ID A1D147_NEOFI Unreviewed; 4759 AA.
AC A1D147;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Nonribosomal siderophore peptide synthase SidC {ECO:0000313|EMBL:EAW22140.1};
GN ORFNames=NFIA_008170 {ECO:0000313|EMBL:EAW22140.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW22140.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
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DR EMBL; DS027688; EAW22140.1; -; Genomic_DNA.
DR RefSeq; XP_001264037.1; XM_001264036.1.
DR STRING; 331117.A1D147; -.
DR EnsemblFungi; EAW22140; EAW22140; NFIA_008170.
DR GeneID; 4591408; -.
DR KEGG; nfi:NFIA_008170; -.
DR VEuPathDB; FungiDB:NFIA_008170; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000092_1_0_1; -.
DR OMA; ITMIGEK; -.
DR OrthoDB; 1778695at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 3.
DR CDD; cd19542; CT_NRPS-like; 4.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR PANTHER; PTHR45527:SF2; FERRICROCIN SYNTHETASE (NONRIBOSOMAL PEPTIDE SIDEROPHORE SYNTHASE ) (EUROFUNG); 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702}.
FT DOMAIN 853..930
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1980..2056
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3100..3176
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3648..3721
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4205..4278
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3718..3737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4759 AA; 520858 MW; 1C4505C42BB70559 CRC64;
MAGTTNPADK GLTGPTETTN HINSARSDVS LGSSLSGIVP VTKIPALDTI DQYVAEGSPD
DPIGQSPWRR INQGDVSGEL ATGLIEGYAR FVCALTGLED VAFAVLCQAS TRPSQALICA
SVTVTDQEKE VQSAGQCAVR ELDFSYYNRS EVQFALDLAL TGGPENRTTG LSTLAERDCL
SLYVRSSTDG LCISFTYPKR LIPEAAVSQL LKTITFHITQ TTGCLRSTGA WPDDPTPDLS
ILNFPPLMIP PPRDHDSATM SRRSKPFLLH SAFEGWAQKS PTSIALDFVH SLPSGSSMAE
HSTLTYAALN AAATDLAIHI RRLLSDDTRN TGSRIIPVYM STSPELYISY LGILKAGYAF
CPIPTNAPAQ RVCEILQDID SSVILGDAEE PSAAPWLPDA ADETTSKPTW VNVAEVSRWK
HFSGEDTEIA TEDRLFEPPD IDDNEIAYLL FTSGSTGKPK GVQVSHLAVT CSIESHATAI
PLPGTSAGDF RWFQFASPTF DPSLMEIFVT LSSGGTLCSA SRNLTLTDLE GTINEARATV
MMATPSLAAL LRPSRLTTLQ SLWTMGEKLN RTVIENFTQK AHNNDLNGDS VPTSRLLVNA
YGPTEAAINC TFLAPVEYHT RGSIIGEPLP TCSMFVLDPA SHTPKPIPAG LAGELAIGGP
