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Database: UniProt
Entry: A1SDC7_NOCSJ
LinkDB: A1SDC7_NOCSJ
Original site: A1SDC7_NOCSJ 
ID   A1SDC7_NOCSJ            Unreviewed;       579 AA.
AC   A1SDC7;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   28-FEB-2018, entry version 78.
DE   RecName: Full=Malto-oligosyltrehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
DE            Short=MTHase {ECO:0000256|PIRNR:PIRNR006337};
DE            EC=3.2.1.141 {ECO:0000256|PIRNR:PIRNR006337};
DE   AltName: Full=4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
DE   AltName: Full=Maltooligosyl trehalose trehalohydrolase {ECO:0000256|PIRNR:PIRNR006337};
GN   OrderedLocusNames=Noca_0267 {ECO:0000313|EMBL:ABL79812.1};
OS   Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC   Bacteria; Actinobacteria; Propionibacteriales; Nocardioidaceae;
OC   Nocardioides.
OX   NCBI_TaxID=196162 {ECO:0000313|EMBL:ABL79812.1, ECO:0000313|Proteomes:UP000000640};
RN   [1] {ECO:0000313|Proteomes:UP000000640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Thompson L.S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA   Mattes T., Gossett J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of (1->4)-alpha-D-glucosidic
CC       linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to
CC       yield trehalose and (1->4)-alpha-D-glucan.
CC       {ECO:0000256|PIRNR:PIRNR006337}.
CC   -!- PATHWAY: Glycan biosynthesis; trehalose biosynthesis.
CC       {ECO:0000256|PIRNR:PIRNR006337}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRSR:PIRSR006337-1}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
CC       {ECO:0000256|PIRNR:PIRNR006337, ECO:0000256|SAAS:SAAS00964676}.
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DR   EMBL; CP000509; ABL79812.1; -; Genomic_DNA.
DR   RefSeq; WP_011753763.1; NC_008699.1.
DR   ProteinModelPortal; A1SDC7; -.
DR   STRING; 196162.Noca_0267; -.
DR   CAZy; CBM48; Carbohydrate-Binding Module Family 48.
DR   CAZy; GH13; Glycoside Hydrolase Family 13.
DR   EnsemblBacteria; ABL79812; ABL79812; Noca_0267.
DR   KEGG; nca:Noca_0267; -.
DR   eggNOG; ENOG4105C9C; Bacteria.
DR   eggNOG; COG0296; LUCA.
DR   HOGENOM; HOG000155669; -.
DR   KO; K01236; -.
DR   OMA; FTPMLFM; -.
DR   OrthoDB; POG091H0CAL; -.
DR   BioCyc; NSP196162:GH4V-269-MONOMER; -.
DR   UniPathway; UPA00299; -.
DR   Proteomes; UP000000640; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0033942; F:4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005992; P:trehalose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR022567; DUF3459.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR012768; Trehalose_TreZ.
DR   Pfam; PF00128; Alpha-amylase; 2.
DR   Pfam; PF11941; DUF3459; 1.
DR   PIRSF; PIRSF006337; Trehalose_TreZ; 1.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   TIGRFAMs; TIGR02402; trehalose_TreZ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000640};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR006337,
KW   ECO:0000313|EMBL:ABL79812.1};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR006337,
KW   ECO:0000313|EMBL:ABL79812.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000640}.
FT   DOMAIN      103    448       Aamy. {ECO:0000259|SMART:SM00642}.
FT   ACT_SITE    248    248       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006337-1}.
FT   ACT_SITE    285    285       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006337-1}.
FT   SITE        381    381       Transition state stabilizer.
FT                                {ECO:0000256|PIRSR:PIRSR006337-3}.
SQ   SEQUENCE   579 AA;  63684 MW;  ACA6FE27DC5973B5 CRC64;
     MTHGPFDVWA PLPRRLRLAV AGETVAMRRG EGDWWTPAGP VPAGAELDYG YLVDDGEAPR
     PDPRSRRQPG GVHQLSRTFD PASYPWTDQA WTGRQLAGSV VYELHVGTFT PEGTFDAALE
     KLPHLREIGV DLVELMPVNA FNGTHNWGYD GVGWFAVHEG YGGPAGYQRF VDGCHAAGLG
     VIQDVVYNHL GPSGNYLPEL GPYLKQGANT WGDFLNLDGP GSDEVRRYIL DNVRMWLADY
     HVDGLRLDAV HALNDAGHQH LLEELAAEVA ALSAHQRRPL TLIAESDLND TRLVRPREAG
     GYGLDAQWSD DFHHAVHVAL TGETAGYYAD FEPLSALAKV CERGFFHDGT WSSFRGRDHG
     FPVDLRTMPT WRLVVCSQNH DQIGNRARGD RITEVLDDDQ LACAALLTLC GPFTPMLFMG
     EEWAASTPFQ FFTSHPEPDL GTATAEGRIA EFERMGWDPA VVPDPQDPAT FERSKLDWAE
     ATRGRHARML DVYRRLARLR REHEALTDPS FGSVRCTADE HTRVFTMRRG DLLVAVNFGD
     AAATVETAAA TLLFQTGAGL TLDAGRLSLP PHAGALVGP
//
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