ID A2AHC4_MOUSE Unreviewed; 1077 AA.
AC A2AHC4;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Calmodulin regulated spectrin-associated protein 1 {ECO:0000313|Ensembl:ENSMUSP00000117203.2};
DE Flags: Fragment;
GN Name=Camsap1 {ECO:0000313|Ensembl:ENSMUSP00000117203.2,
GN ECO:0000313|MGI:MGI:3036242};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000117203.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000117203.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117203.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000117203.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000117203.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A2AHC4; -.
DR IntAct; A2AHC4; 1.
DR MINT; A2AHC4; -.
DR jPOST; A2AHC4; -.
DR MaxQB; A2AHC4; -.
DR ProteomicsDB; 318700; -.
DR Antibodypedia; 18656; 145 antibodies from 20 providers.
DR Ensembl; ENSMUST00000134882.8; ENSMUSP00000117203.2; ENSMUSG00000026933.19.
DR AGR; MGI:3036242; -.
DR MGI; MGI:3036242; Camsap1.
DR VEuPathDB; HostDB:ENSMUSG00000026933; -.
DR GeneTree; ENSGT00950000182975; -.
DR HOGENOM; CLU_004833_0_0_1; -.
DR ChiTaRS; Camsap1; mouse.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000026933; Expressed in embryonic post-anal tail and 241 other cell types or tissues.
DR ExpressionAtlas; A2AHC4; baseline and differential.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR PANTHER; PTHR21595:SF3; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|EPD:A2AHC4,
KW ECO:0007829|MaxQB:A2AHC4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 235..350
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 371..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 891..921
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1026..1053
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 371..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..641
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1077
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000117203.2"
SQ SEQUENCE 1077 AA; 119732 MW; 4CB67F2FA7670ED0 CRC64;
MVDAGGRCAA EGWRRMEAPP EGADLVPLDR YDAARAKIAA NLQWICAKAY GLDNIPEDLR
DPFYIDQYEQ EHIKPPVIKL LLSSELYCRV CSLILKGDQV ATLQGHQSVI QALSRKGIYV
MESDDTPVTD ADLSQAPIKM SGHMAMVDAL MMAYTVEMIS IEKVVASVKR FSTFSASKEL
PYDLEDAMVF WINKVNLKMR EITEKEVKLK QQPLESPAHQ KPGLEHAVMH CMLEPVDFAR
VVRYRREHLS ARQSPYFPLL EDLMRDGSDG AALLAVVHYY CPEQMKLDDI CLKEVPSMAD
SLYNIRLLRE FSNEHLNKCF YLTLEDMLYA PLVLKPNVMV FIAELFWWFE NVKPDFVQPR
DIQELKDAKT VLQQKSSRPP VPISNATKRS FLGSPAAMSP ADQPPSTQPL AEGSHRYHLH
SEEPECLGKG ASTFSPSHPL LPLRQKQQKV SQTEEIPDQR HRSNSLTRVD GQPRGAIGAW
PDKKNRPVSQ PTSFALHHAA SCDVDPSSGD SVSLARSISK DSLASNIIHL TPQNQPHPSA
GKSNGKSLLS NVNIEDEDEE LVAIIRTDVS PPSPQMPRTS PQAPGLVASI RSPQRQADTL
ESKPDSFYLE PLMPAVLRPA KEKQITTKED ERGEGRPRTI MAKRPSEGSQ PMVRKKVSGG
HGSRDLNRTF TPIPCSEFAA SIDLAEVGPQ SAEATGEGQP LALGRFDTLP QGQAADGFFL
HVGRAEEDEG RWYVGSQSPS SHDSEPWTIL RQDSDSDVVD VEDTEQDFIG EDHPVVIPRY
AGEEESAKLQ EDMKVKEHED KDDASGRSSP CLSTTSQLSS MSMASGSVKM TSFAERKLQR
LNSCETKSST SSSQKTTPDA SESCPAPLTT WRQKREQSPG RHSKDPASLL ASELVQLHMQ
LEEKRRAIEA QKKKMEALSA RQRLKLGKAA FLHVVKKGKA DGAPQPLRPE HFTKEFTQHN
GEDLDDGTCK TEGFLVKEEQ RDLSDAQDVA FVQLHKPRDP AALHDGEKHR MISTALLEDS
VGEVDVNECD LSIEKLNETI STLQQAILKI SQQQEQLLMK SPTVPTPGTK NNCQDQK
//
