ID A1DP11_NEOFI Unreviewed; 925 AA.
AC A1DP11;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Vacuole-associated enzyme activator complex component (Vac14), putative {ECO:0000313|EMBL:EAW16532.1};
GN ORFNames=NFIA_058830 {ECO:0000313|EMBL:EAW16532.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW16532.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the VAC14 family.
CC {ECO:0000256|ARBA:ARBA00010225}.
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DR EMBL; DS027698; EAW16532.1; -; Genomic_DNA.
DR RefSeq; XP_001258429.1; XM_001258428.1.
DR AlphaFoldDB; A1DP11; -.
DR STRING; 331117.A1DP11; -.
DR EnsemblFungi; EAW16532; EAW16532; NFIA_058830.
DR GeneID; 4584945; -.
DR KEGG; nfi:NFIA_058830; -.
DR VEuPathDB; FungiDB:NFIA_058830; -.
DR eggNOG; KOG0212; Eukaryota.
DR HOGENOM; CLU_007740_0_0_1; -.
DR OMA; CYQHVSE; -.
DR OrthoDB; 5481081at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR GO; GO:0070772; C:PAS complex; IEA:EnsemblFungi.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:EnsemblFungi.
DR GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0042327; P:positive regulation of phosphorylation; IEA:EnsemblFungi.
DR GO; GO:1903778; P:protein localization to vacuolar membrane; IEA:EnsemblFungi.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR026825; Vac14.
DR InterPro; IPR021841; VAC14_Fig4p-bd.
DR PANTHER; PTHR16023:SF0; PROTEIN VAC14 HOMOLOG; 1.
DR PANTHER; PTHR16023; TAX1 BINDING PROTEIN-RELATED; 1.
DR Pfam; PF12755; Vac14_Fab1_bd; 1.
DR Pfam; PF11916; Vac14_Fig4_bd; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 86..121
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 593..770
FT /note="Vacuolar protein 14 C-terminal Fig4-binding"
FT /evidence="ECO:0000259|Pfam:PF11916"
FT REGION 277..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 925 AA; 102812 MW; 891E08DB2E611A09 CRC64;
MDHSIQRLLN DKLYDRRKQG ALELEKVVRN AVFRGDHEEI QKIVDQLCHD YAYAVHQPHA
RNGGLIGLAA ASIALGSGVA PYLKEIVPPV LACFSDQDAR VRYYACESMY NIAKVAKGEV
LLFFNEIFDA LSKLASDSEL SVKNGAELLD RLVKDIVSES AASYISVLQL SEKHTADPDA
QEEVELPTAF SLAKFIPLLK ERIHVISPST RTFLVSWLTL LDTIPDLELV SYLPEFLGGL
IEFLGDPNRD VNVTTQALLD RFLSEIKRIA RLKKGIEESR KEQGSDNRQS AASDSVSTTT
DHTVAVDTER NENAIEDSES GSDLEENDLQ ADGDWIPGQD VHIDYPKILD ILVGFVDTSF
DEEMQLTALR WIDSFFEISP EDILPFVPRL LTQVLPAMSS GSDQVRQAAN RVNTSLLEYI
VSLSEDSTEA RQGPPSRPIS TASKELVERR ASTPSGRQSV ETSTSESKKQ ASQQELSNEQ
TPRSSLISTP IPPADLDYAA AVNSLTLQFL NENEATRVAA LSWLIMLHRK APKKVVAFND
GTFPALLKTL SDPAEAVVTK DLQLLSQISR NSDDSYFTSF MVNLLQLFST DRHLLEVRGN
LIIRQLCMNL SPERIYRTLA DCLEKEEDIE FASIMVQNLN NNLITAPELS DLRKRLRNLD
SKEGQMFFVA LFRSWCHNAV STFSLCLLAQ AYEQAYNLLQ VFAELEMTVN MLIQIDKLVQ
LLESPVFTYL RLQLLEPERY PYLYKCLYGV LMLLPQSSAF AALKNRLNSV SNIGLLHTGP
RLTSMVSSSS SGYERATGSR LKNREENTIR WVELLDKFKS VQEKARRAQR ASQRQFDQDG
STAGLRNPSL TAALSAAATA DRGKERGLPD TPRGGRPDMG SSGGRNSPGD SGTPNRGSLL
SGTQRNKSGL PNLGRLGIGS RRSKR
//
