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Database: UniProt
Entry: A1D373
LinkDB: A1D373
Original site: A1D373 
ID   PRP5_NEOFI              Reviewed;        1193 AA.
AC   A1D373;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   31-JUL-2019, entry version 73.
DE   RecName: Full=Pre-mRNA-processing ATP-dependent RNA helicase prp5;
DE            EC=3.6.4.13;
GN   Name=prp5; ORFNames=NFIA_015590;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC
OS   A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC   NRRL 181 / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: ATP-dependent RNA helicase involved spliceosome assembly
CC       and in nuclear splicing. Catalyzes an ATP-dependent conformational
CC       change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2
CC       snRNP association with intron RNA (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX46/PRP5
CC       subfamily. {ECO:0000305}.
DR   EMBL; DS027688; EAW22866.1; -; Genomic_DNA.
DR   RefSeq; XP_001264763.1; XM_001264762.1.
DR   SMR; A1D373; -.
DR   STRING; 36630.CADNFIAP00002011; -.
DR   PRIDE; A1D373; -.
DR   EnsemblFungi; EAW22866; EAW22866; NFIA_015590.
DR   GeneID; 4591228; -.
DR   KEGG; nfi:NFIA_015590; -.
DR   EuPathDB; FungiDB:NFIA_015590; -.
DR   HOGENOM; HOG000007229; -.
DR   KO; K12811; -.
DR   OMA; SKFHSIR; -.
DR   OrthoDB; 245118at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:1990446; F:U1 snRNP binding; IEA:EnsemblFungi.
DR   GO; GO:1990447; F:U2 snRNP binding; IEA:EnsemblFungi.
DR   GO; GO:1903241; P:U2-type prespliceosome assembly; IEA:EnsemblFungi.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase; mRNA processing;
KW   mRNA splicing; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN         1   1193       Pre-mRNA-processing ATP-dependent RNA
FT                                helicase prp5.
FT                                /FTId=PRO_0000282693.
FT   DOMAIN      588    766       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      793    943       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     601    608       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       557    585       Q motif.
FT   MOTIF       714    717       DEAD box.
FT   COMPBIAS     21    143       Arg-rich.
SQ   SEQUENCE   1193 AA;  131584 MW;  8D14028FB265D984 CRC64;
     MARHGDTRSP SPVGSTYSSS RRSRRDDDRY EKSRRDDGRS YRRSRSPERR YRDRDRDSYR
     RRDRSIDRRD DHRDEDSYRP SRRDRSRDRR RSRDRGDDRD HRRKSRERDY RSRRDDSRDR
     ARRRTDDSAD LKHKSRRDDS RTRNLDSKSR ETSKPSTPAP AAPTEDEKRA ERLAKLEAWK
     QKQAAERERK QREAAAAGGA RSILEEIDRK SGLSPAVGSP QSPAATPTTD ATPAPYAGKF
     DPKAIVRNAV PAPSTPAVLG NDVAVPQSAK ASASLSSMNN HVQANKPPAA ISTASSTLTV
     KRNVGGFGLG ARQVADAEKS SAVKTLGFGE EESKRKKLER LPTPPLEDAK DDTGAVDAAV
     EDEDDVDMQD GGTEEENAAA ARAAAERREE RLQSEALRAQ SKEAAPQPNG DVEMDDVSHQ
     AESEKMEVDA AEEEVDPLDA FMSELAETAP PKKTTGARFA KAKEQQPEAM FGDEHDVDLT
     AVGEGDADDF LAIANKAKKK KDIPAVDHEK MEYEPFRKKF YTEPSNLAEM TDEEAASLRL
     ELDGIKVRGV DVPKPVMKWS QCGLGVQTLD VIHRLGYENP TSIQSQAIPA IMSGRDVIGV
     AKTGSGKTIA FLIPMFRHIR DQRPLENMEG PIGLIMTPTR ELATQIHKDC KPFLKALNLR
     AVCAYGGAPI KDQIAELKRG AEIVVCTPGR MIDLLAANAG RVTNLRRVTY VVLDEADRMF
     DMGFEPQVMK IMANIRPDRQ TVLFSATFPR NMEALARKSL TKPIEIVVGG KSVVAPEITQ
     IVEVRNEDTK FVRLLEILGN LYSDDANEDA RALIFVDRQE AADTLLRELM RKGYPCMSIH
     GGKDQIDRDS TIEDFKAGIF PILIATSVAA RGLDVKQLKL VVNYDAPNHL EDYVHRAGRT
     GRAGNTGTAV TFLTEEQERY SVDIAKALRQ SGQKVPEPVQ KMVDSFLEKV KAGKEKASAS
     GFGGKGLERL DQERDAARMR ERRTYKTGEE GEDEEDKEDK AEKADERFSK VVSSVQSAAA
     AATTPLPGVP KGIDLDGKIT VHRTEKDPAG ASKNPLDKVG SAVADIHARL SRAGVMRSGV
     PIDNRGPDAG AFHATLEIND FPQKARWAVT NRTNVAKILE ATGTSITTKG SFYPAGKEPG
     PGENPKLYIL VEGETELAVT NAMRELMRLL KEGTLAAADS DARAPVGGRY NVV
//
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