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Database: UniProt
Entry: A1ZRX9_9BACT
LinkDB: A1ZRX9_9BACT
Original site: A1ZRX9_9BACT 
ID   A1ZRX9_9BACT            Unreviewed;       493 AA.
AC   A1ZRX9;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   20-JUN-2018, entry version 72.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=M23134_04817 {ECO:0000313|EMBL:EAY26867.1};
OS   Microscilla marina ATCC 23134.
OC   Bacteria; Bacteroidetes; Cytophagia; Cytophagales; Microscillaceae;
OC   Microscilla.
OX   NCBI_TaxID=313606 {ECO:0000313|EMBL:EAY26867.1, ECO:0000313|Proteomes:UP000004095};
RN   [1] {ECO:0000313|EMBL:EAY26867.1, ECO:0000313|Proteomes:UP000004095}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23134 {ECO:0000313|EMBL:EAY26867.1,
RC   ECO:0000313|Proteomes:UP000004095};
RA   Haygood M., Podell S., Anderson C., Hopkinson B., Roe K., Barbeau K.,
RA   Gaasterland T., Ferriera S., Johnson J., Kravitz S., Beeson K.,
RA   Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAY26867.1}.
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DR   EMBL; AAWS01000029; EAY26867.1; -; Genomic_DNA.
DR   ProteinModelPortal; A1ZRX9; -.
DR   STRING; 313606.M23134_04817; -.
DR   EnsemblBacteria; EAY26867; EAY26867; M23134_04817.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004095; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004095};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004095}.
FT   DOMAIN      187    316       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      401    470       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     195    202       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      470    490       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   493 AA;  56514 MW;  7D64CCF3F6768865 CRC64;
     MENDSISVQK DCYTVWENCL KVIRTQIAEQ TYTTWFDPIK PLKLVDKVLT IQVPSRFFYE
     WLEEHYVHLL RKAIDASLGT EGRLEYTIIM EKQEKPYLPN HNSPQFVQNN DNHTKPQNSA
     PAQQKNYSNN NYNNVNNSPN TPKKTSQFNQ TFQINPRYTF ESFIEGDCNR LARSAGLAVA
     QKPGVTSFNP LMLYGGVGLG KTHLVQAIGN YVQENGQKKI LYVSSDRFTN QFIEALKNND
     LQSFTDYYMQ ADVLAIDDVQ FLSGKEKTQE IFFNIFNHLH QSGKQIIMTS DCPPKELKGL
     QERLLSRFKW GLTADLKQPD LETRIAIIHK ILQSEDNKNI EISGKVVEYL AHSIDSNVRE
     LEGAIVSIIA KASLNQSPIT MELAKQTVQQ IVQPVDSSEI NIDEVQKYVG DYFGVSVEML
     KSKTRKKEIV IARQIAMYFA KEYTGFSLKS IGYHFGGRDH STVIHAIQTV NDMMSEKKEL
     KMYIDDLRKK FSK
//
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