ID A1D8B3_NEOFI Unreviewed; 683 AA.
AC A1D8B3;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN ORFNames=NFIA_071280 {ECO:0000313|EMBL:EAW21957.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW21957.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
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DR EMBL; DS027690; EAW21957.1; -; Genomic_DNA.
DR RefSeq; XP_001263854.1; XM_001263853.1.
DR AlphaFoldDB; A1D8B3; -.
DR STRING; 331117.A1D8B3; -.
DR EnsemblFungi; EAW21957; EAW21957; NFIA_071280.
DR GeneID; 4590500; -.
DR KEGG; nfi:NFIA_071280; -.
DR VEuPathDB; FungiDB:NFIA_071280; -.
DR eggNOG; KOG2315; Eukaryota.
DR HOGENOM; CLU_013809_0_1_1; -.
DR OMA; WNPNSKE; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT DOMAIN 218..412
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 478..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 73864 MW; 179457D98CA88689 CRC64;
MAAPQQLAFR TVKGIGILDA APVYEPLSGF VRPEGNLRCS AYSPCGRYFA WASPERVTIV
DPSVGQVVST ISAENVFELG FSPLGTYLIT WQRPSKDANG DAVKNLKVWK VIETSPETNG
DEHTVVGSFV QKSQTGWNLQ YTFDESLCAR VVTNEVQFFQ SDNLSKVWNK LRVEGVSDFA
LSPGKNNSIA VFIPERKGQP AAVKVFNVPQ FGAPISQKSF FKGDKVQLKW NSNGTTLLVL
AQTEVDRSGK SYYGETTLYL LSANGGFDSR VDLDKEGPIH DVSWNPNSKE FGVVYGYMPA
KTTIFNFRGV AKHSFPLAPR NTILFSPHGR FVLVAGFGNL AGQMDIYDLD KNYNKVATVE
ASNASVCEWS PDGQFILTAT TSPRLRVDNG IRIWHVSGGL MYNEDMNELY EVVWRPQSTT
QHPLGDPFQT LPTPHPSALA YLSTKKAPAK PVGAYRPPGA RGQVTPLAFK REDEGGAAYV
RDGASGGSAL NGFGKPRRRE VPGAEPVEEY LPPGAAPGGG VALPPGADQE KLSRSAAKNK
KKREAKKQQQ QDGLAPPAHG GQSGQSPDRR GHERSRSKGQ NGHVDGNARR NGHQANGASQ
SAKTKPAEAP APAPAPAAPA AADAAANPTA QDKKIRGLLK KIRAIEELKM RLAGGEKLED
TQVKKIQTED SVRKELEALG YNG
//
