ID A2AF67_MOUSE Unreviewed; 1902 AA.
AC A2AF67;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE SubName: Full=Dedicator of cytokinesis 11 {ECO:0000313|Ensembl:ENSMUSP00000110921.2};
GN Name=Dock11 {ECO:0000313|Ensembl:ENSMUSP00000110921.2,
GN ECO:0000313|MGI:MGI:1923224};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000110921.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000110921.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000110921.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000110921.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000110921.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR SMR; A2AF67; -.
DR EPD; A2AF67; -.
DR MaxQB; A2AF67; -.
DR PeptideAtlas; A2AF67; -.
DR ProteomicsDB; 365437; -.
DR Antibodypedia; 29701; 67 antibodies from 17 providers.
DR Ensembl; ENSMUST00000115266.8; ENSMUSP00000110921.2; ENSMUSG00000031093.15.
DR AGR; MGI:1923224; -.
DR MGI; MGI:1923224; Dock11.
DR VEuPathDB; HostDB:ENSMUSG00000031093; -.
DR GeneTree; ENSGT00940000155658; -.
DR HOGENOM; CLU_000624_1_0_1; -.
DR ChiTaRS; Dock11; mouse.
DR Proteomes; UP000000589; Chromosome X.
DR Bgee; ENSMUSG00000031093; Expressed in manus and 224 other cell types or tissues.
DR ExpressionAtlas; A2AF67; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11700; DHR2_DOCK11; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF81; DEDICATOR OF CYTOKINESIS PROTEIN 11; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:A2AF67,
KW ECO:0007829|MaxQB:A2AF67};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1..88
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 456..634
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1438..1865
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1056..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1902 AA; 218244 MW; 019B4D61A8DB843F CRC64;
MKVFKRRYFY LTQLPDGSYI LNSYKDEKNS KESKGCIYLD ACIDVVQCPK MRRHAFELKM
LDKYSHYLAA ETEQEMEEWL IMLKKIIQIN TDSLVQEKKD TVEAIQEEET SSQGKAENIM
ASLERSMHPE LMKYGRETEQ LNKLSRGDGR QNLFSFDSEV QRLDFSGIEP DVKPFEEKCN
KRFMVNCHDL TFNILGHIGD NAKGPPTNVE PFFINLALFD VKNNCKISAD FHVDLNPPSV
REMLWGTSTQ LSNDGNAKGF SPESLIHGIA ESQLCYIKQG IFSVTNPHPE IFLVVRIEKV
LQGNITHCAE PYIKNSDPIK TAQKVHRTAK QVCSRLGQYR MPFAWAARPI FKDVQGSLDL
DGRFSPLYKQ DSSKLSNEDI LKLLSEYKKP EKTKLQIIPG QLSITVECVP VDLPNCITSS
YVPLKPFEKN CQNITVEVEE FVPEMTKYCY PFTIYKNHLY VYPLQLKYDS QKSFAKARNI
AVCVEFRDSD ESDASALKCI YGKPAGSVFT TNAYAVVSHH NQNPEFYDEI KIELPIHLHQ
KHHLLFTFYH VSCEINTKGT TKKQDTVETP VGFAWVPLLK DGRVITLEQQ LPVSANLPPG
YLNVNDAESR RQSNADIKWV DGAKPLLKIK THLESTIYTQ DLHVHKFFHH CQLIQSGSKE
VPGELIKYLK CLHAMEIQVM IQFLPVILMQ LFRVLTNMTH EDDVPINCTM VLLHIVSKCH
EEGLESYLRS FIKYSFRPEK PSTLQAQLIH ETLATTMIAI LKQSADFLAI NKLLKYSWFF
FEIIAKSMAT YLLEENKIKL PRGQRFPEAY HHVLHSLLLA IIPHVTIRYA EIPDESRNGN
YSLASFLKRC LTLMDRGFVF NLINDYISGF SPKDPKVLAE YKFEFLQTIC NHEHYIPLNL
PMAFAKPKLQ RVQDFFSFAV DRLTSVDSNL EYSLSDEYCK HHFLVGLLLR ETSIALQDNY
EIRYTAISVI KNLLIKHAFD TRYQHKNQQA KIAQLYLPFV GLLLENIQRL AGRDTLYSCA
AMPSSASRDE FPCGFVSPTN RGSLASDKDT AYGSFQNGHG IKREDSRGSL IPEGATGFPD
PGSTSENTRQ SSSRSSVSQY NRLDQYEIRN LLMCYLYIVK MISEDTLLTY WNKVSPQELI
NILVLLEVCL FHFRYMGKRN IARVHDAWLS KHFGIDRKSQ TMPALRNRSG VMQARLQHLS
SLESSFTLNH SSATTEADIF HQALLEGNTA TEVSLTVLDT ISFFTQCFKN QLLNNDGHNP
LMKKVFDIHL AFLKNGQSEV SLKHVFASLR SFISKFPSAF FKGRVNMCAA FCYEVLKCCT
SKISSTRNEA SALLYLLMRN NFEYTKRKTF LRTHLQIIIA VSQLIADVAL SGGSRFQESL
FIINNFANSD RPMKATAFPT EVKDLTKRIR TVLMATAQMK EHEKDPEMLI DLQYSLAKSY
ASTPELRKTW LDSMAKIHIK NGDFSEAAMC YVHVAALVAE FLHRKKLFPS GCSAFKKITP
NIDEEGAMKE DAGMMDVHYS EEVLLELLEQ CVDGLWKAER YEVISEISKL IIPIYEKRRE
FEKLTQVYRT LHGAYTKILE VMHTKKRLLG TFFRVAFYGQ SFFEEEDGKE YIYKEPKLTG
LSEISLRLVK LYGEKFGTEN VKIIQDSDKV NAKELDPKFA HIQVTYVKPY FDDKELTERK
TEFERNHNIN RFVFEAPYTL SGKKQGCIEE QCKRRTILTT SNSFPYVKKR IPINCEQQVN
LKPIDVATDE IKDKTAELHK LCSSVDVDMI QLQLKLQGCV SVQVNAGPLA YARAFLNESQ
ANKYPPKKVN ELKDMFRKFI QACSIALELN ERLIKEDQIE YHEGLKSNFR DMVKELSDII
HEQILQEDTM HSPWMNNTLH VFCAISGTSS NRGYGSPRYA EV
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