ID A2A6J8_MOUSE Unreviewed; 190 AA.
AC A2A6J8;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Troponin I, fast skeletal muscle {ECO:0000256|ARBA:ARBA00039349};
DE AltName: Full=Troponin I, fast-twitch isoform {ECO:0000256|ARBA:ARBA00042462};
DE Flags: Fragment;
GN Name=Tnni2 {ECO:0000313|Ensembl:ENSMUSP00000101593.3,
GN ECO:0000313|MGI:MGI:105070};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000101593.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000101593.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101593.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000101593.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101593.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin
CC filament regulatory complex which confers calcium-sensitivity to
CC striated muscle actomyosin ATPase activity.
CC {ECO:0000256|ARBA:ARBA00001988}.
CC -!- SUBUNIT: Binds to actin and tropomyosin.
CC {ECO:0000256|ARBA:ARBA00038767}.
CC -!- SIMILARITY: Belongs to the troponin I family.
CC {ECO:0000256|ARBA:ARBA00009930}.
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DR AlphaFoldDB; A2A6J8; -.
DR SMR; A2A6J8; -.
DR MaxQB; A2A6J8; -.
DR ProteomicsDB; 355508; -.
DR Antibodypedia; 4359; 481 antibodies from 34 providers.
DR Ensembl; ENSMUST00000105973.3; ENSMUSP00000101593.3; ENSMUSG00000031097.16.
DR AGR; MGI:105070; -.
DR MGI; MGI:105070; Tnni2.
DR VEuPathDB; HostDB:ENSMUSG00000031097; -.
DR GeneTree; ENSGT01030000234588; -.
DR HOGENOM; CLU_098686_1_0_1; -.
DR PhylomeDB; A2A6J8; -.
DR ChiTaRS; Tnni2; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000031097; Expressed in digastric muscle group and 131 other cell types or tissues.
DR ExpressionAtlas; A2A6J8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005861; C:troponin complex; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0031014; F:troponin T binding; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0090076; P:relaxation of skeletal muscle; IEA:Ensembl.
DR GO; GO:0003009; P:skeletal muscle contraction; IEA:Ensembl.
DR Gene3D; 1.20.5.350; -; 1.
DR Gene3D; 6.10.250.180; -; 1.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR13738; TROPONIN I; 1.
DR PANTHER; PTHR13738:SF15; TROPONIN I, FAST SKELETAL MUSCLE; 1.
DR Pfam; PF00992; Troponin; 2.
DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Proteomics identification {ECO:0007829|MaxQB:A2A6J8,
KW ECO:0007829|ProteomicsDB:A2A6J8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT COILED 13..42
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000101593.3"
SQ SEQUENCE 190 AA; 22201 MW; F21880A8A4F43484 CRC64;
KRNRAITARR QHLKSVMLQI AATELEKEES RRESEKENYL SEHCPPLHIP GSMSEVQVSG
WPPTHCLPTQ ELCKQLHAKI DVAEEEKYDM EVKVQKSSKE LEDMNQKLFD LRGKFKRPPL
RRVRMSADAM LKALLGSKHK VCMDLRANLK QVKKEDTEKE RDLRDVGDWR KNIEEKSGME
GRKKMFESES
//
