ID A2A7T3_MOUSE Unreviewed; 1290 AA.
AC A2A7T3;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=Arginine glutamic acid dipeptide (RE) repeats {ECO:0000313|Ensembl:ENSMUSP00000101305.3};
GN Name=Rere {ECO:0000313|Ensembl:ENSMUSP00000101305.3,
GN ECO:0000313|MGI:MGI:2683486};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000101305.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000101305.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101305.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0007829|PubMed:23806337}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000101305.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000101305.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; A2A7T3; -.
DR jPOST; A2A7T3; -.
DR MaxQB; A2A7T3; -.
DR PeptideAtlas; A2A7T3; -.
DR ProteomicsDB; 349669; -.
DR Antibodypedia; 13215; 182 antibodies from 24 providers.
DR Ensembl; ENSMUST00000105680.9; ENSMUSP00000101305.3; ENSMUSG00000039852.18.
DR AGR; MGI:2683486; -.
DR MGI; MGI:2683486; Rere.
DR VEuPathDB; HostDB:ENSMUSG00000039852; -.
DR GeneTree; ENSGT00940000153615; -.
DR ChiTaRS; Rere; mouse.
DR Proteomes; UP000000589; Chromosome 4.
DR Bgee; ENSMUSG00000039852; Expressed in vestibular membrane of cochlear duct and 274 other cell types or tissues.
DR ExpressionAtlas; A2A7T3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11661; SANT_MTA3_like; 1.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 4.10.1240.50; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR002951; Atrophin-like.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR000679; Znf_GATA.
DR PANTHER; PTHR13859:SF12; ARGININE-GLUTAMIC ACID DIPEPTIDE REPEATS PROTEIN; 1.
DR PANTHER; PTHR13859; ATROPHIN-RELATED; 1.
DR Pfam; PF03154; Atrophin-1; 1.
DR Pfam; PF01448; ELM2; 1.
DR Pfam; PF00320; GATA; 1.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 1.
DR SMART; SM00401; ZnF_GATA; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:A2A7T3,
KW ECO:0007829|MaxQB:A2A7T3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022771};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 16..119
FT /note="ELM2"
FT /evidence="ECO:0000259|PROSITE:PS51156"
FT DOMAIN 123..175
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..513
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..573
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..673
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..735
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..789
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..934
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1290 AA; 140913 MW; 334B2F238EE7AD06 CRC64;
MDDPFSPCRR LNSTQGEIRV GPSHQAKLPD LQPFPSPDGD TVTQHEELVW MPGVSDCDLL
MYLRAARSMA AFAGMCDGGS TEDGCVAASR DDTTLNALNT LHESSYDAGK ALQRLVKKPV
PKLIEKCWTE DEVKRFVKGL RQYGKNFFRI RKELLPSKET GELITFYYYW KKTPEAASSR
AHRRHRRQAV FRRIKTRTAS TPVNTPSRPP SSEFLDLSSA SEDDFDSEDS EQELKGYACR
HCFTTTSKDW HHGGRENILL CTDCRIHFKK YGELPPIEKP VDPPPFMFKP VKEEDDGLSG
KHSMRTRRSR GSMSTLRSGR KKQPTSPDGR ASPINEDIRS SGRNSPSAAS TSSNDSKAET
VKKSAKKVKE EAASPLKSTK RQREKVASDT EDTDRITSKK TKTQEISRPN SPSEGEGESS
DSRSVNDEGS SDPKDIDQDN RSTSPSIPSP QDNESDSDSS AQQQMLQAQP PALQAPSGAA
SAPSTAPPGT PQLPTQGPTP SATAVPPQGS PATSQPPNQT QSTVAPAAHT HIQQAPTLHP
PRLPSPHPPL QPMTAPPSQS SAQPHPQPSL HSQGPPGPHS LQTGPLLQHP GPPQPFGLPS
QPSQGQGPLG PSPAAAHPHS TIQLPASQSA LQPQQPPREQ PLPPAPLAMP HIKPPPTTPI
PQLPAPQAHK HPPHLSGPSP FSLNANLPPP PALKPLSSLS THHPPSAHPP PLQLMPQSQP
LPSSPAQPPG LTQSQSLPPP AASHPTTGLH QVPSQSPFPQ HPFVPGGPPP ITPPSCPPTS
TPPAGPSSSS QPPCSAAVSS GGSVPGAPSC PLPAVQIKEE ALDEAEEPES PPPPPRSPSP
EPTVVDTPSH ASQSARFYKH LDRGYNSCAR TDLYFMPLAG SKLAKKREEA IEKAKREAEQ
KAREEREREK EKEKERERER EREREAERAA KASSSAHEGR LSDPQLSGPG HMRPSFEPPP
TTIAAVPPYI GPDTPALRTL SEYARPHVMS PTNRNHPFYM PLNPTDPLLA YHMPGLYNVD
PTIRERELRE REIREREIRE RELRERMKPG FEVKPPELDP LHPATNPMEH FARHSALTIP
PAAGPHPFAS FHPGLNPLER ERLALAGPQL RPEMSYPDRL AAERIHAERM ASLTSDPLAR
LQMFNVTPHH HQHSHIHSHL HLHQQDPLHQ GSAGPVHPLV DPLTAGPHLA RFPYPPGTLP
NPLLGQPPHE HEMLRHPVFG TPYPRDLPGA IPPPMSAAHQ LQAMHAQSAE LQRLAMEQQW
LHGHPHMHGG HLPSQEDYYS RLKKEGDKQL
//
