ID A1DBG1_NEOFI Unreviewed; 525 AA.
AC A1DBG1;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Acetyl-CoA hydrolase {ECO:0000256|ARBA:ARBA00017958};
DE EC=3.1.2.1 {ECO:0000256|ARBA:ARBA00011920};
DE AltName: Full=Acetyl-CoA deacylase {ECO:0000256|ARBA:ARBA00029672};
GN ORFNames=NFIA_098300 {ECO:0000313|EMBL:EAW20201.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW20201.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O = acetate + CoA + H(+); Xref=Rhea:RHEA:20289,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=3.1.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001831};
CC -!- SIMILARITY: Belongs to the acetyl-CoA hydrolase/transferase family.
CC {ECO:0000256|ARBA:ARBA00009632}.
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DR EMBL; DS027694; EAW20201.1; -; Genomic_DNA.
DR RefSeq; XP_001262098.1; XM_001262097.1.
DR AlphaFoldDB; A1DBG1; -.
DR STRING; 331117.A1DBG1; -.
DR EnsemblFungi; EAW20201; EAW20201; NFIA_098300.
DR GeneID; 4588344; -.
DR KEGG; nfi:NFIA_098300; -.
DR VEuPathDB; FungiDB:NFIA_098300; -.
DR eggNOG; KOG2828; Eukaryota.
DR HOGENOM; CLU_019748_3_0_1; -.
DR OMA; DEALSWH; -.
DR OrthoDB; 100792at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0008775; F:acetate CoA-transferase activity; IEA:InterPro.
DR GO; GO:0003986; F:acetyl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006083; P:acetate metabolic process; IEA:InterPro.
DR Gene3D; 3.30.750.70; 4-hydroxybutyrate coenzyme like domains; 1.
DR Gene3D; 3.40.1080.20; Acetyl-CoA hydrolase/transferase C-terminal domain; 1.
DR Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 1.
DR InterPro; IPR026888; AcetylCoA_hyd_C.
DR InterPro; IPR038460; AcetylCoA_hyd_C_sf.
DR InterPro; IPR046433; ActCoA_hydro.
DR InterPro; IPR003702; ActCoA_hydro_N.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR43609; ACETYL-COA HYDROLASE; 1.
DR PANTHER; PTHR43609:SF1; ACETYL-COA HYDROLASE; 1.
DR Pfam; PF13336; AcetylCoA_hyd_C; 1.
DR Pfam; PF02550; AcetylCoA_hydro; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EAW20201.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702}.
FT DOMAIN 13..230
FT /note="Acetyl-CoA hydrolase/transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02550"
FT DOMAIN 333..483
FT /note="Acetyl-CoA hydrolase/transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13336"
SQ SEQUENCE 525 AA; 58177 MW; AC70F1592EDA0FAB CRC64;
MAASALLKSR VRRPSYLQKL AKAEDLIDLF PHGSYIGWSG FTGVGYPKKV PTALADHVEK
NNLQGKLQYT LFVGASSGAE TENRWARLNM IERRSPHQVG KEIAKGINNG QIKFFDKHLS
MFPSDLVYGW YTLNKPKNRL DVAVIEASAI TEDGGIIPGA SVGASPELIQ MADKIVIEVN
TASPSFEGLH DITMSEVPPR RKPYLIMQPE DRIGTPHIPV DPEKVVAIVE SDYPDQTQPN
APEDATSQAI ASNLIEFLKH EVRHGRLPQN LLPIQSGIGN IANAVIGGLS KGGADFTNLK
VWTEVLQDSF LDLFDSGNLD FATATSIRFS PDGFKRFYDN WEHYAGKLLL RSQQVSNSPE
IIRRIGCIGM NTPVEVDIYA HANSTCVMGS RMLNGLGGSA DFLRNSKYSI MHTPSTRPSK
IDPTGVSCIV PFCTHIDQTE HDLDVVVTEQ GLADVRGLSP RERARVIIKQ CAHPDYQPIL
TDYMDRAEYE CLKKGMGHEP HLLFQAFKMH QNLQEKGTMK ITGWD
//
