ID A1Z9I9_DROME Unreviewed; 5390 AA.
AC A1Z9I9;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 143.
DE SubName: Full=Short stop, isoform B {ECO:0000313|EMBL:AAG22268.2};
GN Name=shot {ECO:0000313|EMBL:AAG22268.2,
GN ECO:0000313|FlyBase:FBgn0013733};
GN Synonyms=42/4 {ECO:0000313|EMBL:AAG22268.2}, CG18637
GN {ECO:0000313|EMBL:AAG22268.2}, Dmel\CG18076
GN {ECO:0000313|EMBL:AAG22268.2}, Grv {ECO:0000313|EMBL:AAG22268.2}, grv
GN {ECO:0000313|EMBL:AAG22268.2}, Kak {ECO:0000313|EMBL:AAG22268.2}, kak
GN {ECO:0000313|EMBL:AAG22268.2}, kakp {ECO:0000313|EMBL:AAG22268.2}, kop
GN {ECO:0000313|EMBL:AAG22268.2}, l(2)CA4 {ECO:0000313|EMBL:AAG22268.2},
GN l(2)k03010 {ECO:0000313|EMBL:AAG22268.2}, l(2)k04204
GN {ECO:0000313|EMBL:AAG22268.2}, l(2)k05434
GN {ECO:0000313|EMBL:AAG22268.2}, l(2)k05821
GN {ECO:0000313|EMBL:AAG22268.2}, l(2)k10821
GN {ECO:0000313|EMBL:AAG22268.2}, l(2)k15606
GN {ECO:0000313|EMBL:AAG22268.2}, shortstop/kakapo
GN {ECO:0000313|EMBL:AAG22268.2}, Shot {ECO:0000313|EMBL:AAG22268.2},
GN Su(Mir)1 {ECO:0000313|EMBL:AAG22268.2};
GN ORFNames=CG18076 {ECO:0000313|EMBL:AAG22268.2,
GN ECO:0000313|FlyBase:FBgn0013733}, Dmel_CG18076
GN {ECO:0000313|EMBL:AAG22268.2};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAG22268.2, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AAG22268.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AAG22268.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AAG22268.2, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AAG22268.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AAG22268.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AAG22268.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AAG22268.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AAG22268.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AE013599; AAG22268.2; -; Genomic_DNA.
DR RefSeq; NP_725336.1; NM_166016.2.
DR SMR; A1Z9I9; -.
DR IntAct; A1Z9I9; 5.
DR EnsemblMetazoa; FBtr0087616; FBpp0086742; FBgn0013733.
DR GeneID; 36542; -.
DR UCSC; CG18076-RB; d. melanogaster.
DR AGR; FB:FBgn0013733; -.
DR CTD; 36542; -.
DR FlyBase; FBgn0013733; shot.
DR VEuPathDB; VectorBase:FBgn0013733; -.
DR GeneTree; ENSGT00950000185013; -.
DR OrthoDB; 5489926at2759; -.
DR BioGRID-ORCS; 36542; 0 hits in 3 CRISPR screens.
DR ChiTaRS; shot; fly.
DR GenomeRNAi; 36542; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0013733; Expressed in mouthpart and 30 other cell types or tissues.
DR ExpressionAtlas; A1Z9I9; baseline and differential.
DR Genevisible; A1Z9I9; DM.
DR GO; GO:0005912; C:adherens junction; IDA:FlyBase.
DR GO; GO:0000235; C:astral microtubule; IDA:FlyBase.
DR GO; GO:0044295; C:axonal growth cone; IDA:FlyBase.
DR GO; GO:0005737; C:cytoplasm; HDA:FlyBase.
DR GO; GO:0005856; C:cytoskeleton; NAS:FlyBase.
DR GO; GO:0030175; C:filopodium; IDA:FlyBase.
DR GO; GO:0045169; C:fusome; IDA:FlyBase.
