ID A1DJ07_NEOFI Unreviewed; 334 AA.
AC A1DJ07;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=3-beta hydroxysteroid dehydrogenase/isomerase family protein {ECO:0000313|EMBL:EAW19364.1};
GN ORFNames=NFIA_093270 {ECO:0000313|EMBL:EAW19364.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW19364.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily.
CC {ECO:0000256|ARBA:ARBA00023445}.
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DR EMBL; DS027696; EAW19364.1; -; Genomic_DNA.
DR RefSeq; XP_001261261.1; XM_001261260.1.
DR AlphaFoldDB; A1DJ07; -.
DR STRING; 331117.A1DJ07; -.
DR EnsemblFungi; EAW19364; EAW19364; NFIA_093270.
DR GeneID; 4587819; -.
DR KEGG; nfi:NFIA_093270; -.
DR VEuPathDB; FungiDB:NFIA_093270; -.
DR eggNOG; KOG1502; Eukaryota.
DR HOGENOM; CLU_007383_9_2_1; -.
DR OMA; ICCAYNT; -.
DR OrthoDB; 1848657at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR PANTHER; PTHR10366:SF812; PUTATIVE-RELATED; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:EAW19364.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702}.
FT DOMAIN 6..253
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 334 AA; 36145 MW; A87B31A3E034461A CRC64;
MPSGLIFITG ATGFIGSAVA LEALKAGYSL RISIRKESQI PKLKKILSQF EDKIEFIVVP
DITQESSFAG KLDGVDYVLH LASPLPHGTN KETYFGPAVK GTTAILKEAA KVSTVKRVVI
TSSMAALIPL TGVPEGAFVR EDNGWDLTVD PNADFTGPDN AATSFSLYHA SKLLANNASW
EFKNTEKPHF SLVTLHPAYV FGHNHVQTSL EEVQGGTNGM LWGTIMTGKP LGNITGVHVR
DVAEAHIKAL DETVPDGSKF LLAGKKASWS DVARIVKRDY PAIGAKITED ISGEPYPLDT
TEAEKVLGMK WRSLDQMVKD VLDQQLGLMR QATL
//
