ID A1D3S4_NEOFI Unreviewed; 399 AA.
AC A1D3S4;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 88.
DE SubName: Full=Cyclin, putative {ECO:0000313|EMBL:EAW23067.1};
GN ORFNames=NFIA_017680 {ECO:0000313|EMBL:EAW23067.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW23067.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC RNA polymerase II. {ECO:0000256|ARBA:ARBA00025278}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC Mediator complex. {ECO:0000256|ARBA:ARBA00011612}.
CC -!- SIMILARITY: Belongs to the cyclin family.
CC {ECO:0000256|RuleBase:RU000383}.
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DR EMBL; DS027688; EAW23067.1; -; Genomic_DNA.
DR RefSeq; XP_001264964.1; XM_001264963.1.
DR AlphaFoldDB; A1D3S4; -.
DR STRING; 331117.A1D3S4; -.
DR EnsemblFungi; EAW23067; EAW23067; NFIA_017680.
DR GeneID; 4591517; -.
DR KEGG; nfi:NFIA_017680; -.
DR VEuPathDB; FungiDB:NFIA_017680; -.
DR eggNOG; KOG0834; Eukaryota.
DR HOGENOM; CLU_038278_1_0_1; -.
DR OMA; GITWIDN; -.
DR OrthoDB; 1332948at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20546; CYCLIN_SpCG1C_ScCTK2-like_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026:SF112; CTD KINASE SUBUNIT BETA; 1.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 65..164
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 177..263
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..338
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 45465 MW; BA57C295D4F19E92 CRC64;
MASEKKDDST QPAGAEPSLP EPPAIHPSFI QVAKPYIFEQ TIQKCIAAMG VNPLREEALR
LQGVTWIDNV RRVLYLPIRT FNTAVVYYHK FRLLHPDTEY NYMDAAAAAL FTACKIEDTL
KKSREIVCAA YNLKLPPSEH MSPDNPVFEA HARGIIGLER LMLEASGFDF RTRHPQRTLI
KLARHYGLSP KSEVSNLAYR ISQDLYRTFA PIKQTTSTMA FCSLELAGRL LDQRLEPVEQ
GSDYEQWRTS REEVMETLFD LLELYTHNRS STTVGPHFPP DRFLTVRIPL NKEAEAQRLP
RYTHWVEDSR DSKPTNGARD GRDRPAPKNR ERYRDRGAAA APAVHPLTPV AANGERPKAG
ERGRDGAVRF MLDSECAEAE KARVAEYFKI EMEEYEVEE
//
