ID A1D2A9_NEOFI Unreviewed; 562 AA.
AC A1D2A9;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=4-coumarate-CoA ligase, putative {ECO:0000313|EMBL:EAW22552.1};
GN ORFNames=NFIA_012410 {ECO:0000313|EMBL:EAW22552.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW22552.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
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DR EMBL; DS027688; EAW22552.1; -; Genomic_DNA.
DR RefSeq; XP_001264449.1; XM_001264448.1.
DR AlphaFoldDB; A1D2A9; -.
DR STRING; 331117.A1D2A9; -.
DR EnsemblFungi; EAW22552; EAW22552; NFIA_012410.
DR GeneID; 4591185; -.
DR KEGG; nfi:NFIA_012410; -.
DR VEuPathDB; FungiDB:NFIA_012410; -.
DR eggNOG; KOG1176; Eukaryota.
DR HOGENOM; CLU_000022_59_2_1; -.
DR OMA; YIMPKFD; -.
DR OrthoDB; 1404660at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05911; Firefly_Luc_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24096:SF149; 4-COUMARATE--COA LIGASE 1-RELATED; 1.
DR PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EAW22552.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 81..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..413
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 464..539
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 562 AA; 62292 MW; 3C72D9D22CDF2041 CRC64;
MPFKSRYHVD IPNTHLASLL LKSPTHPLSS TQRCFSEAAR PNTHYFSTHD FRLWSQRFAA
GLRKAGLQPG DRILLFSGND LFFPVVFMGI IMAGGIFTGA NPTFVARELA FQLQDSGALF
LLCADVSLDV GIEAARIAGL SRDRVFVFNN AIFDGQGEGR KGCRYWGELV ASVEEGRGFV
WDELSTPEEA DRTLALNYSS GTTGRPKGVE ITHKNYVANM LQYNYMFYLN PDWKERSARA
RWLCFLPMYH AMAQNIFIAA ALSREVPVYI MPKFDFIKML EYVEKFRISD LILVPPVVVA
LAKHPAVKSG KYDLSSVEAI GSGAAPLGRE VCEEVEALWP PGRINVKQGW GMTETTCSIL
GWNPAEKSYS ASVGELNANC EAKIMADDGV TEYGRNQRGE LWVRAPNIMK GYWKNPQATK
ETKTADGWLK TGDIAYVDDL GRFHVVDRKK ELIKVKGNQV APAELEALLL EHPAVADVAV
IGVQVNDDER PRAYIVLKPG HDAAADDIVA FMDGKVSAIK RITGGVVFVD AIPKNPSGKI
LRKVLRERAK EETQKNGVTA KL
//
