ID A1CPF6_ASPCL Unreviewed; 1079 AA.
AC A1CPF6;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Regulator of nonsense transcripts, putative {ECO:0000313|EMBL:EAW07527.1};
GN ORFNames=ACLA_022410 {ECO:0000313|EMBL:EAW07527.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW07527.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW07527.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; DS027059; EAW07527.1; -; Genomic_DNA.
DR RefSeq; XP_001268953.1; XM_001268952.1.
DR AlphaFoldDB; A1CPF6; -.
DR STRING; 344612.A1CPF6; -.
DR EnsemblFungi; EAW07527; EAW07527; ACLA_022410.
DR GeneID; 4701772; -.
DR KEGG; act:ACLA_022410; -.
DR VEuPathDB; FungiDB:ACLA_022410; -.
DR eggNOG; KOG1802; Eukaryota.
DR HOGENOM; CLU_001666_4_0_1; -.
DR OMA; VRSNDNQ; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd21407; 1B_UPF1-like; 1.
DR CDD; cd18039; DEXXQc_UPF1; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR CDD; cd21400; ZBD_UPF1-like; 1.
DR Gene3D; 2.40.30.230; -; 1.
DR Gene3D; 6.10.140.1240; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR040812; UPF1_1B_dom.
DR InterPro; IPR018999; UPF1_CH/ZBD.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR Pfam; PF13086; AAA_11; 2.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF18141; UPF1_1B_dom; 1.
DR Pfam; PF09416; UPF1_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51997; UPF1_CH_RICH; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT DOMAIN 65..222
FT /note="Upf1"
FT /evidence="ECO:0000259|PROSITE:PS51997"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..105
FT /note="C3H"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 87..115
FT /note="CC/SHH/C"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 133..163
FT /note="C4"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT REGION 1023..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1079 AA; 118606 MW; 5F247FA53C568AD4 CRC64;
MAAIGDGRTT ADLDETTLNL SGGPRPRRHD DDDEGSDNFG DDDGDSVTSA AVTGHRKNEG
HAEEEKELPP HACAYCGIHN PSSVVKCLAC SKWFCSARGN TSSSHIVNHL VRARHKEVQL
HPGSSLGDTI LECYNCGTKN VFLLGFIPAK SDTVVVLLCR QPCAAMPSSK DMNWDTSRWQ
PLIEDRSFLP WLVAAPSDQE QLRARHLSPQ LIAKLEEMWK ENSQATFADL EKATAVDDEP
APVLLRYDDA FQYQNIFGPL VKIEADYDRK LKESQSQDGL IVRWDLGLNN KHLASFILPK
LELGDVKLAV GDEMRLKYSG ELRPKWEGVG YVIKIPNNQS DEVTIELRAK GDHKSVPTEC
THNFTADYVW KSTSFDRMQL AMKTFAVDEM SVSGYIFHRL LGHEVAAAPM KTQLPKKFSV
PGLPELNGSQ INAVKSVLQR PMSLIQGPPG TGKTVTSATI IYHLAKINGG QVLVCAPSNV
AVDQLCERIH RTGLKTVRVT AKSREDVESP VGFLSLHEQV RLNDSNIELI KLNQLKAELG
ELSSQDEKRL KQLTRSAERE ILNNADVICC TCVGAGDPRL SKLKFRTVLI DESTQSAEPE
CMIPLVLGCK QVVLVGDHQQ LGPVIMNKKA AKAGLNQSLF ERLVILGCSP IRLNVQYRMH
PCLSQFPSNM FYEGSLQNGV SAIDRLRRDV DFPWPVVDSP MMFWSNLGNE EISASGTSYL
NRTEATNVEK IVTRFFKAGV HPQDIGIITP YEGQRSYIVS SMQANGTFKK EHYKEIEVAS
VDAFQGREKD FIILSCVRSN DHQGIGFLSD PRRLNVALTR AKYGLVILGN PKVLSKHPLW
NCLLQHFKEQ HCLVEGPLSN LQESLIQFSR PKQAYRGPQR FQMAYNHASN VTSGMMNGRN
GHRNEFHDSG SVVGYIPDDV SSVHSSALGG VSVPSGYPPM FQNFTDSWPA LSGARRANGA
RGKGAPSVAG ESVAATESDV TSSVIDGRSV DQGGVSLAGL SIHDMSRQPS LSQSDRLKRY
VESGGREPYR AGVPDNSSIF GGSSASIRVT RGVPGLIHDD DDTRSVSTAF ASQVGGNYD
//
