ID A1DH15_NEOFI Unreviewed; 299 AA.
AC A1DH15;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Alcohol dehydrogenase, putative {ECO:0000313|EMBL:EAW18672.1};
GN ORFNames=NFIA_086270 {ECO:0000313|EMBL:EAW18672.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW18672.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072}.
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DR EMBL; DS027696; EAW18672.1; -; Genomic_DNA.
DR RefSeq; XP_001260569.1; XM_001260568.1.
DR AlphaFoldDB; A1DH15; -.
DR STRING; 331117.A1DH15; -.
DR EnsemblFungi; EAW18672; EAW18672; NFIA_086270.
DR GeneID; 4587127; -.
DR KEGG; nfi:NFIA_086270; -.
DR VEuPathDB; FungiDB:NFIA_086270; -.
DR eggNOG; KOG0023; Eukaryota.
DR HOGENOM; CLU_026673_20_1_1; -.
DR OMA; CEICAVN; -.
DR OrthoDB; 5295198at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42940; ALCOHOL DEHYDROGENASE 1-RELATED; 1.
DR PANTHER; PTHR42940:SF2; DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006702}.
FT DOMAIN 36..138
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 182..283
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 299 AA; 32153 MW; 376680819579A83E CRC64;
MAVPQTQIAA VVSGPSKSSS ARVDIISERP VPSPKQGEVL IKLEYSGVCH SDVHSIRGDT
LMLTDVAGHE GVGKVIQGEA HRADLQCLTD LLIWLYSSCL KCEICAINHT ACPYQKNAGA
NVPGTFQQFI VSPAEHVTII PPELDPDTAA PLLCAGIAMY SSIMKTKTRP GDWIVILGAG
GGLGHMGIQI AVKKGLKVIA IDSRDKKREL CLSLGATDYF DYKKDDIAAR VKSVTRGLGA
HAVICTANSE SAYIQSMQML RRLGVLVCVG IPNKPFRLPS TPLDMIVKGM ERPRRCQAH
//
