAL VKSFDVAQKK VDKARDKGPK GADRLASAIS AAEEVREQWE SRAPFVFEQL
     QAADEGRLNH LRDVLTQLQT HESDHVERSR QAAESCLNVL LNAETADEIK TFAAKVNGGR
     PIAPRRQESM PVSAPPLAPP PRLQDDAASQ RSGSSGAVRP PPVPEPRNTP LGGLKRLGTV
     MGRRKSIVHT GGGAPFSSDK KHRSPFASFK RGDSRDMPIP ESPTEADRPA TALTTQESRG
     ETAHIPNDIH ERELPASPPM SPEPGPQQTP AATNGAPHPE IQNEPALPPI PSANEEPQVD
     SEGFSERPQT IDEITRLQRE AAGLDEQGMN LTIRDQPILE DENQAKQAMD EMASQLRLQA
     QHSGVRRTAS TLRGRRDVRN TVFIPNPPGS SHGPPTLASG SDISAPTSPG LPTRHITSPS
     AATDDHTLSD TTSIRSSHTL HSISGPVAHP DLHQPGLNAS IIETVSAWFT EGAVTKSFVV
     GELALAYNAS TGPSIDHMRV RLDNFQELEK VAANPHFVKE EREQGDENRG EYDVLLANIA
     RPSPTVAFKY QVHIDPLDLS AYCPVIFKPA WNLEEFQASV IIFYSMNPSF ASSVPRQSIT
     LKNLTLTVNL DTSPEDGRQV AHATSAVMYP NAGAAFRRKQ SAVTWKIPEL DVQAGTDGKL
     LVRFATSASW PRKGKVDAKF ELHTADAGSR LGISTVSPSE YASQNDSDPF ADEGAATHAP
     ESQPLAVWKG LPTTRKLVAG KYVSH
//