ID A1D1X3_NEOFI Unreviewed; 464 AA.
AC A1D1X3;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE SubName: Full=Cation diffusion facilitator 1 {ECO:0000313|EMBL:EAW22416.1};
GN ORFNames=NFIA_010980 {ECO:0000313|EMBL:EAW22416.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW22416.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS027688; EAW22416.1; -; Genomic_DNA.
DR RefSeq; XP_001264313.1; XM_001264312.1.
DR AlphaFoldDB; A1D1X3; -.
DR STRING; 331117.A1D1X3; -.
DR EnsemblFungi; EAW22416; EAW22416; NFIA_010980.
DR GeneID; 4590987; -.
DR KEGG; nfi:NFIA_010980; -.
DR VEuPathDB; FungiDB:NFIA_010980; -.
DR eggNOG; KOG1485; Eukaryota.
DR HOGENOM; CLU_013430_2_2_1; -.
DR OMA; CWALRNQ; -.
DR OrthoDB; 5479358at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0098771; P:inorganic ion homeostasis; IEA:UniProt.
DR GO; GO:0030003; P:intracellular monoatomic cation homeostasis; IEA:UniProt.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR Gene3D; 3.30.70.1350; Cation efflux protein, cytoplasmic domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027470; Cation_efflux_CTD.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR43840:SF12; CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440); 1.
DR PANTHER; PTHR43840; MITOCHONDRIAL METAL TRANSPORTER 1-RELATED; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR Pfam; PF16916; ZT_dimer; 1.
DR SUPFAM; SSF160240; Cation efflux protein cytoplasmic domain-like; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 173..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 377..449
FT /note="Cation efflux protein cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF16916"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 464 AA; 51810 MW; 7D83C95EAA795E77 CRC64;
MEDSHFRHSI SHHPSPFNPH TLHSHIPRDR ASSALSLNAA TSTALDPSEQ TQPHISQHRT
NPSSDEEGQP PPRYTPENDP FQLASKLKTA EEIRQIQPVA NTSRKRDASS SSTAAAGIKL
RSRNAISDTL ASRQLQGFYK TQNENIERML KPVEEHVRAA RELNSNNALR YRIAVYGSFA
ANVVLSVLQL YGAISSGSLS LFTTMADAIF DPCSNLTLLL CNKAVNRVDP RKFPAGKARI
ETAGNICFCF LMTAVSFILI AFSIRELVEG SDAVTGSFFL PSVIAVVVAF CTKLALFLYC
WALRNQVSQI RILWEDHRND LLINGFGILT SVGGSKLRWW IDPMGAIILS VLISVLWLHT
AYHEFQLLIG VTADTKMQQL ITYISMTHSP YITAIDTVRA YTSGPRLLVE VDIVMDPEES
LRATHDVAEE LQMKLESLPD VERAYVHVDY ETTHKPEHFL KKEL
//