ID A1K2D8_AZOSB Unreviewed; 706 AA.
AC A1K2D8;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Ornithine--oxo-acid aminotransferase {ECO:0000256|ARBA:ARBA00030587};
DE EC=2.6.1.13 {ECO:0000256|ARBA:ARBA00012924};
DE EC=3.5.3.1 {ECO:0000256|ARBA:ARBA00012168};
GN OrderedLocusNames=azo0376 {ECO:0000313|EMBL:CAL92993.1};
OS Azoarcus sp. (strain BH72).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Azoarcus.
OX NCBI_TaxID=418699 {ECO:0000313|EMBL:CAL92993.1, ECO:0000313|Proteomes:UP000002588};
RN [1] {ECO:0000313|EMBL:CAL92993.1, ECO:0000313|Proteomes:UP000002588}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BH72 {ECO:0000313|EMBL:CAL92993.1,
RC ECO:0000313|Proteomes:UP000002588};
RX PubMed=17057704; DOI=10.1038/nbt1243;
RA Krause A., Ramakumar A., Bartels D., Battistoni F., Bekel T., Boch J.,
RA Boehm M., Friedrich F., Hurek T., Krause L., Linke B., McHardy A.C.,
RA Sarkar A., Schneiker S., Syed A.A., Thauer R., Vorhoelter F.-J.,
RA Weidner S., Puehler A., Reinhold-Hurek B., Kaiser O., Goesmann A.;
RT "Complete genome of the mutualistic, N2-fixing grass endophyte Azoarcus sp.
RT strain BH72.";
RL Nat. Biotechnol. 24:1385-1391(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-arginine = L-ornithine + urea; Xref=Rhea:RHEA:20569,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:46911; EC=3.5.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000227};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate
CC 5-semialdehyde from L-ornithine: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004998}.
CC -!- PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-
CC arginine: step 1/1. {ECO:0000256|ARBA:ARBA00005098}.
CC -!- SIMILARITY: Belongs to the arginase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00742}.
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DR EMBL; AM406670; CAL92993.1; -; Genomic_DNA.
DR RefSeq; WP_011764111.1; NC_008702.1.
DR AlphaFoldDB; A1K2D8; -.
DR STRING; 62928.azo0376; -.
DR KEGG; azo:azo0376; -.
DR eggNOG; COG0010; Bacteria.
DR eggNOG; COG4992; Bacteria.
DR HOGENOM; CLU_023563_0_0_4; -.
DR UniPathway; UPA00098; UER00358.
DR UniPathway; UPA00158; UER00270.
DR Proteomes; UP000002588; Chromosome.
DR GO; GO:0004053; F:arginase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004587; F:ornithine aminotransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0000050; P:urea cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd09989; Arginase; 1.
DR CDD; cd00610; OAT_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 3.40.800.10; Ureohydrolase domain; 1.
DR InterPro; IPR005814; Aminotrans_3.
DR InterPro; IPR049704; Aminotrans_3_PPA_site.
DR InterPro; IPR014033; Arginase.
DR InterPro; IPR010164; Orn_aminotrans.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR006035; Ureohydrolase.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR InterPro; IPR020855; Ureohydrolase_Mn_BS.
DR NCBIfam; TIGR01885; Orn_aminotrans; 1.
DR PANTHER; PTHR11986; AMINOTRANSFERASE CLASS III; 1.
DR PANTHER; PTHR11986:SF18; ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL; 1.
DR Pfam; PF00202; Aminotran_3; 1.
DR Pfam; PF00491; Arginase; 1.
DR PRINTS; PR00116; ARGINASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
DR PROSITE; PS01053; ARGINASE_1; 1.
DR PROSITE; PS51409; ARGINASE_2; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000256|ARBA:ARBA00022576};
KW Arginine metabolism {ECO:0000256|ARBA:ARBA00022503};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000002588};
KW Transferase {ECO:0000256|ARBA:ARBA00022576}.
SQ SEQUENCE 706 AA; 75538 MW; 9D96D9E3E1F0FD24 CRC64;
MNVPTPLPSG PHDRVHIVGA AFALGAPHGG SADGPEALRH AMLPERLRTT GITGTWLEPL
RPLRTPPPDA PMEERLAAVG EYCARLAEQI AGLPEDGFPL VLGGDHAVAI GTWRGVARRQ
GGAPGLIWID AHLDSHTDQS TWSGNIHGMP LAALLGEGAP ALTAIPGPRL DPARVCIIGA
RDWEPAERER LDRLGVRVFD IAEVRERGLP TVFCEALTIA RSGHGRDGGF GVTLDLDALD
PLAVPAVTCP TPDGIDPQQL VDVFHTLRSC GDFVGLEIVE YRPDLDPDGH SAALTARLVA
AALGPATYWL REKERRFGAT NYAPMPVVFH RGEGVWLWDV EGTRYLDMMS AYSAVSFGHA
NPRLLRALQD QAQLLTLTSR SFSNDRLPLL LERLCSLLGF ERALPVNTGL EAVETALKAA
RKWAYIVKGV PPDRAEIIAC EGNFHGRSIT IVGLSSKEQY RDGFGPFPPG LRRVPFGDPT
ALEAAITPHT AAFLVEPIQG EGGIIVPPPG YLAHCAEICR RHNVLLIADE VQTGLGRTGR
LLACDHDGVR PDGLILGKAL GGGLLPVSAF LADREVMDVF RPGDHGSTFG GNPLGAAVAL
EVLDLLAETR PWEAAERLGR RLRAELEAAE LPCVREVRGR GLLIGVALDP VKAPAQLVAE
LLLARGIATR DTNGNVIRLA PPLTIDEGTL DRAAAIIIDT LNPLGR
//
