ID A2AHY8_MOUSE Unreviewed; 747 AA.
AC A2AHY8;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE SubName: Full=DDB1 and CUL4 associated factor 8 like {ECO:0000313|Ensembl:ENSMUSP00000109593.3};
DE SubName: Full=Pet2 protein {ECO:0000313|EMBL:AAI38081.1};
GN Name=Dcaf8l {ECO:0000313|Ensembl:ENSMUSP00000109593.3,
GN ECO:0000313|MGI:MGI:101758};
GN Synonyms=Pet2 {ECO:0000313|EMBL:AAI38081.1,
GN ECO:0000313|MGI:MGI:101758};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000109593.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|EMBL:AAI38081.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI38081.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000109593.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109593.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000109593.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109593.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; BC138080; AAI38081.1; -; mRNA.
DR RefSeq; NP_032847.2; NM_008821.2.
DR RefSeq; XP_017173915.1; XM_017318426.1.
DR STRING; 10090.ENSMUSP00000109592; -.
DR PaxDb; 10090-ENSMUSP00000109592; -.
DR ProteomicsDB; 344722; -.
DR DNASU; 18630; -.
DR Ensembl; ENSMUST00000113959.8; ENSMUSP00000109592.2; ENSMUSG00000035395.12.
DR Ensembl; ENSMUST00000113960.3; ENSMUSP00000109593.3; ENSMUSG00000035395.12.
DR GeneID; 18630; -.
DR KEGG; mmu:18630; -.
DR UCSC; uc012hlp.1; mouse.
DR AGR; MGI:101758; -.
DR CTD; 18630; -.
DR MGI; MGI:101758; Dcaf8l.
DR VEuPathDB; HostDB:ENSMUSG00000035395; -.
DR eggNOG; KOG1334; Eukaryota.
DR GeneTree; ENSGT00950000182900; -.
DR HOGENOM; CLU_012381_4_1_1; -.
DR OMA; FISSTEC; -.
DR OrthoDB; 4843437at2759; -.
DR TreeFam; TF326071; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 18630; 6 hits in 76 CRISPR screens.
DR ChiTaRS; Pet2; mouse.
DR Proteomes; UP000000589; Chromosome X.
DR Bgee; ENSMUSG00000035395; Expressed in spermatid and 24 other cell types or tissues.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045151; DCAF8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15574:SF42; DDB1- AND CUL4-ASSOCIATED FACTOR 8-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR15574; WD REPEAT DOMAIN-CONTAINING FAMILY; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:A2AHY8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 349..381
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 35..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..97
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..288
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 83266 MW; 849DE7FC13C0911C CRC64;
MSSHESYTNA AETPENISIL SCLGETSGAL VDTKTISDIK TMDPEVSLTP SSDVTGTEDS
SVLSPQSTDV NSVDSYQGYE GDDDDEEDDE DDKDGDSNLP SLEDSDNFIS CLENSYIPQN
VEKREVVEEQ SLGRRFHPYE LEAGEVVEGQ GGGSLFYPYE LEAGEVVEAQ NVQNLFHRYE
LEEGEVVEAQ VVQSMFPYYE LEAGEVVEAE EVQGFFQRYE LEAREVIGAQ GGQGLSRHYG
LEGGEVVEAT AVRRLIQHHE LEEGEDVDDQ EESSEMHEET SEDSSEQYDI EDDSLIDEWI
ALETSPLPRP RWNVLSALRD RQLGSSGRFV YEACGARLFV QRFSLEHVFE GHSGCVNTVH
FNQHGTLLAS GSDDLKVIVW DWLKKRSVLN FDSGHKNNIL QAKFLPNCND AILAMCGRDG
QVRVAQLSAV AGTHMTKRLV KHGGASHRLG LEPDSPFRFL TSGEDAVVFN IDLRQAHPAS
KLLVIKDGDK KVGLYTVFVN PANVYQFAVG GQDQFMRIYD QRKIDENVNN GVLKKFCPHH
LLSSDYPAHI TSLMYSYDGT EILASYNDED IYIFNSSDSD GAQYAKRYKG HRNNSTVKGV
YFYGPRSEFV MSGSDCGHIF IWEKSSCQIV QFLEADEGGT INCIDSHPYL PVLASSGLDH
EVKIWSPIAE PSKKLAGLKN VIKINKLKRD NFTLRHTSLF NNSMLCFLMS HVTQSNYGRS
WRGIRINAGG GDFSDSSSSS EETNQES
//
