ID A2AAZ6_HUMAN Unreviewed; 260 AA.
AC A2AAZ6;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 27-MAR-2024, entry version 132.
DE SubName: Full=E3 ubiquitin-protein ligase TRIM39 {ECO:0000313|Ensembl:ENSP00000388969.1};
DE SubName: Full=Tripartite motif containing 39 {ECO:0000313|Ensembl:ENSP00000406019.1};
DE Flags: Fragment;
GN Name=TRIM39 {ECO:0000313|Ensembl:ENSP00000406019.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000406019.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000406019.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000406019.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL662795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL773535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX294158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteomicsDB; 317; -.
DR Antibodypedia; 34966; 297 antibodies from 30 providers.
DR Ensembl; ENST00000428728.5; ENSP00000406019.1; ENSG00000204599.16.
DR Ensembl; ENST00000431871.5; ENSP00000388969.1; ENSG00000230308.10.
DR Ensembl; ENST00000440130.5; ENSP00000407903.1; ENSG00000224994.10.
DR Ensembl; ENST00000442914.5; ENSP00000389389.1; ENSG00000226437.10.
DR Ensembl; ENST00000447077.5; ENSP00000400264.1; ENSG00000206495.12.
DR Ensembl; ENST00000449396.5; ENSP00000415414.1; ENSG00000232839.10.
DR Ensembl; ENST00000450421.5; ENSP00000416850.1; ENSG00000229929.10.
DR UCSC; uc063mrh.1; human.
DR HGNC; HGNC:10065; TRIM39.
DR VEuPathDB; HostDB:ENSG00000204599; -.
DR GeneTree; ENSGT00940000154126; -.
DR HOGENOM; CLU_013137_6_1_1; -.
DR OMA; VCEISHE; -.
DR ChiTaRS; TRIM39; human.
DR Proteomes; UP000005640; Chromosome 6.
DR Bgee; ENSG00000204599; Expressed in granulocyte and 103 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19780; Bbox2_TRIM39-like; 1.
DR CDD; cd16594; RING-HC_TRIM7-like_C-IV; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF639; E3 UBIQUITIN-PROTEIN LIGASE TRIM39; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 29..70
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 102..143
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT COILED 190..221
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 260
FT /evidence="ECO:0000313|Ensembl:ENSP00000406019.1"
SQ SEQUENCE 260 AA; 30010 MW; 59D0C3794B84C26A CRC64;
MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK ACITRWWEDL
ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK IRDESLCPQH HEALSLFCYE
DQEAVCLICA ISHTHRAHTV VPLDDATQEY KEKLQKCLEP LEQKLQEITR CKSSEEKKPG
ELKRLVESRR QQILREFEEL HRRLDEEQQV LLSRLEEEEQ DILQRLRENA AHLGDKRRDL
AHLAAEVEGK CLQSGFEMLK
//