ID A1DEL3_NEOFI Unreviewed; 2119 AA.
AC A1DEL3;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=separase {ECO:0000256|ARBA:ARBA00012489};
DE EC=3.4.22.49 {ECO:0000256|ARBA:ARBA00012489};
GN ORFNames=NFIA_077600 {ECO:0000313|EMBL:EAW17820.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW17820.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=All bonds known to be hydrolyzed by this endopeptidase have
CC arginine in P1 and an acidic residue in P4. P6 is often occupied by
CC an acidic residue or by a hydroxy-amino-acid residue, the
CC phosphorylation of which enhances cleavage.; EC=3.4.22.49;
CC Evidence={ECO:0000256|ARBA:ARBA00000451};
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DR EMBL; DS027696; EAW17820.1; -; Genomic_DNA.
DR RefSeq; XP_001259717.1; XM_001259716.1.
DR STRING; 331117.A1DEL3; -.
DR EnsemblFungi; EAW17820; EAW17820; NFIA_077600.
DR GeneID; 4586190; -.
DR KEGG; nfi:NFIA_077600; -.
DR VEuPathDB; FungiDB:NFIA_077600; -.
DR eggNOG; KOG1849; Eukaryota.
DR HOGENOM; CLU_000454_0_0_1; -.
DR OMA; CAVTFLM; -.
DR OrthoDB; 5479815at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0098813; P:nuclear chromosome segregation; IEA:UniProt.
DR GO; GO:0000280; P:nuclear division; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005314; Peptidase_C50.
DR InterPro; IPR030397; SEPARIN_core_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12792; EXTRA SPINDLE POLES 1-RELATED; 1.
DR PANTHER; PTHR12792:SF0; SEPARIN; 1.
DR Pfam; PF03568; Peptidase_C50; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51700; SEPARIN; 1.
PE 4: Predicted;
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702}.
FT DOMAIN 1915..2010
FT /note="Peptidase C50"
FT /evidence="ECO:0000259|PROSITE:PS51700"
FT REGION 41..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1470..1505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2058..2087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2064..2085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2119 AA; 235011 MW; 86446B7FF5D32A09 CRC64;
MAVATLLPES SLDSVKQAVR STSTCCNATV LSLQSLFRGS TKPVPDIESE SMKKTSRTKK
AVSASSRRSR ATIKTNVSAK GATTIAAVEH DAARLSCQEK VSLATEIFNT TLKTLADASK
SSEIRVPTTP LHPASPNRVT KPARRSKTPQ CVKPDAAKID GGLLAVAECA SLALACLRNM
KAEQSSQGNG PLNIQLEQGA CVLAGRYLSL GLNDLAYKEL RGLKRRVHQY LDCQDTGKDG
TVGRKDQRST EEEAAKERMS DLISFKNLSH ARPLHSLIIS FQSNALRLIA AEKRAATVHK
VLTSLQLTNP SSPANLITAA VDSQTITRDK AAMQLQLLSN TILSMCSATQ KPNDINATKE
SLKPITSLTL QLLSLEIRCM SWKLSGHVCD DVKEMWEPLA RYLAAFVNHS KGIEKAEFAA
TYKTIVRLQA AVANSQKRPS SKLRNNLSVA RIATILGQLA QEAGCFEEAS TLFTEALNPL
ADENLLSSAT VRCKLAALHL QALKSSTKMR QPSVPMSLSE VTAAIGTPLR GNENDLDELL
VEAAKLKKIA MSWLGEKVAK GLDATDEERE VLPNIYAYLN GFVRFLRRYL GKKPAADEDQ
MDLEVFYKRL ETCRSIVLAA VDSALAVGKL SIMSQSPSWE SLLSTFSDCQ RLLVAIECTA
EGKQERSDEN ESGTGFVKLS NLFWSRYIKD KESGKGYREL MHALRQSINF LENCSPAQRR
TGFAALKYER LAHLYLEANM GVECAEAFRA SLNEHISAGV LKQLVSDAVG VSPHRACQDS
KSSSFTFNRI LSAFLRTSLR LRDLNHAKFF DCPTLESLQR GLLLEWQLGI LSDLPSQAHD
DEGFRSAFDT LLSTVLEVYS PESRPIRRLR VILMGLRFSL EHSGSLEQPT VRRLVEESVK
CLDNAQEIGS DTDVELYATH LKNSVCLTLG LHEGDLRSDE LDRILRSWNS MMRNCPDKDT
LSSCVDDVDY YFLQVKAIVD YTEIYGLWKL QLVALELVLR ITEVQGTRDF SAAIIILSRL
VSQYCRLGHC KKAEALLTRA DRYLNENEVS CLANLSYRLA RVEYLLERGE LEKAAGILST
SRLLYEKNQK KEDLSNGSIL SKIGWERLVA DAVLMSSRLS FAQGSVTQAL FFAKLCVKLN
CRIWAKVERI SQRKQEKSLS ASRSSDLESV VDRVARLDVS QSESTTNHTV TYSQGAPFWP
HVGSHHTALL NLAYFSAHYG LFQDAVYYGE QALKINRTLN ANVRLIASQA QLGSYWIFGG
RLSEGQELLA AAEQLSKQLE SSVELASLQM SIASLHRLQG NYHDEWQALL RADRIMADVT
ALETTEPLPL QSTISELEDG MDKLKIRGSS RRAQPSTTTA RRTRATTVSS RTAPKPLTSK
PDANGTMSQS VSYLRSGILQ QQAACSRALR EFEKASRLLT DARKFATSRN SQISLHLKES
EHHLAEAIRQ FASHAVYCVL PESTISLPAL QSPRKVTNET TPSTKQSTTR KSRAPARGTR
SKHAKPNEDF IDILSKAGDC LKDVFSAATA LGSTLDSHMA SRLMSRISML SHTTAPGSPM
PWSQPPANVN EIGRIGAFSR ERIAIGIDRQ LSDFNDPLLW PAQGSTAEPD ADLCSTFTEE
YIDILPSNWN VLSLSLSADC TEFIISRLRK DHSPFLLRLP LKRGNAEDDE DQFTFEDGRG
EMQEIIKLAN ESAHAAKLQK DRHSKKEWWR NREALDQRLQ NLLQNIENVW FGGFRGIFSP
MSHEEAALSR FATSFQSILD KHLPSRQKGG RSATPRLSLH RNVLELFVGV NDLEGQEDPE
ETLMDLLYFV VDILQFQGER NAYDEIDFDM MVVETLDAVQ GYHEAARRSR EGQRPQHTVL
VLDKALHLFP WESLPCLEGL PVCRVPSLEC LRERILQSES IIKLKGSDIG FAIDRGNGTY
ILNPTGDLQT TQATFEADLG RLATWTGIAK REPTEEEFKD GLESKSLFLY FGHGSGAQYI
RGRTIKRLDR CAVTFLMGCS SGTLTEAGEY EPYGTPMNYL HAGCPALVAT LWDVTDKDID
RFAKSTFEKW GLIGDRDTNG ERTTLPSKGR SRSAKKSSTE SSDPVMLDEA VSKSRSACVL
KYLNGAAPVI YGIPSVFLE
//
