GenomeNet

Database: UniProt
Entry: A2AGX3
LinkDB: A2AGX3
Original site: A2AGX3 
ID   PRD11_MOUSE             Reviewed;         565 AA.
AC   A2AGX3; A2AGX2; A2AGX4;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   16-JAN-2019, entry version 82.
DE   RecName: Full=PR domain-containing protein 11;
DE            EC=2.1.1.-;
GN   Name=Prdm11;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3]
RP   TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=25499759; DOI=10.1182/blood-2014-03-560805;
RA   Fog C.K., Asmar F., Come C., Jensen K.T., Johansen J.V., Kheir T.B.,
RA   Jacobsen L., Friis C., Louw A., Rosgaard L., Obro N.F., Marquart H.V.,
RA   Anthonsen K., Braat A.K., van Lohuizen M., Ralfkiaer E., Gronbaek K.,
RA   Lund A.H.;
RT   "Loss of PRDM11 promotes MYC-driven lymphomagenesis.";
RL   Blood 125:1272-1281(2015).
CC   -!- FUNCTION: May be involved in transcription regulation.
CC       {ECO:0000250|UniProtKB:Q9NQV5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NQV5}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q9NQV5}.
CC   -!- TISSUE SPECIFICITY: Widely expressed, with the highest levels in
CC       spleen, lung, mesenteric lymph node and kidney. Among splenocytes,
CC       predominantly expressed by B-cells (at protein level).
CC       {ECO:0000269|PubMed:25499759}.
CC   -!- DISRUPTION PHENOTYPE: Mutant mice are born in expected Mendelian
CC       ratios and exhibit no apparent phenotype. Mutant embryonic
CC       fibroblasts show an increased oncogenic transformation capacity.
CC       {ECO:0000269|PubMed:25499759}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAM14370.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAM14372.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AL713913; CAM14370.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL713913; CAM14371.1; -; Genomic_DNA.
DR   EMBL; AL713913; CAM14372.1; ALT_SEQ; Genomic_DNA.
DR   CCDS; CCDS50647.1; -.
DR   RefSeq; NP_001171007.1; NM_001177536.1.
DR   UniGene; Mm.102816; -.
DR   UniGene; Mm.483087; -.
DR   ProteinModelPortal; A2AGX3; -.
DR   SMR; A2AGX3; -.
DR   STRING; 10090.ENSMUSP00000106905; -.
DR   iPTMnet; A2AGX3; -.
DR   PhosphoSitePlus; A2AGX3; -.
DR   MaxQB; A2AGX3; -.
DR   PaxDb; A2AGX3; -.
DR   PRIDE; A2AGX3; -.
DR   Ensembl; ENSMUST00000111274; ENSMUSP00000106905; ENSMUSG00000075028.
DR   Ensembl; ENSMUST00000178666; ENSMUSP00000136795; ENSMUSG00000075028.
DR   GeneID; 100042784; -.
DR   KEGG; mmu:100042784; -.
DR   UCSC; uc012bzp.1; mouse.
DR   CTD; 56981; -.
DR   MGI; MGI:2685553; Prdm11.
DR   eggNOG; ENOG410IN44; Eukaryota.
DR   eggNOG; ENOG410ZHQ1; LUCA.
DR   GeneTree; ENSGT00940000159837; -.
DR   HOGENOM; HOG000231444; -.
DR   HOVERGEN; HBG053665; -.
DR   InParanoid; A2AGX3; -.
DR   OMA; KLVWMRL; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; A2AGX3; -.
DR   TreeFam; TF316279; -.
DR   ChiTaRS; Prdm11; mouse.
DR   PRO; PR:A2AGX3; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000075028; Expressed in 177 organ(s), highest expression level in lumbar subsegment of spinal cord.
DR   ExpressionAtlas; A2AGX3; baseline and differential.
DR   Genevisible; A2AGX3; MM.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0001047; F:core promoter binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:2000271; P:positive regulation of fibroblast apoptotic process; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR   GO; GO:0043408; P:regulation of MAPK cascade; ISS:UniProtKB.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; Isopeptide bond; Methyltransferase;
KW   Nucleus; Phosphoprotein; Reference proteome; S-adenosyl-L-methionine;
KW   Transcription; Transcription regulation; Transferase; Ubl conjugation.
FT   CHAIN         1    565       PR domain-containing protein 11.
FT                                /FTId=PRO_0000416113.
FT   DOMAIN      115    226       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   MOD_RES      29     29       Phosphoserine.
FT                                {ECO:0000244|PubMed:21183079}.
FT   CROSSLNK     54     54       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q9NQV5}.
FT   CROSSLNK    121    121       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q9NQV5}.
FT   CROSSLNK    138    138       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q9NQV5}.
FT   CROSSLNK    166    166       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q9NQV5}.
FT   CROSSLNK    180    180       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in SUMO2).
FT                                {ECO:0000250|UniProtKB:Q9NQV5}.
SQ   SEQUENCE   565 AA;  63383 MW;  20FB804E1834B418 CRC64;
     MTENMKECLA HTKAAVGDMV TVVKTEVCSP LRDQEYGQPC SRRLEPSSME VEPKKLKGKR
     DLIVTKSFQQ VDFWFCESCQ EYFVDECPNH GPPVFVSDTP VPVGIPDRAA LTIPQGMEVV
     KDAGGESDVR CINEVIPKGH IFGPYEGQIS TQDKSAGFFS WLIVDKNNRY KSIDGSDETK
     ANWMRYVVIS REEREQNLLA FQHSERIYFR ACRDIRPGER LRVWYSEDYM KRLHSMSQET
     IHRNLARGEK RLQREKAEQA LENPEDLRGP TQFPVLKQGR SPYKRSFDEG DIHPQAKKKK
     IDLIFKDVLE ASLESGNVEA RQLALSTSLV IRKVPKYQDD DYGRAALTQG ICRTPGEGDW
     KVPQRVAKEL GPLEDEEEEP TSFKADSPAE ASLASDPHEL PTTSFCPNCI RLKKKVRELQ
     AELDMLKSGK LPEPSLLPPQ VLELPEFSDP AGKFLRMRLL LKGRVCSATR AHCVEGGPER
     SALSQPPARR PEECNSAEAA PSWGGSPVPQ VTEAGWLEDR GREGIACANL YILLVNKICP
     ICRRAVCCVL DLVFSLGGGA HCCLP
//
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