DR GO; GO:0030426; C:growth cone; IDA:FlyBase.
DR GO; GO:0030056; C:hemidesmosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IDA:FlyBase.
DR GO; GO:0035371; C:microtubule plus-end; IDA:FlyBase.
DR GO; GO:0005927; C:muscle tendon junction; IDA:FlyBase.
DR GO; GO:0003779; F:actin binding; TAS:FlyBase.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; TAS:FlyBase.
DR GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; TAS:FlyBase.
DR GO; GO:0016199; P:axon midline choice point recognition; IMP:FlyBase.
DR GO; GO:0007409; P:axonogenesis; IMP:FlyBase.
DR GO; GO:0035147; P:branch fusion, open tracheal system; IMP:FlyBase.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0035149; P:lumen formation, open tracheal system; IMP:FlyBase.
DR GO; GO:0001578; P:microtubule bundle formation; IMP:FlyBase.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IMP:FlyBase.
DR GO; GO:0007017; P:microtubule-based process; NAS:FlyBase.
DR GO; GO:0016203; P:muscle attachment; TAS:FlyBase.
DR GO; GO:0016319; P:mushroom body development; IMP:FlyBase.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IMP:FlyBase.
DR GO; GO:0030716; P:oocyte fate determination; IMP:FlyBase.
DR GO; GO:0007424; P:open tracheal system development; IMP:FlyBase.
DR GO; GO:0045773; P:positive regulation of axon extension; IMP:FlyBase.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; IMP:FlyBase.
DR GO; GO:0030516; P:regulation of axon extension; IMP:FlyBase.
DR GO; GO:0042060; P:wound healing; IBA:GO_Central.
DR CDD; cd21188; CH_PLEC-like_rpt1; 1.
DR CDD; cd21189; CH_PLEC-like_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 17.
DR Gene3D; 1.20.58.60; -; 32.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 17.
DR Pfam; PF21020; Spectrin_4; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00250; PLEC; 2.
DR SMART; SM00150; SPEC; 37.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF75399; Plakin repeat; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 32.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A1Z9I9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 37..140
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 152..257
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 803..861
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 4956..4991
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 4992..5027
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 5032..5104
