ID A1UCI6_MYCSK Unreviewed; 387 AA.
AC A1UCI6;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) {ECO:0000256|ARBA:ARBA00038858};
DE EC=5.1.3.14 {ECO:0000256|ARBA:ARBA00038858};
GN OrderedLocusNames=Mkms_1332 {ECO:0000313|EMBL:ABL90544.1};
OS Mycobacterium sp. (strain KMS).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=189918 {ECO:0000313|EMBL:ABL90544.1};
RN [1] {ECO:0000313|EMBL:ABL90544.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KMS {ECO:0000313|EMBL:ABL90544.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D.,
RA Richardson P.;
RT "Complete sequence of chromosome of Mycobacterium sp. KMS.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:68623; EC=5.1.3.14;
CC Evidence={ECO:0000256|ARBA:ARBA00036080};
CC -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC {ECO:0000256|ARBA:ARBA00038209, ECO:0000256|RuleBase:RU003513}.
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DR EMBL; CP000518; ABL90544.1; -; Genomic_DNA.
DR AlphaFoldDB; A1UCI6; -.
DR STRING; 189918.Mkms_1332; -.
DR KEGG; mkm:Mkms_1332; -.
DR HOGENOM; CLU_041674_1_0_11; -.
DR OrthoDB; 9803238at2; -.
DR GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:UniProtKB-EC.
DR CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR InterPro; IPR029767; WecB-like.
DR NCBIfam; TIGR00236; wecB; 1.
DR PANTHER; PTHR43174; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR PANTHER; PTHR43174:SF2; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR Pfam; PF02350; Epimerase_2; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU003513}.
FT DOMAIN 29..371
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
SQ SEQUENCE 387 AA; 40790 MW; 7E7B6D8EE2088882 CRC64;
MGGVTEVHLV AGTRPEAIKL APLVPALRAQ GMTPVFVASG QHPTMVHQAL DAFGLEPDVT
LSIDRGSGSQ AELMAALTMK LEKHWQQRTP AAVVVQGDTT TVLAAAMVAF WAKLPIAHLE
AGLRSHDLAA PFPEEGNRKL VGQISRLHLA PTARARANLE REGTPSADIV VTGNTVIDAV
LGIAARGGPV TDSRVAAFVE RARAGASRLV LVTAHRRESW GEPLDRVLNA VALLLEKYSD
VEVVLPAHPN PAVAEQVRAV LGAHPRVLVT EPLAYPVLVG ALAASTLVLS DSGGIQEEAP
SFGVPVIVLR EVTERMEAVD AGCAILVGTD RDAVLGNACR LLDDPDERTA MVSKGNPFGD
GRAAERSAAA IAWMLGRTDG RPAEFRF
//
