ID A1CUR1_ASPCL Unreviewed; 3143 AA.
AC A1CUR1;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=ACLA_087540 {ECO:0000313|EMBL:EAW07048.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW07048.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW07048.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
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DR EMBL; DS027060; EAW07048.1; -; Genomic_DNA.
DR RefSeq; XP_001268474.1; XM_001268473.1.
DR STRING; 344612.A1CUR1; -.
DR EnsemblFungi; EAW07048; EAW07048; ACLA_087540.
DR GeneID; 4699808; -.
DR KEGG; act:ACLA_087540; -.
DR VEuPathDB; FungiDB:ACLA_087540; -.
DR eggNOG; ENOG502QUFK; Eukaryota.
DR HOGENOM; CLU_000211_1_0_1; -.
DR OMA; IFWLLEQ; -.
DR OrthoDB; 2787957at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR InterPro; IPR022099; DUF3638.
DR InterPro; IPR022105; DUF3645.
DR InterPro; IPR046541; DUF6606.
DR PANTHER; PTHR13367; UBIQUITIN THIOESTERASE; 1.
DR PANTHER; PTHR13367:SF28; UBIQUITIN THIOESTERASE ZRANB1; 1.
DR Pfam; PF12340; DUF3638; 1.
DR Pfam; PF12359; DUF3645; 1.
DR Pfam; PF20255; DUF6606; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 9..279
FT /note="DUF6606"
FT /evidence="ECO:0000259|Pfam:PF20255"
FT DOMAIN 2010..2233
FT /note="DUF3638"
FT /evidence="ECO:0000259|Pfam:PF12340"
FT DOMAIN 2350..2382
FT /note="DUF3645"
FT /evidence="ECO:0000259|Pfam:PF12359"
FT REGION 391..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3109..3143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..406
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3118..3143
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3143 AA; 357002 MW; 64B17141B6FA99F8 CRC64;
MDARLLQRVF NHVVLPPMLP GSSDSNVAAI EEDLMQRLLD ASDTLSQLTH NTGDPSWQTL
RRGLETCQRV HIDGQLDRDA LLESFRDIEK TPVILHIAEQ NAGLLLKHEL NDDGEQIIFE
AFEASPKAND VLASSNALFC TFPTTAAAIP RSKFQLTFQD SLASFLHQAS TEPIAMFAAK
AQKAGVSVVE TRDTVDPTLI LHMMMTLIEE IGASTSQLGL QKRIRDEVCW NDAEKPWRRS
PFWLVLRVGV SRLLSSYFGA SKGRIYYKFL LCIVHANLLR HCGATLSLEM TALVRAKLCR
RLAKLEDNRR NAPIGLSETL QQLFEALGPY FETTIHIASG QIDKTWNSFK ESVHPSLKRL
PARANDLDMH LTLTNSLKHL QKALASYRSD INKSKREDKA SKARRLGTPG KDPIVEGTLQ
RLEESSRPLI ALSTREKQLC DAAKASSDVA HLARSIEDYL EHAIRAYEPS IELRSLMTLQ
TFETWIAMDT AATAQNPILK DYHPGFTPEI LDVLLLSSSK DMRRLQRVQK YLADRCANCV
YSKLTIFSDP QKNCLAIRYL QEPANIAAIT QLSMEIDQAC EASRQAKLQQ MNAVNDKYEH
LTREISYMLC SCTRKRSGKK RKNCPVCLIR KKRRGLNIEV HEDFLPSDQP QQKSIQRQAV
LFELIIPSSL AAYRQSTWAI VAALGIPPGA SGSCGPPKIL LSAYRPLNRY WKHKPKTFGL
ASTTKSFLVA HYKGVRPPIT PSQAILPFGL TLQYYDEKQA VWTSEISFPI SLAHHFGLHN
SVLRLLKIED SGVYAADSDG PSSYSAVLSQ TNCPPDLGMH ELAGYQALLY GKHTRWLCIL
