ID A1U9F6_MYCSK Unreviewed; 362 AA.
AC A1U9F6;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Hydroxyneurosporene-O-methyltransferase {ECO:0000313|EMBL:ABL89464.1};
DE EC=2.1.1.- {ECO:0000313|EMBL:ABL89464.1};
GN OrderedLocusNames=Mkms_0247 {ECO:0000313|EMBL:ABL89464.1};
OS Mycobacterium sp. (strain KMS).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=189918 {ECO:0000313|EMBL:ABL89464.1};
RN [1] {ECO:0000313|EMBL:ABL89464.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KMS {ECO:0000313|EMBL:ABL89464.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D.,
RA Richardson P.;
RT "Complete sequence of chromosome of Mycobacterium sp. KMS.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP000518; ABL89464.1; -; Genomic_DNA.
DR AlphaFoldDB; A1U9F6; -.
DR STRING; 189918.Mkms_0247; -.
DR KEGG; mkm:Mkms_0247; -.
DR HOGENOM; CLU_005533_12_0_11; -.
DR OrthoDB; 4145676at2; -.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.287.1350; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:ABL89464.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:ABL89464.1}.
FT DOMAIN 136..343
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 272
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 362 AA; 38926 MW; 8690F8CD5FD2328B CRC64;
MATPKVPPVR LARAVERLRH VLDRAHQRSA PPSAVMLEKI LGAWISQGIT VAADLRVADA
LADGPLPIGE LARRVGANPD ALARLMRALI GEGVFTQRRD GRYALNALGR TLCTDATMSV
AGMARMIGHP AHREHWSQLL DAIRTGEATV PKLRGMPGFE YLSENRELGE IFNDAMTNLS
ETAVAPLTAA YDFRGFGTIV DVGGGHGRFL SAILAATPSA RGVLYDLPQV VEGATELLGS
HGVADRVEIV GGSFFDSIPA GADAYVAKNV IHDWPDADAL TILRNIRSAA GTGATLLLAE
FVIPDHHRAF IGNWTDMEML MATAARERTE AEYRKLYQQA GFRLTRVVPT VAPISLIEGK
AV
//
