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Database: UniProt
Entry: A2AJ77
LinkDB: A2AJ77
Original site: A2AJ77 
ID   PRD12_MOUSE             Reviewed;         365 AA.
AC   A2AJ77;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   10-APR-2019, entry version 96.
DE   RecName: Full=PR domain zinc finger protein 12;
DE            EC=2.1.1.-;
DE   AltName: Full=PR domain-containing protein 12;
GN   Name=Prdm12; Synonyms=Gm998;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=26005867; DOI=10.1038/ng.3308;
RA   Chen Y.C., Auer-Grumbach M., Matsukawa S., Zitzelsberger M.,
RA   Themistocleous A.C., Strom T.M., Samara C., Moore A.W., Cho L.T.,
RA   Young G.T., Weiss C., Schabhuettl M., Stucka R., Schmid A.B.,
RA   Parman Y., Graul-Neumann L., Heinritz W., Passarge E., Watson R.M.,
RA   Hertz J.M., Moog U., Baumgartner M., Valente E.M., Pereira D.,
RA   Restrepo C.M., Katona I., Dusl M., Stendel C., Wieland T.,
RA   Stafford F., Reimann F., von Au K., Finke C., Willems P.J.,
RA   Nahorski M.S., Shaikh S.S., Carvalho O.P., Nicholas A.K., Karbani G.,
RA   McAleer M.A., Cilio M.R., McHugh J.C., Murphy S.M., Irvine A.D.,
RA   Jensen U.B., Windhager R., Weis J., Bergmann C., Rautenstrauss B.,
RA   Baets J., De Jonghe P., Reilly M.M., Kropatsch R., Kurth I.,
RA   Chrast R., Michiue T., Bennett D.L., Woods C.G., Senderek J.;
RT   "Transcriptional regulator PRDM12 is essential for human pain
RT   perception.";
RL   Nat. Genet. 47:803-808(2015).
CC   -!- FUNCTION: Involved in the positive regulation of histone H3-K9
CC       dimethylation. {ECO:0000269|PubMed:26005867}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H4Q4}.
CC   -!- DEVELOPMENTAL STAGE: Expression starts around 9.0 dpc in the
CC       neural folds, which give rise to neural crest cells. Neural crest
CC       cells develop into various tissues, including the sensory ganglia
CC       that contain nociceptor cell bodies. Prominently expressed in
CC       sensory spinal ganglia (dorsal root ganglia) but not in
CC       sympathetic ganglia during the time when sensory neurons emerge
CC       (10.5 dpc-13.5 dpc), mature and differentiate (14.5 dpc-postnatal
CC       day 14). {ECO:0000269|PubMed:26005867}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; AL732564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS50562.1; -.
DR   RefSeq; NP_001116834.1; NM_001123362.1.
DR   RefSeq; XP_006498224.1; XM_006498161.3.
DR   UniGene; Mm.379512; -.
DR   ProteinModelPortal; A2AJ77; -.
DR   SMR; A2AJ77; -.
DR   STRING; 10090.ENSMUSP00000109098; -.
DR   iPTMnet; A2AJ77; -.
DR   PhosphoSitePlus; A2AJ77; -.
DR   MaxQB; A2AJ77; -.
DR   PaxDb; A2AJ77; -.
DR   PRIDE; A2AJ77; -.
DR   Ensembl; ENSMUST00000113470; ENSMUSP00000109098; ENSMUSG00000079466.
DR   GeneID; 381359; -.
DR   KEGG; mmu:381359; -.
DR   UCSC; uc012bto.1; mouse.
DR   CTD; 59335; -.
DR   MGI; MGI:2685844; Prdm12.
DR   eggNOG; ENOG410IN45; Eukaryota.
DR   eggNOG; ENOG410YUJ3; LUCA.
DR   GeneTree; ENSGT00940000161616; -.
DR   HOGENOM; HOG000231554; -.
DR   HOVERGEN; HBG053666; -.
DR   InParanoid; A2AJ77; -.
DR   OMA; TTGRMRC; -.
DR   OrthoDB; 1318335at2759; -.
DR   TreeFam; TF332260; -.
DR   PRO; PR:A2AJ77; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000079466; Expressed in 36 organ(s), highest expression level in cerebral cortex marginal layer.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:1990226; F:histone methyltransferase binding; ISO:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; ISO:MGI.
DR   GO; GO:0022008; P:neurogenesis; IDA:MGI.
DR   GO; GO:0031175; P:neuron projection development; ISO:MGI.
DR   GO; GO:1900111; P:positive regulation of histone H3-K9 dimethylation; ISO:MGI.
DR   GO; GO:0051574; P:positive regulation of histone H3-K9 methylation; IDA:MGI.
DR   GO; GO:0019233; P:sensory perception of pain; ISO:MGI.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR017126; Znf_PRDM12.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   PIRSF; PIRSF037163; PRDM12; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Methyltransferase;
KW   Nucleus; Reference proteome; Repeat; S-adenosyl-L-methionine;
KW   Transcription; Transcription regulation; Transferase; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    365       PR domain zinc finger protein 12.
FT                                /FTId=PRO_0000416114.
FT   DOMAIN       86    203       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   ZN_FING     243    265       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     271    293       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     299    323       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   COMPBIAS    329    357       Ala-rich.
SQ   SEQUENCE   365 AA;  40303 MW;  C8F9EE188F1B3860 CRC64;
     MMGSVLPAEA LVLKTGLKAP GLALAEVITS DILHSFLYGR WRNVLGEQLL EDKSHHASPK
     TAFTAEVLAQ SFSGEVQKLS SLVLPVEVII AQSSIPGEGL GIFSKTWIKA GTEMGPFTGR
     VIAPEHVDIC KNNNLMWEVF NEDGTVRYFI DASQEDHRSW MTYIKCARNE QEQNLEVVQI
     GTSIFYKAIE MIPPDQELLV WYGNSHNTFL GIPGVPGLEE EQKKNKHEDF HPADSATGTA
     GRMRCVICHR GFNSRSNLRS HMRIHTLDKP FVCRFCNRRF SQSSTLRNHV RLHTGERPYK
     CQVCQSAYSQ LAGLRAHQKS ARHRPPSTAL QAHSPALPAP HAHAPALAAA AAAAAAAHHL
     PAMVL
//
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