ID A1D4P0_NEOFI Unreviewed; 1120 AA.
AC A1D4P0;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=DUF726 domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NFIA_020910 {ECO:0000313|EMBL:EAW23383.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW23383.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
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DR EMBL; DS027688; EAW23383.1; -; Genomic_DNA.
DR RefSeq; XP_001265280.1; XM_001265279.1.
DR AlphaFoldDB; A1D4P0; -.
DR ESTHER; neofi-a1d4p0; Duf_726.
DR EnsemblFungi; EAW23383; EAW23383; NFIA_020910.
DR GeneID; 4592235; -.
DR KEGG; nfi:NFIA_020910; -.
DR VEuPathDB; FungiDB:NFIA_020910; -.
DR eggNOG; KOG2385; Eukaryota.
DR HOGENOM; CLU_001695_1_0_1; -.
DR OMA; KEVGWEV; -.
DR OrthoDB; 8526at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035650; F:AP-1 adaptor complex binding; IEA:EnsemblFungi.
DR GO; GO:0035652; P:clathrin-coated vesicle cargo loading; IEA:EnsemblFungi.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF3; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 541..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 984..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1120 AA; 121617 MW; 62C88AEC6D582148 CRC64;
MTSPSRTAID HSVDSSADPP QSGSQASGVT QSSAAATLPN IDQTDDRRNG EAEVKTPEGK
NPGVSPTLGD NKADADVAEE LDDFGLPIPV RSKAACQLED EPPEEDERFH DVKETRLPSP
KSETTTSEND KRAASHDLSS ENDRQSTPPP AYSSLDIHDS VHQSSPTHKR HSSLKPSEWS
HQRLSENKAV NSESDDESDG EWKEMPALGE FDVYDDYGRL IARGAKEEGD DAVYQGLGGA
GKGYTRVQLD EDAQSATSLD QDTSYLFKEA AGNSVGVEGE ELRDPLSQLQ ATKDLLTESQ
RIAYVGVTRL VIYQMTQDLE KLPTTKASRK AKQKAADAMR KWGQTVMGRI YTHMEIDPAE
QIMIEQLAEH GVQPADLVRP LMQNARVKNP MAEELDSPKA SLSSSASRGL KGNSRASLST
ESELTSESTS PPPYETHEDD DLPEVRTPSQ MPTSAKIDID LRWTVLCDLF LVLISDSAYD
ARSRSLLERV GQSMEVSWLQ IARFEKRVID ALEMQEAAEK ETWDESGHME KRRKMALKRK
YMVMGLATVG GGLIIGLSAG LLAPVIGAGL AAGFTTVGIS GTSAFLGGAG GTALIASGAT
LTGSTIGLRA SHRRTGAVRT FEYRPLHNNK RVNLIVAISG WMTGKVDDVR LPFSTVDPIM
GDIYSVLWEP EMLQSMGATI NILATEALTQ GLQQVLGSTV LMALMASLQL PLVLTKLSYL
IDNPWNVSLA RANAAGLILA DSLMDHNLGK RPVTLLGFSL GARVIFSCLK ELADKGASGL
VQNVYLFGAP LVANKDEFIK ARSVVSGRFV NGYSSNDWIL GYLFRATSGG IMRVAGIAPV
EGIPGLENFD VTNLVNGHMD YRAAIPRLLK EVGWEVLSEE FAEIEDADPE NHGERQRELI
REIDEARKAA EAQPEKKRFG LFKRGKLAEK KGWETYDVKR SDSFPRESTD SNGTGTVLFD
IDAIRAELAS EMIEVKQLES TLPPMKLDLN SPSTQSPAAA TPSEHRASKD GHATPSVPQT
PIENSPGHSA PQKTQSPPPH QEQIHMAFDT SYDNPPQRSH SSFEPAAYDS CPTRPALRSS
VTMPTSVGAS ALGAMALEPN AWADHDFGHG EEGEISMTFE
//