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Database: UniProt
Entry: A1D6X9
LinkDB: A1D6X9
Original site: A1D6X9 
ID   DBP8_NEOFI              Reviewed;         526 AA.
AC   A1D6X9;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   16-OCT-2019, entry version 72.
DE   RecName: Full=ATP-dependent RNA helicase dbp8;
DE            EC=3.6.4.13;
GN   Name=dbp8; ORFNames=NFIA_066370;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC
OS   A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC   NRRL 181 / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in 40S ribosomal
CC       subunit biogenesis and is required for the normal formation of 18S
CC       rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required
CC       for vegetative growth (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX49/DBP8
CC       subfamily. {ECO:0000305}.
DR   EMBL; DS027690; EAW21473.1; -; Genomic_DNA.
DR   RefSeq; XP_001263370.1; XM_001263369.1.
DR   SMR; A1D6X9; -.
DR   STRING; 36630.CADNFIAP00006110; -.
DR   PRIDE; A1D6X9; -.
DR   EnsemblFungi; EAW21473; EAW21473; NFIA_066370.
DR   GeneID; 4589684; -.
DR   KEGG; nfi:NFIA_066370; -.
DR   EuPathDB; FungiDB:NFIA_066370; -.
DR   HOGENOM; HOG000268802; -.
DR   KO; K14778; -.
DR   OMA; TEHPIDQ; -.
DR   OrthoDB; 744428at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    526       ATP-dependent RNA helicase dbp8.
FT                                /FTId=PRO_0000281712.
FT   DOMAIN      127    306       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      338    485       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     140    147       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        96    124       Q motif.
FT   MOTIF       249    252       DEAD box.
SQ   SEQUENCE   526 AA;  57115 MW;  CCD71C3474049941 CRC64;
     MASPVPSEPV SEDTHDSSSG SEVEQSEIST RAPKRRRLSE SSDDSDDSYV APAPLPTLSR
     IKKKGAPDAK PAAPAGQDNP VLIRDALEIG LREEASSFAA LNVAPWLVGS LTTMAVRKPT
     AIQKACIPEI LKGRDCIGGS RTGSGKTIAF SVPMLQKWAE DPFGIFGVVL TPTRELALQI
     FEQIKAISAP QSMKPVLITG GTDMRPQAIA LAGRPHVVIA TPGRLADHIK SSGEDTVCGL
     KRVRMVVLDE ADRLLASGPG SMLPDVETCL SALPPSSERQ TLLFTATVTP EVRALKNMPR
     SANKPPVFVT EISTENQGSI PPTLKQTYLK VPLTHREAFL HVLLSTEDNA SRPAIIFCNH
     TKTADLLERM LRRLTHRVTS LHSLLPQSER NANLARFRAS AARILVATDV ASRGLDIPTV
     SLVINYDVPR NPDDYVHRVG RTARAGRSGE AITLVGQRDV QLVLAIEERV GRQMEEWSEE
     GVSIEGRLVR TGVLKEVGEA KREAMGEIDE GRDVLGRKRN KLKKVR
//
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