QVSQGYLNRP EETANSFVHS PEYGYLYRTG DLARTVWDEK GAQVIEFLGR ITSDQVKISG
RRVELGEIES VLATLTGVRE VVAVVPKRDA TVQGSEQIVA CIVTDSPTED ALREFVRLAD
ECTHRHLAAY MCPSSYVFFD SIPRTSSGKV DRNSIDSMLQ QGEDSGMKFY MASNEVSEAR
GTARGEWDAL EDEKALELRT LVLNLIAQTT GQDISVIKPN TSLYTLGLDS LGAMRLLQKL
RDQSIHNLSV GDVLQSNTVN GLLALILNGK ANLRGLTHGQ LVDDSCMSLA EHLQAFNDTN
LSTCAERVGI SPEGIQTVLP TTETQSGMLT SFLRTSADSS FATRSYIYHS VISLEPHVDI
ERLKKAWESV IASYDSFRTR FCWIDDGMAP FAQCILKEEA ASAPKWAVYH TSGDSMRKDI
LTGAVREAEN TISLDSPWKL SLLESSADKV IILSMFHGIF DGGSLQLLLE DVSSVYNGQP
PARRTSLEHV VVNHFQANQT ATSNFWKEYL NNYSPIAFPS LTAYRPPAVK TTDCVEITPR
TTHDILKQRS RTIGSTPLSV LQAAWASLLL AYTGTQDQDV VMGSVVSGRF DPDSEICIGP
TFTTIPTRLT LGQIPKAGGK LWTNKSVVAH LASLNAKALS HLQPRLGSLV TAESRLPYDT
VLAYQDFSAG SSTSSIWKTI DHPPMANDYA VMIEVWPAAD SSLTLRASFA LSQLDRDGAE
VMLHQLDDII AFILENPDGD FENALLYTRP DLKALYNPMP KEADEVLDGD LIHTKFEDHA
NSHPDDMALL FKYDLDDDGN PQNISWTYGE LNARADNLAA YLCETYDQLT NTVVPICIEK
SPAMYIAILG ILKAGGAWCP IDTFSPAQRR HDLIKRTGAR VLLVSSEDGE QPKDAIPIDI
DIVDVRKYAD PLVSWPSVGR GSSKKLSSPA GLAYLIWTSG TTGAPKGVPI THSAAVSCFK
SLKKDIPSDV SGGVVRCLQF SQYTFDVSIQ DLFYAWSLGG VLISATREIM LGSFAKLANT
TRATHAHLTP AFAAGVPRNS CETLEVITMI GEKLTQHVAD DWGTNMRAYN TYGPAEVTIV
STVREFGNEY MNIKSANVGW PMESVSVFVT RNRQIVMKNA VGELALGGPQ LSPGYLNQED
VTKAKYVWSE EAGQILYYTG DLVRMLADGS LEFMNRVDDL VKLGGIRIEL SEISFALGGC
HPLVENIETL YIDRPDRPSK VLVAFLSASN ATGADAGDDL LLLNESALQI ALSSREKAHT
ALPAYMIPSV YLVVKRIPRT QSAKTDRRAL QAAYASVDIE DWENRMNPEN NATGHPTDDP
VASNAMEKIV QMIASLINIS PSVITKASRL RSLGIDSIHA VRLASRLKEA GYQLSFIEVI
NCVTVQDLIR LSTSSPEADA APAAEFDINL FNDQWHDIVA SKVDGEFFTV RATPIQESLL
SETMGTYNLY WSNHFFSLDR SVDVTRLKQA WLALCQKNEA LRTGFIPVAE VDNSSRKDDL
DFSILQVLHD HPTLDWEYVV CEEHEWDRLL HSRIEDIIKA HQKTYFKQPP WAVTVLDKGI
ERVMVLTIHH SIHDGPSLDL IEKDLRSAYT GKPPSRYQLR SALSKILLTE EMAAGNRSFW
NSELQKYSEL DAPAWPDLTG KRMPETAAQE HNLISEQIRM TEPLEKLQSI SAELGVSSIA
SLIRAAWGFV SLSYLGVPAA VFAETVSDRV LHADLDNGIG PLISVVPVPF DPKGTAREVL
AEQQRISTQS RKYRHIHARE VRRMLKRPRG EPLYPAVFAF HPAGAEAGAT TDPGLWRELE
DRIGLHVEHP MAFNVLQNAD GSLILEAFSD ASLMSHEHLS IFVRQVDSLV SAMLVNPDKE
LRELINHLPP SLKSKSSQHV TEAVRNSVTL SPTHWLELNA REHPEWTAVE VASSISASGI
EKQSMSYGTL NAAANCVAAF IASLGYKNRM IAVCAGRNLP SYPVIVGVFK SGNTYLPIDD
NLPNDRKAFL IEDGNCPLVF TETAFAATFS DVPETCRVMC IDHPSFVDSL AGMPTDNRAY
