ID A1XC24_BOVIN Unreviewed; 1050 AA.
AC A1XC24;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:ABC69205.1, ECO:0000313|Ensembl:ENSBTAP00000029890.4};
GN Name=TLR7 {ECO:0000313|EMBL:ABC69205.1,
GN ECO:0000313|Ensembl:ENSBTAP00000029890.4,
GN ECO:0000313|VGNC:VGNC:52836};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:ABC69205.1};
RN [1] {ECO:0000313|EMBL:ABQ52582.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18439678; DOI=10.1016/j.molimm.2008.02.028;
RA Zhu J., Lai K., Brownile R., Babiuk L.A., Mutwiri G.K.;
RT "Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand,
RT imiquimod.";
RL Mol. Immunol. 45:3238-3243(2008).
RN [2] {ECO:0000313|EMBL:ABC69205.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Kidney {ECO:0000313|EMBL:ABC69205.1};
RX PubMed=19568743; DOI=10.1007/s00251-009-0381-z;
RA Astakhova N.M., Perelygin A.A., Zharkikh A.A., Lear T.L., Coleman S.J.,
RA Macleod J.N., Brinton M.A.;
RT "Characterization of equine and other vertebrate TLR3, TLR7, and TLR8
RT genes.";
RL Immunogenetics 61:529-539(2009).
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000029890.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029890.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSBTAP00000029890.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029890.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-
CC like receptors) control host immune response against pathogens through
CC recognition of molecular patterns specific to microorganisms. TLR9 is a
CC nucleotide-sensing TLR which is activated by unmethylated cytidine-
CC phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. Upon CpG stimulation, induces B-cell
CC proliferation, activation, survival and antibody production.
CC {ECO:0000256|ARBA:ARBA00024895}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; DQ333225; ABC69205.1; -; mRNA.
DR EMBL; EF583900; ABQ52582.1; -; mRNA.
DR RefSeq; XP_005228543.1; XM_005228486.3.
DR RefSeq; XP_010820553.1; XM_010822251.2.
DR RefSeq; XP_015317288.1; XM_015461802.1.
DR PaxDb; 9913-ENSBTAP00000029890; -.
DR Ensembl; ENSBTAT00000029895.5; ENSBTAP00000029890.4; ENSBTAG00000022161.5.
DR Ensembl; ENSBTAT00000077162.1; ENSBTAP00000061744.1; ENSBTAG00000022161.5.
DR GeneID; 493686; -.
DR CTD; 51284; -.
DR VEuPathDB; HostDB:ENSBTAG00000022161; -.
DR VGNC; VGNC:52836; TLR7.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000159771; -.
DR HOGENOM; CLU_006000_2_0_1; -.
DR OMA; CNSKYLR; -.
DR OrthoDB; 5356114at2759; -.
DR TreeFam; TF325595; -.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000022161; Expressed in monocyte and 96 other cell types or tissues.
DR GO; GO:0032009; C:early phagosome; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0035197; F:siRNA binding; IEA:Ensembl.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0007254; P:JNK cascade; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0070305; P:response to cGMP; IEA:Ensembl.
DR GO; GO:0034154; P:toll-like receptor 7 signaling pathway; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 11.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ABC69205.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 890..1034
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1050 AA; 120883 MW; 75635C52A4936F5B CRC64;
MVFPMWTLKR QFPILFNMIL ISGLLGARWF PKTLPCDVTL DAPNTHVIVD CTDKHLTEIP
GGIPANATNL TLTINHIAGI SPASFHRLDH LVEIDFRCNC VPVRLGPKDN VCTKRLQIKP
NSFSKLTYLK SLYLDGNQLL EIPQDLPPSL QLLSLEANNI FLIMKENLTE LANLEILYLG
QNCYYRNPCN VSFTIEKDAF LNMRNLKLLS LKDNNISAVP TVLPSSLTEL YLYNNIITKI
QEDDFNNLSQ LQVLDLSGNC PRCYNVPFPC TPCENNSPLQ IDPNAFDALT ELQVLRLHSN
SLQHVPQRWF KNINKLKELD LSQNFLAKEI GDAKFLHLLH NLVNLDLSFN YDLQVYHAVI
NLSDAFSSLK KLKVLRIKGY VFKELNSLNL FPLHNLPNLE VLDLGTNFIK IANLSIFNQF
KTLKFIDLSV NKISPSGDSP EGGFCSNRRT SVEGHGPQVL ETLHYFRYDE YARSCRSKSK
EPPSFLPLNE DCYMYGQTLD LSRNNIFFIK PSDFQHLSFL KCLNLSGNSI SQTLNGSEFQ
PLVELKYLDF SNNRLDLLYS TAFEELHNLE VLDISSNSHY FQSEGITHML NFTKNLKVLR
KLMMNYNDIA TSTSRTMESE SLQILEFRGN HLDILWRDGD NRYLKFFKNL LNLEELDISE
NSLSFLPLGV FDSMPPNLKT LSLAKNGLKS FSWERLQSLK NLETLDLSFN QLKTVPERLS
NCSRSLKKLI LKNNQIRCLT KYFLQGAFQL RHLDLSSNKI QVIQKTSFPE NVLNNLNILF
LHHNRFLCNC DAVWFVWWVN HTEVTIPYLA TDVTCMGPGA HKGQSVVSLD LYTCELDLTN
FILFSLSISA VLSLMMITIA NHLYFWDVWY SYHFCKAKIK GYRRLISPNS CYDAFIVYDT
KDPAVTEWVL DELVAKLEDP REKCFNLCLE ERDWLPGQPV LENLSQSIQL SKKTVFVMTD
KYAKTENFKI AFYLSHQRLM DEKVDVIILI FLEKPLQKSK FLQLRKRLCG SSVLEWPTNP
QAHPYFWQCL KNALATDNHV TYSQVFKETA
//