RELGSANVNF SREQTMHVFN HRCLQAGPAA SAAEIRIPHI PLGNQGFCHR LLDQIDRHLR
GIRCNWREPY YMDMLLTMVG QVWSLGCTQA SMRSMELLEK IRDITHKWVR DIRDELHNAA
DDEQTTDLTR YALLSGLICK RTFRAIANEP GSFHAEALRC YIEASVCVQE NQLSGLDTQP
AYVRDMLICD IKMTYALRNK VLAAIIAFPC GIEGAIDSIW PSMTGEIRTY GTWKTCGKEQ
NQWVVSEIPP TEYTIGQTIH YHIQHGLVLV NNKPLGRLPR VFLESTAVRT LFGRQSLLVY
PSYLPGMTYM LARQRNSHEF HFGMRGTRVI IRARVARAFL EFIERDVFTS DSDCDLPLPL
VDDCVHWLDL QTNRLDVRPK AHIWAINRRG NWMIDVRNQA GWRRDSRLVD PRSATFRQIA
TIFAHFENRQ YLTVFQPARR TLTVEIKRMG LSFAVNRHGL LQSRELRRVI SLEQDAGTWY
GLQSMLVLHD AGNKQRRSII VPVGPLTYHR RDPHVVLQIV GDGQYALFSI DDVLGRVGCE
PEPLLLFLRA QLHAMTSCPI PDPLTQRTGC EEAMSYLTSS SIQPWTELRP AQLEPLMAIA
RLSPQRFYYP KHLQCQQQVF WDKDLTMSIQ HDGLRALIES ILARLGELAR FSNSNLELSK
LNWKDEPHLR LRAHARRSNF ERPAVSPKPL RHMDDRPYSR ATTDQSYAGI DRVRQIITLI
NTKPQLICTT LNLQATLSQA GNVWGYGQTL ANPLLTDLLQ TDVVTEWGPL VNLCNRNNDE
GKDHLLFQLG LIAFGPNVDM GLFCSAVSFF ILDDLRHLKL PDVSLYNDLA YQKPSVERLV
QLMMAAYDAS DRQLNVHEFN PTYTRQTESE LYERDCRALS GMFIEQWPCP RPQPPEFEGA
LVKGDAAINH IAQEWLHLFE KWQFFRHLDE VQTVLKNHWV AANPRSSGHK YPVKTVLPTR
NCRTLPSLRS LLSASGGPHH ASIDVMSFHQ NSLFPATIVQ ENDVERVQES TQDSEIQELE
EILHKFKSSE NVLRRQYAED LMTSLEGLRA RQTSAGFASK IPPVQAIWGA IFRIKKQLQM
QFGQIQRCLI QNDARYRWLD LGALWPCMSP VTLLERLREA EANTFKSAMK EALFRYALTI
TRLQQLLRMY DAIRKRDSRL LHEELQNPGH DNWRAQDYPD WLLLEIDGNF LIRNGQVDVA
RATISPASGA NSVLQMNMGQ GKTSVIMPMV ACVIADRQSL ARLIIPRALL SQTAQILQSR
LGGLVGREIC HIPFSRKTSN EDTTLSAYRW LHEDMRAKRG IIIAQPDHVL AFRLSGLQAV
CDGRLETALT MTSTQSWLDE TARDVIDECD FTLAVKTQLI YPSGSQLAVD GHPHRWKVAQ
YLLDMAEEHL RDIQNDFSHS VEVTKRPLGG FPFFCFLRPD AERALHTRLV DDICEGRSPH
LVIRGGGDKE AIRIFLTEDK VPEPLVQRAC ASFEIAPSEV QILYLLRGLL VHGILVLCLK
KRWNVQYGLH PERDPIAVPF HAKGVPSEQA EWGHPDVAIV LTCLAFYYDG VTISQVHHCL
RCILQSDDPS SEYDRWIQHS TSLPDSLRHW NLINIDNEMQ VRQIWQHLRF QRILINYYLN
RSVFPAHARQ FEQKLQASGW DIPALHAANN LDMGETTAIT TTRTLTTGFS GTNDNRRLLP
LTITQGDLHG LVHTNADVLT YLLQPRNRGY VLAATSGGKR LSERELLFQL RKMNIKLLID
AGAHILELDN RDLVRLWLEV DYEAPVAVYF RADNKAWVLY RNGKEVPLLA TPFAANLEGC
LVYLDEAHTR GVDLKFPMST QGALTLSLGQ TKDHTVQAAM RLRQLKSTQS VVFFGAPEVH
QSILDRRGKG PIVEVDSGDV VEWLLEQTCT LNEQLQPLYL AQGFDFCRRR QAAAAYPNYP
SNETDRVSYL QAVLLPEQHT LEQLYDPRSV TTLSIDDFQG SGKLRGFWHQ LRGLRQDLQV
KISTTSAFEE VEQERELAVE VEEIRQLHRP ICPIPRKFPG LSPGLARFAK TGALEDSDWC
EPLFQALQRT HLGQKYQICS GRSWSVMVST EFTKATQRAT HQWRDDFLRP VHWILWSPRA
QKAVIVIPEE AEALIPIISK INPPNVHLIV YAAPITKQML HFNHLDYYTI PKFDGIIPTQ
VKIEIGLLAG RLYFEFSECK DIGQYLDTQE EHFSERASSY AFPCVKGFAS QPFAFLEEWF
SVTRKGQDYA HTPMGYICQG RPLRRDHPFF SAATADHSPS ASTVVNMNIS GADGVGPFNE
DSDEDEHFLD DDEDEFVETT EDH
//