ASAPQDNAYL LYTSGSTGKP KGVMVSRANL SAFIESFSEF VCRVAPSTLE LGGRGRYLAQ
ASRAFDVHLL EMFFAWRHGM ASVTAERTML LDDLQLTITK WGITHASMVP SLVDQTNLRP
ELCPELKYLS VGGEKISKRV LDTWAGLPHV ALANAYGPTE VTIGCTFALV GKETTIRNIG
PPLSACACHV LIPGTMDYAL RGQTGELCFT GDIVGNGYLN RPDATGFVQG PDGEKMYRTG
DIGRLMSDDS VEYVGRGDDQ TKIRGQRLEL GEVSEVIRSS SPVEIGVVTT VAKHPGLARP
QLISFIARAG DRSRQRSGDA TIIHSDLATL GKELRDACQR KLPAYMVPEI ILPITFIPLA
PMSGKANIKE LHSMFSSLPL PSILLGNNPG TSDTAAFTGR PLTSDEEAVV NEICAVIRIE
RENINPLTNI FEIGLDSLSA ISLSVKLRRI GYDATVALVM GNPVVEQLAQ LPRKSTEAAA
DPHNSELTKR LAELEAEYHK SYTRAANSGQ VVVRPCLPLQ EGLVARSINS ERDQLYVNHI
ALTLDPGLDS ERLRFAWQDT ADNNEILRTF FAPLEKEIVQ VVLTPGGAMS WTEDAYDSLE
DCITQQRAKQ QEISRGIIKN ITDVPPVRFH LATSSSKHPL VLFIAIHHAL YDGESFSMLL
EDVAARYVGE PVTQRGSPAA FINHVYGQNL EKAQQHWVSS LSDCRPTIFR VDTGVVEETT
FVNRKLGAGL AKLERLSADL HTTVPSLMQA LFALLLADRV NSSDVTYGLV LSGRAVAVPD
ADSVLLPCIT TIPARLNTSG LTTVADVVRS VHQSTARSLE YQHTSLRRIQ RWLKSEKPLF
DCLFSYIRST PAPKQTLWEQ LESTMPSEYP LAVEIEANNE TGEVYVHCGF SPSFGSADRG
QELLEKLDAL LSAFLSGDDI ALDSFSLANS GNSGSPANEV KWDATTWSTT ETKIRDLTAT
FCGLDVVNVS KGTSFLSLGI DSVTAIQFAR KLRELQFEVA PSDIMRFPCV GALAKHIDER
SSGGRQSARS GDKKPRVSLA AHRDNVRLLG DGDSVAAIFE CTPLQAGMIT RTLGSDTQVY
VHPHIVRLTD GVDIDRLNEA IAEVVAKNDI LRTSFHPIAE NGVTWVGAVH ANPPLQWKEI
TLSSNPDVIA ELTSLYSFRE VADFETPPVR FVLAHRESEK VFVVLMHHAL YDGVSLPLLF
EDLTAAYHNQ ATAERPQFSE IAHYIVEGQN DSCDFWTKKL AGYEPVEIPA LSSSDATERM
LLSERKIGLD VEKVVESCKA MEVTVQSVAL LAYAKVLACL VGKRDVVFGQ VLAGRSLPVP
GADQTIGPLF NTVAQRVSFE PKFLSNREIA QRVQQLTSES QAFHHAPLKD VQKALRQEHG
MNAATLFDTL FVFQKSADLT TDTPHEQQIW RPFETDGYAA QAEHKLNVEV DHGREAIFVS
ASGDGRYICQ QALDEFMTDF CTAFQDIIDH PTRCATAAPE RLGGLPLRLS RAEEPERGHS
ESDAPAHEST VRDVLAEVAG VSVDSITPST SIYNIGLDSL SAIRIASICR SRGLKASVAD
VLQGNTLRGI SARIASTVEG LIQPQGPLIE DHEAVEKAVL QRLGLNKDAV ETILPCLSGQ
LYHLASWLKS GRTLFEPAWS YYSSERIDSG KLEEAWNQLR QRHHILRTCF AATSPSMAVQ
IVLKDAPQNA EIFKVIESPA CIEEAAKAQA REEGLNPSSL FVPPVRLRLL KASDKDGIQI
FINHAAYDAW TMPMLVSELA QLYRGQSVES NPDFPSFVEH ATRSLREADE QTYWSSQVGS
SLPTLIKPTY QGLPRQSFVG VWEKVKNLSQ LDRTCRSAGL SLQSVVLLAV SRSLARMTGV
QNPTIGLYQT GRSASFNNIE NLSGPCLNVT PFTFPSPGPT AESNALDQVQ AIQNSLAERV
LYEQSCLRDI LDSWASTKGK GPLFNTWVNL LWMHQPSTRG DSKSHTDLDL FQPLRIGVPT
DFIPATPLPD PSGETTSISA LDTSYLPDEN LYIDIGPDYS TDTIGFGVRV EGGLLTEKEV
HEMVDDVSGE IEGIMAAIQ
//