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 2176..2240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4823..4896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5131..5164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5176..5390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 368..452
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 943..970
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1855..1882
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1994..2021
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2261..2324
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2560..2587
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2778..2829
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2884..3020
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3104..3131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3424..3451
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4155..4220
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2212..2240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4870..4884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5131..5161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5179..5204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5212..5334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5345..5377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5390 AA; 615301 MW; 7B9C288020FF86DF CRC64;
MMDRESLSEW AKDKPLSILQ LDPADRAVLR IADERDAIQK KTFTKWVNKH LKKANRRVVD
LFEDLRDGHN LLSLLEVLSG EHLPREKGKM RFHMLQNAQM ALDFLRYKKI KLVNIRAEDI
VDGNPKLTLG LIWTIILHFQ ISDIVVGKED NVSAREALLR WARRSTARYP GVRVNDFTSS
WRDGLAFSAL VHRNRPDLLD WRKARNDRPR ERLETAFHIV EKEYGVTRLL DPEDVDTNEP
DEKSLITYIS SLYDVFPEPP SIHPLFDMES QRRVHEYRDL AQQFIYWCRE KTAYLQERSF
PPTLIEMKRL LSDLQRFRSD EVSARKREKS KLIQIYKELE RYFETVGEVD VEAELRPDAI
EKAWYRMNTA LQDREVILQQ EIERLERLQR LADKVQREIK HVDQKLTDLE GRIGEEGRRI
ERLHPVDAKS IVEALETEIR HLEEPIQDMN QDCHVLNEGR YPHVSELHKK VNKLHQRWAQ
LRTNFHTNLV QKLSGLKYPV HETTVTRQTR MVVESRQIDT NPHFRDLQEH IEWCQNKLKQ
LLAADYGSDL PSVKEELDRQ QHEHKIIDQF HTKILNDERQ QTKFSGDELA LYQQRLNQLQ
KVYAELLSTS TKRLSDLDSL QHFLGQASAE LQWLNEKEQV EITRDWADKQ LDLPSVHRYY
ENLMSELEKR EMHFATILDR GEALLNQQHP ASKCIEAHLT ALQQQWAWLL QLTLCLEVHL
KHATEYHQFF GEIKDAEQWL AKRDEILNSK FSQSDFGLDQ GETLLRGMQD LREELNAFGE
TVATLQRRAQ TVVPLNKRRQ PVNRQGPVQA ICAYKQQGQL QIEKGETVTL LDNSGRVKWR
VRTAKGQEGP IPGACLLLPP PDQEAIDAAE RLKRLFDRSV ALWQKKHLRL RQNMIFATIR
VVKGWDFDQF LAMGPEQRTA IRRALNDDAD KLLSEGDPND PQLRRLRREM DEVNRLFDEF
