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Database: UniProt
Entry: A1KWM6
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ID   MUTS_NEIMF              Reviewed;         864 AA.
AC   A1KWM6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NMC2138;
OS   Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM
OS   15464 / FAM18).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=272831;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700532 / DSM 15464 / FAM18;
RX   PubMed=17305430; DOI=10.1371/journal.pgen.0030023;
RA   Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C.,
RA   Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K.,
RA   Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S.,
RA   Quail M.A., Achtman M., Barrell B.G., Saunders N.J., Parkhill J.;
RT   "Meningococcal genetic variation mechanisms viewed through comparative
RT   analysis of serogroup C strain FAM18.";
RL   PLoS Genet. 3:230-240(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM421808; CAM11286.1; -; Genomic_DNA.
DR   RefSeq; WP_002215177.1; NC_008767.1.
DR   AlphaFoldDB; A1KWM6; -.
DR   SMR; A1KWM6; -.
DR   KEGG; nmc:NMC2138; -.
DR   HOGENOM; CLU_002472_4_1_4; -.
DR   Proteomes; UP000002286; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd03284; ABC_MutS1; 1.
DR   Gene3D; 1.10.1420.10; -; 2.
DR   Gene3D; 6.10.140.430; -; 1.
DR   Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR   Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR01070; mutS1; 1.
DR   PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR   SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..864
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008077"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   864 AA;  95278 MW;  203B7D097994BAB2 CRC64;
     MSKSAVSPMM QQYLGIKAQH TDKLVFYRMG DFYEMFFDDA VEAAKLLDIT LTTRGQVDGE
     PVKMAGVPFH AAEQYLARLV KLGKSVAICE QVGEVGAGKG PVERKVVRIV TPGTLTDSAL
     LEDKETNRIV AVSPDKKYIG LAWASLQSGE FKTKLTTVDK LDDELARLQA AEILLPDSKN
     APQLQTASGV TRLNAWQFAA DAGEKLLTEY FGCQDLRGFG LDGKEHAVAI GAAGALLNYI
     RLTQNLMPQH LDGLSLETDS QYIGMDAATR RNLEITQTLS GKKSPTLMST LDLCATHMGS
     RLLALWLHHP LRNRAHIRAR QEAVAALESQ YKPLQCRLKN IADIERIAAR IAVGNARPRD
     LASLRDSLFE LAQIDLSANG SSLLETLKAV FPENLSTAEQ LRQAILPEPS VWLKDGNVIN
     HGFHPELDEL RRIQNHGDEF LLDLEAKERE RTGLSTLKVE FNRVHGFYIE LSKTQAEQAP
     ADYQRRQTLK NAERFITPEL KAFEDKVLTA QEQALALEKQ LFDGVLKNLQ TALPQLQKAA
     KAAAALDVLS TFSALAKERN FVRPEFADYP VIHIENGRHP VVEQQVRHFT ANHTDLDHKH
     RLMLLTGPNM GGKSTYMRQV ALIVLLAHTG CFVPADAATI GPIDQIFTRI GASDDLASNR
     STFMVEMSET AYILHHATEQ SLVLMDEVGR GTSTFDGLAL AHAVAEHLLQ KNKSFSLFAT
     HYFELTYLPE AHAAAVNMHL SALEQGQDIV FLHQIQPGPA GKSYGIAVAK LAGLPVRALK
     SAQKHLNGLE NQAAANRPQL DIFSTMPSEK GDEPNVGNFV DKAEEKHFEG ILAAALEKLD
     PDSLTPREAL SELYRLKDLC KSVS
//
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