ID A1S127_THEPD Unreviewed; 451 AA.
AC A1S127;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=Tpen_1762 {ECO:0000313|EMBL:ABL79157.1};
OS Thermofilum pendens (strain DSM 2475 / Hrk 5).
OC Archaea; Thermoproteota; Thermoprotei; Thermofilales; Thermofilaceae;
OC Thermofilum.
OX NCBI_TaxID=368408 {ECO:0000313|EMBL:ABL79157.1, ECO:0000313|Proteomes:UP000000641};
RN [1] {ECO:0000313|Proteomes:UP000000641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2475 / Hrk 5 {ECO:0000313|Proteomes:UP000000641};
RX PubMed=18263724; DOI=10.1128/JB.01949-07;
RA Anderson I., Rodriguez J., Susanti D., Porat I., Reich C., Ulrich L.E.,
RA Elkins J.G., Mavromatis K., Lykidis A., Kim E., Thompson L.S., Nolan M.,
RA Land M., Copeland A., Lapidus A., Lucas S., Detter C., Zhulin I.B.,
RA Olsen G.J., Whitman W., Mukhopadhyay B., Bristow J., Kyrpides N.;
RT "Genome sequence of Thermofilum pendens reveals an exceptional loss of
RT biosynthetic pathways without genome reduction.";
RL J. Bacteriol. 190:2957-2965(2008).
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; CP000505; ABL79157.1; -; Genomic_DNA.
DR RefSeq; WP_011753422.1; NC_008698.1.
DR AlphaFoldDB; A1S127; -.
DR STRING; 368408.Tpen_1762; -.
DR EnsemblBacteria; ABL79157; ABL79157; Tpen_1762.
DR GeneID; 4601960; -.
DR KEGG; tpe:Tpen_1762; -.
DR eggNOG; arCOG00874; Archaea.
DR HOGENOM; CLU_008213_6_0_2; -.
DR OrthoDB; 11644at2157; -.
DR Proteomes; UP000000641; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd17926; DEXHc_RE; 1.
DR Gene3D; 3.40.1170.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR040699; XPB_DRD.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF18458; XPB_DRD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:ABL79157.1};
KW Helicase {ECO:0000313|EMBL:ABL79157.1};
KW Hydrolase {ECO:0000313|EMBL:ABL79157.1};
KW Nucleotide-binding {ECO:0000313|EMBL:ABL79157.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000641}.
FT DOMAIN 82..226
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 319..451
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 451 AA; 51097 MW; F9D591E3CA410794 CRC64;
MLKLEWSAGT ILLRGSPPPS VAPYFRFDPR VKGYRALAIQ YRWIVEALRE AGVEFEDDVL
HPPQCKLQAR EVQLRDYQEE ALERWMAGRR GVVVLPTGAG KTMVALAAIA RLACPTLIVV
PTLELMDQWE EGVRRHLGVA PGRYGGGEKE VGCVTVATYD SAYVNAEFLG DKFELLVFDE
VHHLPSPGYR QVAELSAAPW RMGLTATPER EDGLHELLPY LVGPVVYRRG VGEMAGKWLA
EFDVVRVYAE MSPEEREEYE RLTRTYRSFL RKRGLRIRGP RDFERLAALS VKDPEAREAL
LAWYRARRIA LHASSKMEVL EELLARHRGD KVLIFAEHGD VVRRISSRFL VPEITYRTPE
EERRAVMSAF RKGLVRAIVT SKVLEEGVDV PDANVAVILS GTASRREFVQ RLGRVLRPRE
GKRAVVYEVV TSGTKEVEIS RKRRKALKGG Q
//