EKRARAEEES KQASRIFTEE CLAIKSKLED MARELDQIIL APLPRDLDSL EHVLEIHSDY
ERRLHLLEPE LKHLQETFRT IALKTPVLKK SLDNLMELWK ELNTQSGLHK DRLKLLEASL
AGLEDNEHVI SELENELARH QDLPSTAEGL QQVFKQLNHM QDIITQQQPQ MDKMNDAADQ
LGRMGVPTKV LGDLKRLHSN VERLNTRWSA VCNQLGERMR SCETAIGLMK NLQSSVQVEE
SWVDGTTERL SAMPTATSAY ELDKLLGAAI ERKPKIENVN VAGGRLIREA KIYDSKCLRF
VDWLVEARPS FSPPRRDLRP ADSDPGATQY YSQRLDNLNT KNDRLLEQLS QRLKTAIEVN
GSDGLQYAES LQKPLKTFRV DFSAGSVPTG DGYAARQEDL YTTTYSTTQI SSTKTTKSST
KSVYSSDGLD AASQEVSTAG LPQSQIQFNE IRTLKRSQQL GGHSVLDIAG IRDPRTGRVL
TIGEAIQLRI LDVRTGEMLV GDRRITLEQA ADQGLIDLQL AKQLLEPGAG RDASGRELSL
LEVIQREISE AESGYETAEK RIKQAVFEKF NMCEENVNDL LKWVTTVEQK ISSVGGPREK
IDELRNQINA LKQIKDEIES QQRPVATCLE QIRQIVLTGG DVLSAPEVTT LENSGRELRS
RVDRVNDRTV RLLRRLEAGR DELTKLRSEL DVFSDWLQVA RRTLEDKERS LSDLTRLPSQ
ADSVREFVSD VIGHQADLRF ITMAAQKFVD ESKEFLAILN DFRTSLPERL PHVEPLSSAE
SPIRQEVSLV SAQYKDLLNR VNALQDRVSG LGGRQREYQD ALDKANEWLR SVHPRVSRII
SEPIAGDPKG VQDQMNEAKA LHNELLSSGR LVDNAQQALD NLLRSLGGQL SPMEINQLEL
PIADLKNNYQ QLLDNLGEHC KTLDKTLVQS QGVQDALDSL VGWVNQAEDK FKMNLRPASL
IKERLQEQIR EHKVLLADLQ SHQASIDSVQ VSAKHLLASA SNARIAKKVE SNLNDVTVKF
EKLYEKANKR GEFLDDVYNR LSRYLDEIST VEQRMASLQE ALDSRETSLL STEELARRMN
ELSRDKDQLA PQFEDCVRSG KDLISLRDVT DTGVLRDRIK ALESQWRNIN ISIDERAKLS
KQKAEQQLAY EGLKDQVLSW LASTEARVNG LPPVAIDLDR IKQQHDELKP ICKDYRDYAP
TIDKINDIGA QYDALIRPES PARKRSTYSP IKRTSPLRRM SGDARSPSPT KGGILSPLST
GSSGFGSRRS SQDGFQLSEL SPVQQQLSEI NNRYGLIGVR LNDRQHELDN LNEELRKQYE
NLKGLAQFLE RIQRQLPKES VSNKDEAERC IKQARKILED MYEKQSLLDT TKAQVKDILR
RKSDVPGAEQ LRQENDSIQE KWKNLNDICK NRIAFSEKLR DFLDTHGNLK SWLDSKERML
TVLGPISSDP RMVQSQVQQV QVLREEFRTQ QPQLKHFQEL GHDVVDHLAG TPDAQAVEIK
LKDILGKWDD LVGKLDDRAN SLGGAADSSK EFDAAVNRLR EALQNISDNL DTLPTDGDHQ
ENLRKIENLE RQLEGQRPLL ADVEQSAATL CNILGDPASR ADVNSRVAAL EKQYLALQKK
LDTKKAETEA SLRDGRHFAE NCSKTLGWLG GELSNLTDRL LVSAHKPTLQ HQIDTHEPIY
REVMAREHEV IMLINKGKDL TDRQQDRGVK RDLDRIQQQW EKLRREAVDR HTRLQTCMEH
CKKYSQTSET FLAWLRTAED KLADLTPGVL SKAKLETRLR DLQTFRSEVW KHSGEFENTK
GLGETFLSSC DIDKEPIKAE LQDIRDRWER LNNDLIARAH EIENCSRRLD DFNDELRNLD
HSLGRCEDRL AAHDALGGAA KDPKLLERVK AIREELTNLS KPLQSLKALA KDISAEARAA
GGDADHLTSE VDGLADRMSE LQGRLDDRCG ELQSAATAVS QFNEQMKSLG IDLNDLETEI
EKLSPPGREI KIVQVQIDDV GKIQTKLDRL VGRLEDAERA ADVLVDAGFA ADTTQTREQI
STLRKTLGRL DNRVRDHEDN LHSTLKALRE FYDHQSQTLD DIQDVSDEFK RMKPVGSELD
QIRRQQEDFR NFRERKVEPL AINVDKVNVA GRDLVRSAGS GVSTTAIEKD LEKLNDRWND
LKERMNERDR RLDVALLQSG KFQEALAGLS KWLSDTEEMV ANQKPPSSDY KVVKAQLQEQ
