ID MUTS_YERE8 Reviewed; 851 AA.
AC A1JJU1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=YE0776;
OS Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS 8081).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=393305;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 13174 / 8081;
RX PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA Prentice M.B.;
RT "The complete genome sequence and comparative genome analysis of the high
RT pathogenicity Yersinia enterocolitica strain 8081.";
RL PLoS Genet. 2:2039-2051(2006).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; AM286415; CAL10878.1; -; Genomic_DNA.
DR RefSeq; WP_011815614.1; NC_008800.1.
DR RefSeq; YP_001005117.1; NC_008800.1.
DR AlphaFoldDB; A1JJU1; -.
DR SMR; A1JJU1; -.
DR KEGG; yen:YE0776; -.
DR PATRIC; fig|393305.7.peg.869; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_6; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000000642; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..851
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000008117"
FT BINDING 614..621
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 851 AA; 94754 MW; 874B58C9469726FE CRC64;
MNNTDKLDSH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YSDAKRASQL LDISLTKRGA
SAGEPIPMAG VPYHSIENYL AKLVQLGESA AICEQIGDPA TSKGPVERKV VRIVTPGTVS
DEALLQERQD NLLAAIWQDA RGFGYATLDI SSGRFRVAEP ADLETMAAEL QRTNPAELLY
PENFEQMSLI EHRHGLRRRP LWEFELETAK QQLNLQFGTR DLIGFGVEQA HQALRAAGCL
LQYVKDTQRT SLPHIRGLTM ERQQDGIVMD AATRRNLELT QNLSGGTENT LAAILDCTVT
AMGSRMLKRW LHMPIRDTKV LTDRQQAIGG LQDITAELQT PLRQVGDLER ILARLALRTA
RPRDLARMRH AFQQLPEIHR LLQPVNVPHI QNLLSQVGQF DELQDLLERA IVETPPVLVR
DGGVIASGYN AELDEWRALA DGATDYLDRL EIREREKLGL DTLKVGFNGV HGYYIQVSRG
QSHLVPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKGKA LAIEKGLYEE IFDLLLPHLP
ELQTSANALA ELDVLANLAE RAETLNYNCP VLSDKPGIKI TGGRHPVVEQ VLSEPFISNP
LTLSPQRRML IITGPNMGGK STYMRQTALI VLLAHMGSYV PADQATIGPV DRIFTRVGAA
DDLASGRSTF MVEMTETANI LHNATEQSLV LMDEIGRGTS TYDGLSLAWA CAENLASRIK
AMTLFATHYF ELTTLPEKME GVVNVHLDAL EHGETIAFMH SVQDGAASKS YGLAVAALAG
VPRDVIKRAR QKLKELESLS NNAAASKIDG SQLTLLNEEV SPAVEALEAL DPDSLSPRQA
LEWIYRLKNM V
//
