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Database: UniProt
Entry: A1DE84
LinkDB: A1DE84
Original site: A1DE84 
ID   DBP7_NEOFI              Reviewed;         758 AA.
AC   A1DE84;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   16-OCT-2019, entry version 72.
DE   RecName: Full=ATP-dependent RNA helicase dbp7;
DE            EC=3.6.4.13;
GN   Name=dbp7; ORFNames=NFIA_076210;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC
OS   A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC   NRRL 181 / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- MISCELLANEOUS: Present with 1460 molecules/cell in log phase SD
CC       medium.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX31/DBP7
CC       subfamily. {ECO:0000305}.
DR   EMBL; DS027696; EAW17691.1; -; Genomic_DNA.
DR   RefSeq; XP_001259588.1; XM_001259587.1.
DR   SMR; A1DE84; -.
DR   STRING; 36630.CADNFIAP00007501; -.
DR   EnsemblFungi; EAW17691; EAW17691; NFIA_076210.
DR   GeneID; 4586305; -.
DR   KEGG; nfi:NFIA_076210; -.
DR   EuPathDB; FungiDB:NFIA_076210; -.
DR   HOGENOM; HOG000268799; -.
DR   KO; K14806; -.
DR   OMA; FSRIQWL; -.
DR   OrthoDB; 973872at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR025313; DUF4217.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF13959; DUF4217; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01178; DUF4217; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    758       ATP-dependent RNA helicase dbp7.
FT                                /FTId=PRO_0000281709.
FT   DOMAIN      171    372       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      398    603       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     184    191       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       138    167       Q motif.
FT   MOTIF       308    311       DEAD box.
SQ   SEQUENCE   758 AA;  83538 MW;  696DE784DFAB1694 CRC64;
     MADDGLLLNF SLGDNNIIQP ETKLKGGTWR DRLSAKKIAK HHAKGPRTAG DEDSTPRAPR
     NPNRIEVPSS RPTKRQRTDG GDSGKQQSHT HPHSNQPRQF ISSLFTKNPE PQKVEEVKEE
     GHVEDAKPTN APLIDGLDTF TNLGLSPSLA AHLLTKLELK APTAIQKASI SQLLKEEGDA
     FIQAETGSGK TLAYLLPLVQ RIMALSKPGA QTDAKGQPIV HRDSGLFAIV LAPTRELCKQ
     ISVVLENLLR CAHWIVAGTV IGGEKKKSEK ARLRKGLNIL VATPGRLADH LDNTQALDVS
     NVRWLVLDEG DRLMELGFEE EIQGIVKKLD ARQRPSRIPG VPTRRTTILC SATLKMSVQK
     LGEISLKDAV HIKADPEDED EKARRSKEEE SAYRVPAQLK QSYAVVAAKL RLVTLTAFFK
     RTFMRKGSVM KAIIFVSCAD SVDFHFEVFT RKQAKEDGDE SSDTDKSEDK PPSSPHGTIA
     PATAFSNPSN PVTLFRLHGS LPQNVRTSTL GAFAKNKEAS VLICTDVASR GLDLPNVDLV
     VEYDPAFSAE DHLHRIGRTA RVGRDGRALI FLQPGCEENY VEVLKRGYRD GGKALTRADA
     NDILKRGFGG NVESGNKDWE TKATDWQCEI ERWALENPEY LEMARRAFQS HIRAYATHIA
     AERSMFNIKE LHLGHLAKAF ALRDRPSKIN VPGLRQGKEE TKKDFKAERN SAAGKKRKAG
     GTDLADDIPS ANNTATAAQK MRAKMKEHIS GANEFNLA
//
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