GenomeNet

Database: UniProt
Entry: A1D1R8
LinkDB: A1D1R8
Original site: A1D1R8 
ID   DRS1_NEOFI              Reviewed;         819 AA.
AC   A1D1R8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   16-OCT-2019, entry version 74.
DE   RecName: Full=ATP-dependent RNA helicase drs1;
DE            EC=3.6.4.13;
GN   Name=drs1; ORFNames=NFIA_010420;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC
OS   A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC   NRRL 181 / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in ribosome assembly.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with pre-ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX27/DRS1
CC       subfamily. {ECO:0000305}.
DR   EMBL; DS027688; EAW22361.1; -; Genomic_DNA.
DR   RefSeq; XP_001264258.1; XM_001264257.1.
DR   SMR; A1D1R8; -.
DR   STRING; 36630.CADNFIAP00001694; -.
DR   PRIDE; A1D1R8; -.
DR   EnsemblFungi; EAW22361; EAW22361; NFIA_010420.
DR   GeneID; 4591505; -.
DR   KEGG; nfi:NFIA_010420; -.
DR   EuPathDB; FungiDB:NFIA_010420; -.
DR   HOGENOM; HOG000265456; -.
DR   KO; K13181; -.
DR   OMA; HEPERSW; -.
DR   OrthoDB; 268859at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding.
FT   CHAIN         1    819       ATP-dependent RNA helicase drs1.
FT                                /FTId=PRO_0000282493.
FT   DOMAIN      330    504       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      531    678       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     343    350       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       299    327       Q motif.
FT   MOTIF       452    455       DEAD box.
FT   COMPBIAS    180    264       Asp-rich.
FT   COMPBIAS    758    819       Lys-rich.
SQ   SEQUENCE   819 AA;  90304 MW;  A538734C9BA16513 CRC64;
     MAPNATTKKR AAAKDDDFVL TLSDDENDVL ENGVEEDTLS SSKKRKRDAA EAPKGKNKKQ
     KQLKKSKKGE SAAGAVSDDQ SGEEDEAEAM DAGEDDGALD SEFEFDVGGN ANTGVIEGFD
     GWEARNGAGP ADAPKNGDKK AVDIDDIISR RKAKKEAELK KKQQKEKKRR EEEGEEESED
     EDADSDGGMS VDFQDDELLA ADGFGMGADG ADESGDDVEN DSNDSDDADE KGSEDEESDD
     DAAASDNDSV ATPVHHPDDE AASDEESEAE SEVDAEEAEK RKAFFAPEEK STAASTSNRS
     FQDFNLSRPI LRGLASVNFT TPTPIQQKTI PVALLGKDIV GSAVTGSGKT AAFVVPILER
     LLFRPRKVPT SRVAILMPTR ELAVQCYNVA TKLATHTDIT FCQLVGGFSL REQENILKKR
     PDVIIATPGR FIDHMRNSPS FTVDTLEILV LDEADRMLED GFADELNEIL TTIPQSRQTM
     LFSATMTDSV DKLIRVGLNR PVRLMVDSKK NTSMNLTQEF VRLRPGREDK RLGYLLYLCN
     EIYTGRVIVF FRQKREAHRV RIVFGLLGLK AAELHGSMSQ EQRIKSVENF REGKVAFLLA
     TDLASRGLDI KGVETVINYE APQSHEIYLH RVGRTARAGR SGRACTIAAE PDRKIVKSAV
     KAGKAQGAKI VSRVVDPAVA DEWAAKAKGL EDEIEEVLQE EKLEKQMAQA EMQVTKGENM
     IKHEAEIMSR PKRTWFETER DKRAARKLGA TELNGPSKKD KVKLSNKDKK RLDDARQRHE
     GNIGWKKGKA DREAPKQGKN KGSKNKSDKK NNIKMKGKK
//
DBGET integrated database retrieval system