KFLKKMLLDR QNSMGSLANL GKEVANHCEP GERASIEKQL NDLMKRFDAL TDGAEQRELD
LEEAMEVAKR FHDKISPLEL WLDNTERSVK AMELIPTDEE KIQQRIREHD RLHDEILGKK
PDFSDLADVT AQLMHLVSDE EAVNLGEKVR GVTERYTGLV DASDNIGALL AESRQGLRHL
VLSYQDLVAW MESMEAELKR FKSVPVYAEK LLEQMDHLLE LNENIAGHAS NVESTVESGA
ELMKHISNDE AIQLKDKLDS LQRRYGDLTN RGGDLLKSAQ NALPLVQQFH EAHNRLVEWM
QSAEAALAPS EPRQADVLRL EGELADMRPI LDSINQVGPQ LCQLSPGEGA ATIESIVTRD
NRRFDSIVEQ IQRKAERLHL SNQRAKEVTG DIDELLEWFR EMDTTLREAD LPAMEPKLVR
AQLQEHRSIN DDISSQKGRV RDVTAASKKV LRESPQSENT ATLREKLDDL KEIVDTVAQL
CSERLGILEQ ALPLSEHFAD SHQGLTAWLD DMEQQISRLS MPALRPDQIT LQQDKNERLL
QSIAEHKPLL DKLNKTGEAL GALVADDDGA KINEILDTDN ARYAALRLEL RERQQALESA
LQESSQFSDK LEGMLRALAN TVDQVNQLDP LSALPQKIRE QIEDNDALMD DLDKRQDAFS
AVQRAANDVI AKAGNKADPA VRDIKAKLEK LNNLWNDVQN ATKKRGSSLD DILSVAEPFW
KQLNSVMKTL KDLEETLSCQ EPPAAQPQDI KKQQVALQEI RHEIDQTKPE VEQVRRHGSN
LMNMCGEPDK PEVKKHIEDL DNAWDNITAL YAKREENLID AMEKAMEFHE TLQNLLKFLT
KAEDKFAHLG AVGSDIDAVK RQIEQLKSFK DEVDPHMVEV EALNRQAVEL TERTSPEQAA
SIREPLSVVN RRWEALLRGM VERQKQLEHA LLHLGQFQHA LNELLVWINK TDSTLDQLKP
IPGDPQLLEV ELAKLKVLAN DIQAHQNSVD TLNDAGRQLI ETEKGSVEAS TTQEKLRKLN
NEWKQLLQKA SDRQHELEEA LREAHGYIAE VQDILGWLGD VDAVIGASKP VGGLPETATE
QLERFMEVYN ELDENRPKVE TIQAQGQEYI KRQNQMKVSS SNLQHTLRTL KQRWDAVVSR
ASDKKIKLEI ALKEATEFHD TLQAFVEWLT QAEKLLSNAE PVSRVLETIQ AQMEEHKVLQ
KDVSTHREAM LLLDKKGTHL KYFSQKQDVI LIKNLLVSVQ HRWERVVSKA AERTRALDHG
YKEAREFNDA WSGMMQYLQE TEQVLDQIIE EATASKEPQK IKKYIGKLKE THRQLGAKQS
VYDGTMRTGK NLLERAPKGD RPVLDKMLIE LKEQWTRVWS KSIDRQRKLE EALLLSGQFS
DALGELLDWL KKAKSRLNEN GPVHGDLETV QGLCEHHKHI EQDLQKRAAQ MQGVLKTGRD
LERSGNNPEV GRQLDEMQSI WEEVKSAVAK RGERLQVALV DAEKLNARVQ ALFDWLDHAE
HKLRYAKNAP DDEKVSREMM DIHMDFMKDL RVREREKTET FEYAEDIINK AYPDAIPIIK
NWLSIIQQRW EEVRQWAINR ESKLEQHLQS LKDLDDTIEE LLAWLSGLEG TLLNLKHEQL
PDEIPPVEKL IEDHKEFMEN TARRQNEVDR ACKPRQLPPG ARKPSRSGKT PVFKGSRDQG
LNARKGSRIT PTRDTPDRDR LPHYGPRFSP STSGPELEFR SPRAKLLWTK WRDVWMLSWE
RQRLLNDHLL YLKDVERARN FSWDDWRKRF LKYMNHKKSR LTDLFRKMDK DNNGMIPRDV
FIDGILNTKF DTSGLEMKAV ADLFDRNGEG LIDWQEFIAA LRPDWQERKP ANDSDKIHDE
VKRLVMLCTC RQKFRVFQVG EGKYRFGDSQ KLRLVRILRS TVMVRVGGGW VALDEFLQKN
DPCRAKGRTN IELREQFILA DGVSQSMAAF TPRRSTPNAA ATASSSPHAH NGGSSNLPPY
MSGQGPIIKV RERSVRSIPM SRPSRSSLSA STPDSLSDNE GSHGGPSGRY TPRKVTYTST
RTGLTPGGSR AGSKPNSRPL SRQGSKPPSR HGSTLSLDST DDHTPSRIPQ RKPSTGSTAS
GTTPRPARLS VTTTTTPGSR LNGTSTITRK TASGSASPAP TSNGGMSRSS SIPALTGFGF
KPIRRNISGS STPSGMQTPR KSSAEPTFSS TMRRTSRGTT PTEKREPFRL
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