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Database: UniProt
Entry: A1DMT9
LinkDB: A1DMT9
Original site: A1DMT9 
ID   MAK5_NEOFI              Reviewed;         777 AA.
AC   A1DMT9;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   31-JUL-2019, entry version 72.
DE   RecName: Full=ATP-dependent RNA helicase mak5;
DE            EC=3.6.4.13;
GN   Name=mak5; ORFNames=NFIA_054560;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC
OS   A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC   NRRL 181 / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX24/MAK5
CC       subfamily. {ECO:0000305}.
DR   EMBL; DS027698; EAW16110.1; -; Genomic_DNA.
DR   RefSeq; XP_001258007.1; XM_001258006.1.
DR   SMR; A1DMT9; -.
DR   STRING; 36630.CADNFIAP00004212; -.
DR   EnsemblFungi; EAW16110; EAW16110; NFIA_054560.
DR   GeneID; 4584522; -.
DR   KEGG; nfi:NFIA_054560; -.
DR   EuPathDB; FungiDB:NFIA_054560; -.
DR   HOGENOM; HOG000290702; -.
DR   KO; K14805; -.
DR   OMA; HANMIQK; -.
DR   OrthoDB; 973872at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    777       ATP-dependent RNA helicase mak5.
FT                                /FTId=PRO_0000282487.
FT   DOMAIN      232    444       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      496    646       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     245    252       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       201    229       Q motif.
FT   MOTIF       370    373       DEAD box.
SQ   SEQUENCE   777 AA;  84961 MW;  6918FB8D8CFA416C CRC64;
     MGQKRQRDSK SSTFHAKKRK KAENATAPDS DDGWDGIVGA DELNWKEVAL PDHLEDAGGF
     FGLEEIEGVD IVRGSGNGEV KFKAVAGKPK KSILKKKAPE DENSEYDEEW SGFSDDDADR
     PENASSPAVE KPEKSDTKAD KKSEKNADKK EAKDAKKKEA KAAKKEQKEK GSAIQHDTSI
     NAGLSFAALQ DTEEDDGADV SAWDSLGLSP EILTGLSKMK FASPTSVQEA CIPQILEGHD
     VIGKASTGSG KTLAFGIPIL EHYLEKKRDD ISAEKEKKSE KDSTPIALIL SPTRELAHQL
     SKHIGELIAQ APGVNARIAL LTGGLSVQKQ QRLLSGADIV IGTPGRVWEI LSTGQGLIRK
     MQQIKFLVVD EADRLLSEGH FKEVEEILNA LDRVEDGEVP GGENQASEEE SDPSSERQTL
     VFSATFHRDL QQKLAGKGKW TGGDVMDKKE SMDYLLQKLN FREEKPKFID MNPISQMADN
     LKEGIVECGA MEKDLFLYTL LLYHPKHRTL VFTNSISAVR RLTKLLQTLQ LPALALHSSM
     AQKARLRSVE RFSSPSSDPS TILVATDVAA RGLDIKGINL VIHYHAPRTA DTYVHRSGRT
     ARAGASGKSV IICGPDEMVG VVRLAAKVHA NMANGKKLPL ESLELDRRVV SRVKPRVSLA
     SRITDANIAK EKISAEDNWL RNAAEDLGVE YDSEEFDESN GKGRGRGRGR HQKQKEVGSV
     SKAELAGLRA ELKQLLSQRV NVGVSERYLT AGRVDIDALL RGEGNASFLG PVDPLHF
//
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