ID A2A8V9_MOUSE Unreviewed; 918 AA.
AC A2A8V9;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 24-JAN-2024, entry version 116.
DE SubName: Full=Serine/arginine repetitive matrix 1 {ECO:0000313|Ensembl:ENSMUSP00000081906.6};
GN Name=Srrm1 {ECO:0000313|Ensembl:ENSMUSP00000081906.6,
GN ECO:0000313|MGI:MGI:1858303};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000081906.6, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:15345747}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [2] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [3] {ECO:0007829|PubMed:18630941}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18630941; DOI=10.1021/pr800223m;
RA Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
RT "Specific phosphopeptide enrichment with immobilized titanium ion affinity
RT chromatography adsorbent for phosphoproteome analysis.";
RL J. Proteome Res. 7:3957-3967(2008).
RN [4] {ECO:0007829|PubMed:19144319}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [5] {ECO:0007829|PubMed:19131326}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19131326; DOI=10.1074/mcp.M800451-MCP200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [6] {ECO:0000313|Ensembl:ENSMUSP00000081906.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000081906.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [7] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [8] {ECO:0007829|PubMed:23806337}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [9] {ECO:0000313|Ensembl:ENSMUSP00000081906.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000081906.6};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR RefSeq; NP_001123949.1; NM_001130477.1.
DR AlphaFoldDB; A2A8V9; -.
DR SMR; A2A8V9; -.
DR iPTMnet; A2A8V9; -.
DR EPD; A2A8V9; -.
DR jPOST; A2A8V9; -.
DR MaxQB; A2A8V9; -.
DR PeptideAtlas; A2A8V9; -.
DR ProteomicsDB; 367504; -.
DR Antibodypedia; 30330; 156 antibodies from 22 providers.
DR DNASU; 51796; -.
DR Ensembl; ENSMUST00000084846.12; ENSMUSP00000081906.6; ENSMUSG00000028809.17.
DR GeneID; 51796; -.
DR UCSC; uc008vge.2; mouse.
DR AGR; MGI:1858303; -.
DR CTD; 10250; -.
DR MGI; MGI:1858303; Srrm1.
DR VEuPathDB; HostDB:ENSMUSG00000028809; -.
DR GeneTree; ENSGT00730000111080; -.
DR OrthoDB; 276172at2759; -.
DR BioGRID-ORCS; 51796; 27 hits in 80 CRISPR screens.
DR ChiTaRS; Srrm1; mouse.
DR Proteomes; UP000000589; Chromosome 4.
DR Bgee; ENSMUSG00000028809; Expressed in embryonic post-anal tail and 273 other cell types or tissues.
DR ExpressionAtlas; A2A8V9; baseline and differential.
DR Genevisible; A2A8V9; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR002483; PWI_dom.
DR InterPro; IPR036483; PWI_dom_sf.
DR PANTHER; PTHR23148; SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN; 1.
DR PANTHER; PTHR23148:SF0; SERINE/ARGININE REPETITIVE MATRIX PROTEIN 1; 1.
DR Pfam; PF01480; PWI; 1.
DR SMART; SM00311; PWI; 1.
DR SUPFAM; SSF101233; PWI domain; 1.
DR PROSITE; PS51025; PWI; 1.
PE 1: Evidence at protein level;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Proteomics identification {ECO:0007829|EPD:A2A8V9,
KW ECO:0007829|MaxQB:A2A8V9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 27..126
FT /note="PWI"
FT /evidence="ECO:0000259|PROSITE:PS51025"
FT REGION 142..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..206
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..342
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..407
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..522
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..607
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..650
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..709
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..848
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..909
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 918 AA; 103716 MW; 7E1EF05D352FB6B6 CRC64;
MDAGFFRGTS AEQDNRFSNK QKKLLKQLKF AECLEKKVDM SKVNLEVIKP WITKRVTEIL
GFEDDVVIEF IFNQLEVKNP DSKMMQINLT GFLNGKNARE FMGELWPLLL SAQENIAGIP
SAFLELKKEE IKQRQIEQEK LASLKKQDED KDKRDKEEKE SSREKRERSR SPRRRKSRSP
SPRRRSSPVR RERKRSHSRS PRHRTKSRSP SPAPEKKEKS PELPEPSVRM KDSSVQEATS
TSDILKAPKP EPVPEPKEPS PEKNSKKEKE KTRPRSRSRS KSRSRTRSRS PSHTRPRRRH
RSRSRRRPSP RRRPSPRRRT PPRRMPPPPR HRRSRSPGRR RRRSSASLSG SSSSSSSSRS
RSPPKKPPKR TSSPPRKTRR LSPSASPPRR RHRPSSPATP PPKTRHSPTP QQSNRTRKSR
VSVSPGRTSG KVTKHKGTEK RESPSPAPKP RKVELSESEE DKGSKMAAAD SVQQRRQYRR
QNQQSSSDSG SSSTSEDERP KRSHVKNGEV GRRRRHSPSR SASPSPRKRQ KETSPRMQMG
KRWQSPVTKS SRRRRSPSPP PARRRRSPSP APPPPPPPPP PRRRRSPTPP PRRRTPSPPP
RRRSPSPRRY SPPIQRRYSP SPPPKRRTAS PPPPPKRRAS PSPPPKRRVS HSPPPKQRSP
TVTKRRSPSL SSKHRKGSSP GRSTREARSP QPNKRHSPSP RPRAPQTSSP PPVRRGASAS
PQGRQSPSPS TRPIRRVSRT PEPKKIKKAA SPSPQSVRRV SSSRSVSGSP EPAAKKPPAP
PSPVQSQSPS TNWSPAVPAK KAKSPTPSLS PARNSDQEGG GKKKKKKKDK KHKKDKKHKK
HKKHKKEKAV TIATPATAAP AAVSAATTTS AQEEPAAAPE PRKETESEAE DDNLDDLERH
LREKALRSMR KAQVSPQS
//