ID A1T5A5_MYCVP Unreviewed; 522 AA.
AC A1T5A5;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=UmuC domain-containing protein {ECO:0000259|PROSITE:PS50173};
DE Flags: Precursor;
GN OrderedLocusNames=Mvan_1523 {ECO:0000313|EMBL:ABM12355.1};
OS Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 /
OS KCTC 9966 / NRRL B-24157 / PYR-1) (Mycobacterium vanbaalenii).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=350058 {ECO:0000313|EMBL:ABM12355.1, ECO:0000313|Proteomes:UP000009159};
RN [1] {ECO:0000313|EMBL:ABM12355.1, ECO:0000313|Proteomes:UP000009159}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 /
RC PYR-1 {ECO:0000313|Proteomes:UP000009159};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Anderson I.J., Miller C., Richardson P.;
RT "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; CP000511; ABM12355.1; -; Genomic_DNA.
DR RefSeq; WP_011778780.1; NZ_JACKSD010000111.1.
DR AlphaFoldDB; A1T5A5; -.
DR STRING; 350058.Mvan_1523; -.
DR KEGG; mva:Mvan_1523; -.
DR eggNOG; COG0389; Bacteria.
DR HOGENOM; CLU_026357_0_0_11; -.
DR Proteomes; UP000009159; Chromosome.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd03468; PolY_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR Pfam; PF00817; IMS; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009159};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..522
FT /note="UmuC domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039089678"
FT DOMAIN 29..153
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 522 AA; 56031 MW; B9299F2433523CEF CRC64;
MQSRVLALWC MDWPAVAAAA AADLPPTVPV AVTLANRVIA CSAAARAVGV RRGLRRRESQ
ARCPGLHVVT ADPARDARHF ENVTAAVDDL VPRAEVLRPG LLALSVRGAA RYFGSEQTAA
ERLVDAVAAV GAECQVGVAD QLPTAVFAAR AGRIIDAGED AAFLSGLSIR QLAAEPSLAP
APREALTDLL WRMGIRTIGQ FAELSRSDVA SRFGADAVAA HRIARGEPGR GPSGREPEAE
LDAVLNCDPP VDRVDAAAFA GRSLAGELHR SLEAAGVGCT RLAIHAVTAT GQELERVWRC
AEPLTEDATA DRVRWQLDGW LNRRNPQDRP AAPITVLRLR PVEVVSAEAL QLPLWGGVGE
EDRLRARRAL VRVQGLLGPE AVKVPVLSGG RGPAERITFT PLGDELVPQA DPGQPWPGRL
PEPSPTVLLD DPVELFDAEG NPVRVTGRGL FSTDPVRLHA PGRSGRLSWW AGPWPVDERW
WDAAPAKTGR TARAQVLLGA DPAQALLLCY RRRRWYLEGV YE
//
