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Database: UniProt
Entry: A1DNG2
LinkDB: A1DNG2
Original site: A1DNG2 
ID   DBP10_NEOFI             Reviewed;         934 AA.
AC   A1DNG2;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   16-OCT-2019, entry version 73.
DE   RecName: Full=ATP-dependent RNA helicase dbp10;
DE            EC=3.6.4.13;
GN   Name=dbp10; ORFNames=NFIA_056820;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC
OS   A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC   NRRL 181 / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P.,
RA   Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A.,
RA   Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A.,
RA   Galens K., Fraser-Liggett C.M., Haas B.J., Inman J.M., Kent R.,
RA   Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M.,
RA   Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R.,
RA   Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R.,
RA   Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX54/DBP10
CC       subfamily. {ECO:0000305}.
DR   EMBL; DS027698; EAW16333.1; -; Genomic_DNA.
DR   RefSeq; XP_001258230.1; XM_001258229.1.
DR   SMR; A1DNG2; -.
DR   STRING; 36630.CADNFIAP00004384; -.
DR   EnsemblFungi; EAW16333; EAW16333; NFIA_056820.
DR   GeneID; 4584745; -.
DR   KEGG; nfi:NFIA_056820; -.
DR   EuPathDB; FungiDB:NFIA_056820; -.
DR   HOGENOM; HOG000246455; -.
DR   KO; K14808; -.
DR   OMA; CVEMDLK; -.
DR   OrthoDB; 268859at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR012541; DBP10_C.
DR   InterPro; IPR033517; DDX54/DBP10.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   PANTHER; PTHR24031:SF292; PTHR24031:SF292; 1.
DR   Pfam; PF08147; DBP10CT; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM01123; DBP10CT; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    934       ATP-dependent RNA helicase dbp10.
FT                                /FTId=PRO_0000281716.
FT   DOMAIN      121    293       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      361    515       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     134    141       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        90    118       Q motif.
FT   MOTIF       241    244       DEAD box.
SQ   SEQUENCE   934 AA;  103372 MW;  1241FDC5CF4FDF9C CRC64;
     MPHRAASPAM SENEFDITGA LFQNDSDSDN EQPSAKSKRQ PPKKVPSQAL DFLGDVNEDD
     DDDEAFIAEQ QTSANRKASN LKGRTVKKGG GFQAMGLSAN LLKAIARKGF SVPTPIQRKT
     IPVIMDDQDV VGMARTGSGK TAAFVIPMIE KLKSHSTKVG ARGLILSPSR ELALQTLKVV
     KELGRGTDLK SVLLVGGDSL EEQFAMMAGN PDIVIATPGR FLHLKVEMNL DLSSIRYVVF
     DEADRLFEMG FAAQLTEILH GLPANRQTLL FSATLPKSLV EFARAGLQEP TLVRLDTESK
     ISPDLQNAFF SVKSSEKEGA LLYILQEVIK MPTGPTEVSQ QRKEEDASAK NWKNKKRKRA
     EMEKAVNMRE SPTKHSTIVF AATKHHVDYL YSLLSEAGFA VSYVYGSLDQ TARKIQVQNF
     RTGMTNILVV TDVAARGIDI PILANVINYD FPSQPKIFIH RVGRTARAGR KGWSYSLVRD
     ADAPYLLDLQ LFLGRRLVVG REFGDQVNFA EDVVTGSLPR DGLSQSCEWV TKVLDDNADL
     AAQRTVAAKG EKLYMRTRNS ASLESAKRSK QVVSSDNWTS IHPLFQDETS NLEAEREKML
     ARIGGYRPPE TIFEVNNRRM GKHENVDALD TIKRVRTTLE SKKKRAQANE KSEFLEDASD
     DEKAANEAGE NENEGAFSDE DDDVPTGVAD NMSMASDSEL EVTFSSYSQS KENKAKKASA
     ASFQNPEYFM SYTPNNNSLV EDRAYGVHSG TNSNFAQASR SATMDLAGDD GGRGFGEART
     LMRWDKRHKK YVARQNDEDG SKGTRLVRGE SGAKIAASFR SGRFDAWKRG NRLGRLPRVG
     EAEAPNLTAG LNAAISGKRF RHRKEQAPKR ADPLRGDYEK MKKKAELAKE RAMSKAGGAA
     PRGKSELKNT DDIRIARKLK QKRREKNARP SRKK
//
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