ID A1DNT2_NEOFI Unreviewed; 2700 AA.
AC A1DNT2;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Nonribosomal peptide synthase, putative {ECO:0000313|EMBL:EAW16453.1};
GN ORFNames=NFIA_058030 {ECO:0000313|EMBL:EAW16453.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW16453.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; DS027698; EAW16453.1; -; Genomic_DNA.
DR RefSeq; XP_001258350.1; XM_001258349.1.
DR STRING; 331117.A1DNT2; -.
DR EnsemblFungi; EAW16453; EAW16453; NFIA_058030.
DR GeneID; 4584866; -.
DR KEGG; nfi:NFIA_058030; -.
DR VEuPathDB; FungiDB:NFIA_058030; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_4_1; -.
DR OMA; ERSAWAI; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 2.
DR CDD; cd19542; CT_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702}.
FT DOMAIN 637..713
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2161..2237
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2232..2264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2700 AA; 297931 MW; A1621C0606A42F26 CRC64;
MAVLPAVQDS GDFGLQAGKH KYAIELVAEI GRDSIHLRLK YQDAFLSEKQ AHDVASTTKR
AIILCLQSTL EDTVGNANMI SERNKADLAS WHSGTFPLAT GFVHEVVRQR CFTDAAALAI
CAWDGELSYA ELDDLSDRLA VQLVEKGARP GVFVPVCFEK SKWAIVASLG VLKAGAAFVP
LDPSTPKERL ENVLRHVEAE FVLASCDHAN LFTATMMHCI VLSDVTIKQF PKPNMSISIP
LRGSDPAYVL FTSGSTGTPK ACLVDHSAFA GVSTHGVGMR MGPNSRVYQF ASHAFGMALI
DIYCALTLGA TVCVPSEAER TGSLAQSMTR MQTTWAILTP SIIQSICPDD LPHLQTLVTA
GEPLPRELMS LWAQRVHLVQ GYGLTEWAGI CAASEPLSPA DSPGNVGRLP TSRMWLVDPE
DPSRLVPVGA VGEMLLEGPC LAREYLKQPD ETSMSFISPP SWRFEYPGPF PNRLYRSGDL
MRYCDDGTCI YVGRKGTQVK IRGQRVELAE VEYNVRKSFP TTQNVIAELI VPRDDERPRL
TVFLLLQSTN PLPANPDQHD SFLAPPSEAF RAYAETVRAA LAAVLPRYMV PDLYIPLTRV
PLTPTGKRSR RDLRRIGSEK TLAELTSYIH VQQVALMPRS SQEILLQGIF AQVLKRDPST
ISVDDSFFHI GGDSIAGMQV SALCRKKGIN ISMQDLFRYR TIAALAPHVP VVDGMLVCDD
AAIDNISPKN ETMTQSYDHE TFALSIPQEM FFASCGCVPH QASQRRVMRL TRLFDAETVR
NAVVQLARWH PMLRARFTQS QTDEGTSKWQ QRIAQHSPTV FAFLTIHVSS TRDIPHIVAE
MQSSLHIEQG PIFTAALIYL ASEQYVALVA HCLVVDEVSW AILSRDLDAM LQGQSPAVEP
KTALSYERWC QSQQSRDRKG LLALVQAQRG EVPRGENSRR VSQMHFTLDK QVSAALVGNC
NDVFRTVPID IFHAALLVSY IRSFANATVP VILLERSDRQ IQTKEASQTV GWLSKINQVS
IDIDNEIDIV EAVRRAKDAR LCTEATTLPR VAAEEDIEDR TVKPLTVLFR HDPHELYTPG
QEGAVMLDRQ LSIEKDTAIQ VAACQPLASV DITVSCVQGC VQFTLQYQHQ AMAFPEVQRW
MQHYEQTLRD AVTQLTSMQT GYTLSDIALP SATYGNLQEV LRCSPMQQGI LLSQARNPEF
YRVQSFWKAH PPSNLPPGML LARFRTAWNK VIARHAILRT IMVESRVHPG SFDQVVLKEA
PPRIDGICLP RGDPIPVLRE RSRLCDLPTD MPAHHLTICI TTKEVYLGLT ISHALIDAQS
INIIMRDVGI AYDDKLPPQA PSYGKYIHYI QQLDLERSIT YWTQYLDGVN PSLLPSLDYR
RQVGEQQAPE LKSLSLEVEA APRLQQVCSK HGITISNLFQ LAWGLTLHCY TGLDDICFGY
LAAGRDIPLE ELDDAVGPYV NMLICRIQLA GSETLSQLLQ KNLTDFIDSS SSQHTPLGRI
LQSLSLSGPL FNTIISMRPP SHEVQKTSSL AIKPVWELDP TEFDLAINVD VSCDSVQVTM
NYWSTTCSDE QAANLASTLH RSLSSILETP HLTPAQLDLF SDDCYAQLQE LNAQSPERVE
DSATDLIASH IRSQPGAAAV CAWDGKFTYG ELGCLALQLA TQLAAQGAGP EVFVPILFKK
SRWAIVAILA VMQAGAAFVL LDPSHPIARL REICQQVHPP IVLCSVEHQE AAAELGDHLL
VLGDGIEAPW HTSSNKLGPL EPSQPSHALY AVFTSGTTGK PKGVVVEHAT FCSSAMAHGT
LFALRPSSRV LQFSSFAFDV SICEILTTLC FGGCVCVPSE DERLNDLAGA ISRLGANTAH
FTASVLRLLL PEQVPSLEMV VATGEAMSAA DVDQWANHVR LMCAYGPAEC CIYTHVQSQI
DRQADPRNIG YPTTGLAWLV DPKDHDRLAP LGSAGELVIE GPLVARGYLN HAGEPGEGFI
SEPRWRSRFS AGRHGAFYKT GDLARYGPKG SLRFIGRKDT QVKINGQRLE LAEVEYNLQQ
AVSVVSDRPL DVLVDIVSFG NLASDPTLTA FVASRMMPCD YATVSMADLA KEVSSLVPSL
RAHLHKLLPQ YMIPRMYITL DKFPLGKTGK ADRRRLREEA CKACRKGVHA EIPGTVTVKR
PPHNDAERKI QALVSRILGL PVNQVGLDDN FFLLGGDSMA AMKLVAAARS VGMMLSVKGV
LQQPRLVDLV QGQGQHLQLP GSGDEGAAQP CHPLPGSESN EVGDSMRDTI ASQMVFDASL
IQDVLPTTEF QAETVCTWPA TYFLITMHGC LDPRRLRVAT QMLLDRHEIL RTVFVRQETT
DHIVQVVLQP IPVPFFEFPC DSEDLSSACE LVCSMDSARG LPLGYLATQF TLFSQSANPK
YHILAVRLSH AQYDGYCMPL LYRDLARLYG DDTHPLPPVT QYAAYIRHLT RAEKSKARQF
WSHTLYASRV PTRLDELSLG APAESLMPGS LIELTTNMAM PTPHNGITVA SLMKSAAALI
LMSLCQTTDV VFCQVVSGRN VPLPGIETIV GVCANIVPVR VRARPRCTVQ SFLGAVQEQH
IEALDHEFLG LQEIRRYCTE WPMVSPFGCL IQHQSLDLSP EFSLSAKVEC TTRVFGGAFE
RSYLHLVTIP RDNQLTVQLF APPGLLDEPH CQRLLDRFCE TALWLSSHPD RMVDEWDASI
//