ID   A1UM86_MYCSK            Unreviewed;      1299 AA.
AC   A1UM86;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 105.
DE   SubName: Full=Mur ligase, middle domain protein {ECO:0000313|EMBL:ABL93944.1};
GN   OrderedLocusNames=Mkms_4753 {ECO:0000313|EMBL:ABL93944.1};
OS   Mycobacterium sp. (strain KMS).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=189918 {ECO:0000313|EMBL:ABL93944.1};
RN   [1] {ECO:0000313|EMBL:ABL93944.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KMS {ECO:0000313|EMBL:ABL93944.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Mycobacterium sp. KMS.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000518; ABL93944.1; -; Genomic_DNA.
DR   STRING; 189918.Mkms_4753; -.
DR   KEGG; mkm:Mkms_4753; -.
DR   HOGENOM; CLU_261599_0_0_11; -.
DR   GO; GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.90.190.20; Mur ligase, C-terminal domain; 1.
DR   Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR   InterPro; IPR019079; Capsule_synth_CapA.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR036565; Mur-like_cat_sf.
DR   InterPro; IPR004101; Mur_ligase_C.
DR   InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR   InterPro; IPR013221; Mur_ligase_cen.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR43024; UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE; 1.
DR   PANTHER; PTHR43024:SF1; UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE; 1.
DR   Pfam; PF02875; Mur_ligase_C; 1.
DR   Pfam; PF08245; Mur_ligase_M; 1.
DR   Pfam; PF09587; PGA_cap; 1.
DR   SMART; SM00854; PGA_cap; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
DR   SUPFAM; SSF53244; MurD-like peptide ligases, peptide-binding domain; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:ABL93944.1}.
FT   DOMAIN          930..1190
FT                   /note="Capsule synthesis protein CapA"
FT                   /evidence="ECO:0000259|SMART:SM00854"
FT   REGION          907..927
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1299 AA;  142082 MW;  78DF26C1EA473525 CRC64;
     MENSADRSHD CEDRPDIGRF LARANPGESV ATAQPCDIRL TRADVDAAIA LGGRYLVSAQ
     REDGSFVYEV DWMTGEESAD DNVVRQAGAT WGVALLHRET REPDHRAAVD RSLRKWDTAV
     REIDGRRWLA DGEFRSGKLG AVALIGLSLL ERLAVPEGLD DPARMRASLD ALCRFVEDAR
     SPSGGFQKAF DTRTGNHSGA ADPYSSGEAL LLLARSGIEL GEPDRLERAL AWAEEDYHEF
     VVRPLADEPD PDVTKGYYQW GSMTWFAFAT AGHAPETWGR RLIEQALWMV DVHRTLSRKR
     NTGYAYEGIV PAWEWARRTG NEDTARKLAC VVHQGLRKLC AWQLGHPLAS SALRSAPEQF
     HGAVQNHARQ SALRIDVTQH QLHALMYARR FSVDAAEHLC ATDISAAPAV SVQTGNRNHK
     APSSDLNAHE LAEITQGVWE VMPPDGWTMK AVAFVKKRLE PQALVLPHCR TYRYGVDRDT
     VRGLNGNGYA LLADATPLAF PHGVPRLKVA SVRNALTNLA LATRASYPGR IVAVTGSAGK
     TSTCNMIEDL LQVFGVPKRP TKNFNTFDGV NGEVANLTNE AIAVIEVAAS FLSQRGGPRP
     NVLRPEVAMI TSIGEAHLEY FGSPQGVAEV KSNVFDLMSR GTAVIPRDAD TYDYMVQRAR
     AAGATTVSFG AHPSADAHLL SYSAADGVVE AEIFGERITY ELGALGRHFA RNSVGALGVV
     AALGLDWRRA AGALASSREV TGRGMTFDVG SASGRFTLID DAYNANPSSV RAAIEMLSER
     ATPPRGRRIA VLADMLELGP RSEEFHRALA EPLLGAAIDR VYLVGDQMRA LWDDLPSEIR
     GQYYPTVDGL QAALDREFAD GDVVLFKGSN GTELHKVVAH FKRATKRRSD APKDLARSED
     TGFVQPAGRR RLEVRARHPK SSQSGSRRTS LVFVGDLSMG DCYLKRPHLS VARHRLEENP
     WSFVELLAPL VQDKSLLVAN LETVLAERPA DPFRGMKKYQ GWDDPVRTLA VMQRLGVDAV
     SLANNHTMDF GVAPLRRTIA HLESTNIVPF GAGENEVQAA RPLSVSAPFG NVHIFAGYEF
     RTGYARKWNF YASGDAAGVN PLTGRATGSL IADIARTRTD DPASVIVVYP HWSGARNYQW
     ATDEMIGMNS EFLDAGADFV IGHGAHRMQE IVSGREGTTV FSLGNFVFNS PGRYAKFGSP
     TFSLVARLEI EDGDPVTGIG ADLHIYPIMS DNRETGFRPR PVRKSEAVQV YNILAGQSGA
     RFREDFDLEH GDRGWYIGRT IPLSMAGGQR RRDAVTSPA
//