ID A1DHY1_NEOFI Unreviewed; 527 AA.
AC A1DHY1;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Translation initiation factor eIF-2B subunit family protein {ECO:0000313|EMBL:EAW18988.1};
GN ORFNames=NFIA_089450 {ECO:0000313|EMBL:EAW18988.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW18988.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; DS027696; EAW18988.1; -; Genomic_DNA.
DR RefSeq; XP_001260885.1; XM_001260884.1.
DR AlphaFoldDB; A1DHY1; -.
DR STRING; 331117.A1DHY1; -.
DR EnsemblFungi; EAW18988; EAW18988; NFIA_089450.
DR GeneID; 4587443; -.
DR KEGG; nfi:NFIA_089450; -.
DR VEuPathDB; FungiDB:NFIA_089450; -.
DR eggNOG; ENOG502SIEX; Eukaryota.
DR HOGENOM; CLU_021101_1_0_1; -.
DR OMA; NTYFEWV; -.
DR OrthoDB; 1406448at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR43475; METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR43475:SF3; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290); 1.
DR Pfam; PF01008; IF-2B; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000313|EMBL:EAW18988.1};
KW Protein biosynthesis {ECO:0000313|EMBL:EAW18988.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702}.
FT DOMAIN 6..153
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
SQ SEQUENCE 527 AA; 58844 MW; ED09BFAA29E4FAAD CRC64;
MADLKQKRDV VSSLIFKFPD EESSKPKVAL FRRSDKVRTY PHHLAPISGN IDSTDKDPLT
AAWRELHEET TLTPTNLTLW RVGKPFTFSD PTLNREWTVH PFAFKLKPAS QGGQGEAAIQ
TEWEHESWEW HDPASIVDDE AFGGVPRLHE TLRRVFPECE MDERAGETLA RGLERLQQDH
KSGAHELTGI ALAIFREIIA QTHEIDEGWW RTVRMAAWHL IKNGRESMGA ATLNALLSIL
ATLDKIVNQP TGAEQDQKPD WILSTIDSHL ANRTANTTRL KDAFTSYIQT TFLTTEPKRG
RITMLTLSAS STTRNIILDA FAALDIPTLE LRILESRPLF EGATLASSIY SRFQSQFGST
DKKLDIKIYT DAAAALAAQD IDIVLLGADR ICSSKGVSNK TGSLPVVLST KHVTPSAKIL
VLSQLEKVVG DDGILEDKVE DNDPDEVFSA WRNERVEGTQ VLEDSFSGSE TNRDEPATIQ
VKNTYFEWVP LTLVDAFVSD EGVLDEATIK NKSQQLGKLA CKYFDDL
//
