ID A1L2A9_DANRE Unreviewed; 328 AA.
AC A1L2A9; B2GPI5; F6NIV9;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE SubName: Full=Patatin-like phospholipase domain containing 7a {ECO:0000313|Ensembl:ENSDARP00000086080, ECO:0000313|RefSeq:NP_001074124.1};
DE SubName: Full=Zgc:158748 {ECO:0000313|EMBL:AAI29428.1, ECO:0000313|EMBL:AAI64358.1};
GN Name=pnpla7a {ECO:0000313|RefSeq:NP_001074124.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070112-1812};
GN Synonyms=clic3 {ECO:0000313|Ensembl:ENSDARP00000086080}, zgc:158748
GN {ECO:0000313|EMBL:AAI64358.1, ECO:0000313|RefSeq:NP_001074124.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI64358.1};
RN [1] {ECO:0000313|EMBL:AAI64358.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAI29428.1}, and PCR rescue
RC {ECO:0000313|EMBL:AAI64358.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000086080}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000086080};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000086080, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000086080};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_001074124.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [5] {ECO:0000313|RefSeq:NP_001074124.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25142379; DOI=10.1007/s12015-014-9523-2;
RA Liu R., Li M., Li Z., Hong N., Xu H., Hong Y.;
RT "Medaka Oct4 is essential for pluripotency in blastula formation and ES
RT cell derivation.";
RL Stem. Cell. Rev. Rep. 11:11-23(2015).
RN [6] {ECO:0000313|RefSeq:NP_001074124.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [7] {ECO:0000313|RefSeq:NP_001074124.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; FP089537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; FP089550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC129427; AAI29428.1; -; mRNA.
DR EMBL; BC164358; AAI64358.1; -; mRNA.
DR RefSeq; NP_001074124.1; NM_001080655.1.
DR STRING; 7955.ENSDARP00000086080; -.
DR Ensembl; ENSDART00000091647; ENSDARP00000086080; ENSDARG00000062986.
DR Ensembl; ENSDART00000091647.6; ENSDARP00000086080.4; ENSDARG00000062986.8.
DR GeneID; 791173; -.
DR KEGG; dre:791173; -.
DR AGR; ZFIN:ZDB-GENE-070112-1812; -.
DR CTD; 791173; -.
DR ZFIN; ZDB-GENE-010507-2; clic3.
DR ZFIN; ZDB-GENE-070112-1812; pnpla7a.
DR HOGENOM; CLU_875882_0_0_1; -.
DR OrthoDB; 4489242at2759; -.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000062986; Expressed in blastula and 21 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004622; F:lysophospholipase activity; IBA:GO_Central.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR Pfam; PF00027; cNMP_binding; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A1L2A9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 168..295
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 328 AA; 36860 MW; 0F619E2D5DEE38B4 CRC64;
MGEEDEGLCL YPAIGSDIRS RLQQFVEERM QTTMLTGVLI GAAVAVCLIG ITVLLLYRRY
KHASQEAGVP RYRFRKRDKV LFYGRKIMRK VQTLSSTPTS TLVSKQRSRK RPKVLSIARR
ILRIRKEPPT LQPKEPPPSL LEADLTEFDV QNSNLPSEVL YMLKNVRVLG HFEKPLFLEL
CRHMVFVELQ EGEGLFKPGD DDDSIYVVQD GRLELCILEI DGTELVVKDV LPGDSVHSLL
SILDIITGYP APYKTVSARA AVRSTILRLP ASAFQSVFEK YPETLVRVIQ VLNSAVAVCI
SVTSALLNIC LSHCVTTGHI LHLFFPLK
//
