ID A2A6K0_MOUSE Unreviewed; 135 AA.
AC A2A6K0;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=Troponin I, fast skeletal muscle {ECO:0000256|ARBA:ARBA00039349};
DE AltName: Full=Troponin I, fast-twitch isoform {ECO:0000256|ARBA:ARBA00042462};
DE Flags: Fragment;
GN Name=Tnni2 {ECO:0000313|Ensembl:ENSMUSP00000121819.2,
GN ECO:0000313|MGI:MGI:105070};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000121819.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000121819.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000121819.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000121819.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000121819.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the thin
CC filament regulatory complex which confers calcium-sensitivity to
CC striated muscle actomyosin ATPase activity.
CC {ECO:0000256|ARBA:ARBA00001988}.
CC -!- SUBUNIT: Binds to actin and tropomyosin.
CC {ECO:0000256|ARBA:ARBA00038767}.
CC -!- SIMILARITY: Belongs to the troponin I family.
CC {ECO:0000256|ARBA:ARBA00009930}.
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DR AlphaFoldDB; A2A6K0; -.
DR SMR; A2A6K0; -.
DR MaxQB; A2A6K0; -.
DR ProteomicsDB; 351502; -.
DR Antibodypedia; 4359; 481 antibodies from 34 providers.
DR Ensembl; ENSMUST00000145287.8; ENSMUSP00000121819.2; ENSMUSG00000031097.16.
DR AGR; MGI:105070; -.
DR MGI; MGI:105070; Tnni2.
DR VEuPathDB; HostDB:ENSMUSG00000031097; -.
DR GeneTree; ENSGT01030000234588; -.
DR OMA; KRHRAIT; -.
DR ChiTaRS; Tnni2; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000031097; Expressed in digastric muscle group and 131 other cell types or tissues.
DR ExpressionAtlas; A2A6K0; baseline and differential.
DR GO; GO:0005861; C:troponin complex; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.350; -; 1.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR13738; TROPONIN I; 1.
DR PANTHER; PTHR13738:SF15; TROPONIN I, FAST SKELETAL MUSCLE; 1.
DR Pfam; PF00992; Troponin; 1.
DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Proteomics identification {ECO:0007829|MaxQB:A2A6K0,
KW ECO:0007829|ProteomicsDB:A2A6K0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT REGION 29..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 135
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000121819.2"
SQ SEQUENCE 135 AA; 15735 MW; 9B0FFDC89270F4AB CRC64;
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KENYLSEHCP PLHIPGSMSE
VQELCKQLHA KIDVAEEEKY DMEVKVQKSS KELEDMNQKL FDLRGKFKRP PLRRVRMSAD
AMLKALLGSK HKVCM
//
